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公开(公告)号：US06676902B2
公开(公告)日：2004-01-13
申请号：US10354300
申请日：2003-01-30
申请人： Robert F. Baugh , Julie S. Johnston , Colleen Lutz
发明人： Robert F. Baugh , Julie S. Johnston , Colleen Lutz
IPC分类号： G01N3386
CPC分类号： G01N33/86
摘要： A method and device for testing a sample of fresh whole blood. In particular the present invention provides a method and device for testing a sample of fresh whole blood to determine whether a patient would benefit from the administration of a blood factor (such as AT III.)
摘要翻译： 用于测试新鲜全血样品的方法和装置。 特别地，本发明提供了一种用于测试新鲜全血样品的方法和装置，以确定患者是否可以从血液因子的给药中获益（例如AT III）
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公开(公告)号：US07838039B2
公开(公告)日：2010-11-23
申请号：US11044984
申请日：2005-01-27
IPC分类号： A61K35/16
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： Provided are methods of applying biological compositions, that is, autologous bioadhesive sealant compositions containing one or more biological agents, to an individual, wherein all the blood components used in preparing the composition are derived from the patient who is to receive the biological composition. In one embodiment, the method comprises obtaining a whole blood sample from an individual; forming an inactive platelet rich plasma from the whole blood sample; mixing a biological agent into the inactive platelet rich plasma; obtaining thrombin from the whole blood sample; mixing the thrombin into the inactive platelet rich plasma to form a biological composition; and applying the biological composition to the individual.
摘要翻译： 提供了将生物组合物，即含有一种或多种生物制剂的自体生物粘附密封剂组合物施用于个体的方法，其中用于制备组合物的所有血液成分来源于接受生物组合物的患者。 在一个实施方案中，该方法包括从个体获得全血样品; 从全血样品中形成无活性血小板富集血浆; 将生物试剂混合到无活性富血小板血浆中; 从全血样品中获得凝血酶; 将凝血酶混合到无活性血小板富集血浆中以形成生物组合物; 并将生物组合物应用于个体。
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公开(公告)号：US06830762B2
公开(公告)日：2004-12-14
申请号：US10173839
申请日：2002-06-18
IPC分类号： A61K3516
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. In one embodiment, the platelet rich plasma is divided into two portions. In phase one, a compound that reverses the effect of the anticoagulant is added to the first portion and a clot is allowed to form. The clot is then triturated, and the resulting serum containing autologous thrombin is collected. In phase two, the serum obtained from phase one is mixed with the second portion of the platelet rich plasma to form the bioadhesive sealant of the present invention.
摘要翻译： 本发明涉及通过两相方法制备的自体生物粘附密封剂组合物或纤维蛋白胶，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 通过离心一定数量的抗凝血全血形成血小板富血浆和不血小板血浆。 在一个实施方案中，富血小板血浆被分成两部分。 在第一阶段中，将反转抗凝血剂作用的化合物加入第一部分，并形成凝块。 然后将凝块研磨，收集所得到的含有自体凝血酶的血清。 在第二阶段中，将从第一阶段获得的血清与富含血小板的血浆的第二部分混合以形成本发明的生物粘附密封剂。
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公开(公告)号：US08303993B2
公开(公告)日：2012-11-06
申请号：US11159482
申请日：2005-06-23
IPC分类号： A61K35/16
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： The present relates to an autologous bioadhesive sealant composition, or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. In one embodiment the platelet rich plasma is divided into two portions. In phase one, a compound that reverses the effect of the anticoagulant is added to the first portion and a clot is allowed to form. The clot is then triturated, and the resulting, serum containing autologous thrombin is collected. In phase two, the serum obtained from phase one is mixed with the second portion of the-platelet rich plasma to form the bioadhesive sealant of the invention.
摘要翻译： 本发明涉及一种通过两相方法制备的自体生物粘附密封剂组合物或纤维蛋白胶，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 通过离心一定数量的抗凝血全血形成血小板富血浆和不血小板血浆。 在一个实施方案中，富血小板血浆被分成两部分。 在第一阶段中，将反转抗凝血剂作用的化合物加入第一部分，并形成凝块。 然后将凝块研磨，并收集所得的含有自体凝血酶的血清。 在第二阶段，将从第一阶段获得的血清与富含血小板的血浆的第二部分混合以形成本发明的生物粘附密封剂。
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公开(公告)号：US07811607B2
公开(公告)日：2010-10-12
申请号：US11004023
申请日：2004-12-03
IPC分类号： A61K35/16
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. A platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. In one embodiment, the platelet rich plasma is divided into two portions. In phase one, a compound that reverses the effect of the anticoagulant is added to the first portion and a clot is allowed to form. The clot is then triturated, and the resulting serum containing autologous thrombin is collected. In phase two, the serum obtained from phase one is mixed with the second portion of the platelet rich plasma to form the bioadhesive sealant of the present invention.
摘要翻译： 本发明涉及通过两相方法制备的自体生物粘附密封剂组合物或纤维蛋白胶，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 通过离心一定数量的抗凝血全血形成血小板富血浆和不血小板血浆。 在一个实施方案中，富血小板血浆被分成两部分。 在第一阶段中，将反转抗凝血剂作用的化合物加入第一部分，并形成凝块。 然后将凝块研磨，收集所得到的含有自体凝血酶的血清。 在第二阶段中，将从第一阶段获得的血清与富含血小板的血浆的第二部分混合以形成本发明的生物粘附密封剂。
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公开(公告)号：US06596180B2
公开(公告)日：2003-07-22
申请号：US09833234
申请日：2001-04-09
IPC分类号： B01D2126
CPC分类号： A61L26/0057 , A61L24/0005 , A61L24/106 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , Y10T436/25375
摘要： A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel.
摘要翻译： 一种用于形成自体血小板凝胶的离心机系统，其中所述凝胶的所有血液成分来源于要施用凝胶的患者。 首先通过离心一定数量的抗凝血全血形成血小板富血浆和血小板不良血浆，这是先前从患者中抽出的。 然后将富含血小板的血浆或血小板不良等离子体自动从离心机中抽出并在分配器中成比例分成不同的室。 在形成凝块并获得凝血酶的情况下，第一部分被激活。 然后将凝血酶与第二部分混合以获得血小板凝胶。
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公开(公告)号：US06444228B1
公开(公告)日：2002-09-03
申请号：US09063338
申请日：1998-04-20
IPC分类号： A61K3516
CPC分类号： A61L24/106
摘要： In general, the present invention relates to a two-phase method for forming an autologous bioadhesive sealant composition or fibrin glue wherein all of the blood components for the bioadhesive sealant are derived from a patient to whom the bioadhesive sealant will be applied. First, a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma and platelet poor plasma are then divided into two portions. To the first portion, which is used in phase-one, a compound that reverses the effect of the anticoagulant is added, and a clot is allowed to form. The clot is then triturated and the resulting serum, containing autologous thrombin, is collected. The serum obtained from phase-one is then mixed with the second portion of the platelet rich plasma or platelet poor plasma, used in phase-two, to form the bioadhesive sealant of the present invention.
摘要翻译： 通常，本发明涉及用于形成自体生物粘附密封剂组合物或纤维蛋白胶的两相方法，其中用于生物粘附密封剂的所有血液成分衍生自将要施用生物粘附密封剂的患者。 首先，通过离心从患者预先抽取的一定数量的抗凝血形成血小板富血浆和血小板不足等离子体。 然后将富血小板血浆和血小板不良血浆分成两部分。 在第一阶段使用的第一部分，加入逆转抗凝血剂作用的化合物，并允许形成凝块。 然后研磨凝块，收集含有自体凝血酶的血清。 然后从第一阶段获得的血清与第二阶段使用的富血小板血浆或血小板贫血血浆的第二部分混合，形成本发明的生物粘附密封剂。
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