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公开(公告)号：US06773923B2
公开(公告)日：2004-08-10
申请号：US09809062
申请日：2001-03-16
申请人： Jürgen Patzke
发明人： Jürgen Patzke
IPC分类号： G01N3386
摘要： The invention relates to a method for measuring the aggregation or agglutination of platelets, where a reaction mixture is mixed in a first reaction phase, and is mixed less vigorously or not at all in a second reaction phase following the first, and the measurement is preferably carried out in the second reaction phase.
摘要翻译： 本发明涉及一种用于测量血小板聚集或凝集的方法，其中反应混合物在第一反应相中混合，并且在第一反应阶段之后的第二反应阶段中不太有力或不完全混合，并且测量优选 在第二反应阶段进行。
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公开(公告)号：US06746872B2
公开(公告)日：2004-06-08
申请号：US10055788
申请日：2002-01-16
申请人： Xiang Yang Zheng , Brian Earp , Herbert Chow , Christa Hartmann
发明人： Xiang Yang Zheng , Brian Earp , Herbert Chow , Christa Hartmann
IPC分类号： G01N3386
CPC分类号： G01N33/86 , Y10T436/10 , Y10T436/106664
摘要： Compositions, methods, devices and kits for use in the calibration of coagulation tests. The control compositions include particles capable of aggregating in plasma and calcium ions which, when mixed with plasma, simulate the behavior of whole blood in a coagulation test. The methods include providing calcium ions and particles capable of aggregating in plasma, combining the particles and calcium ions with plasma to form a control composition, and applying the control composition to a coagulation test. The devices include a container having at least two compartments, with one compartment including particles that promote or induce aggregation of a protein or proteins in plasma, and the other compartment includes a solution of calcium ions. The kits include a control composition including a container of calcium ions, a container of particles capable of inducing aggregation of proteins in plasma, and one or more coagulation test devices.
摘要翻译： 用于校准凝血试验的组合物，方法，装置和试剂盒。 对照组合物包括能够在血浆和钙离子中聚集的颗粒，当与血浆混合时，模拟凝血试验中全血的行为。 所述方法包括提供能够在血浆中聚集的钙离子和颗粒，将颗粒和钙离子与血浆组合以形成对照组合物，并将对照组合物施用于凝血试验。 这些装置包括具有至少两个隔室的容器，其中一个隔室包括促进或诱导血浆中蛋白质或蛋白质聚集的颗粒，另一隔室包括钙离子溶液。 试剂盒包括包含钙离子容器的控制组合物，能够诱导血浆中的蛋白质聚集的颗粒的容器和一个或多个凝固测试装置。
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公开(公告)号：US06617166B2
公开(公告)日：2003-09-09
申请号：US09907280
申请日：2001-07-17
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N2333/78
摘要： Disclosed is The method of in vitro testing of the state of the blood coagulation system. The Accelerated Whole Blood Clotting Time (A. W. B. C. T.) reflects the degree of over or under activity of the coagulation system of the blood.
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公开(公告)号：US06613573B1
公开(公告)日：2003-09-02
申请号：US09591371
申请日：2000-06-09
申请人： Eli Cohen
发明人： Eli Cohen
IPC分类号： G01N3386
CPC分类号： G01N11/162 , G01N11/167 , G01N33/86
摘要： A blood coagulation analyzer, such as the Thrombelastograph® (TEG®) blood coagulation analyzer is utilized to measure continuously in real time, the clotting process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood coagulation parameters. The measured blood coagulation parameters permit confirmation of the attainment of therapeutic level of GPIIb/IIIa receptor blockade; individualized dosing assessment to evaluate attainment of adequate GPIIb/IIIa receptor blockade; individualized dosing assessment required to reach adequate GPIIb/IIIa receptor blockade; illustration of the rate of diminishment of platelet inhibition or inhibition recovery after treatment with platelet-inhibition drugs; evaluation of the interaction effect of a combination of thrombolytic or any other agents or conditions effecting hemostasis and platelet-inhibiting agents on patient hemostasis.
摘要翻译： 使用血液凝固分析仪，例如凝血分析仪（TEG），用于实时连续测量凝血过程，从初始纤维蛋白形成，通过血小板 - 纤维蛋白相互作用和裂解产生血液凝固 参数。 测量的血液凝固参数允许确认达到GPIIb / IIIa受体阻断的治疗水平; 个体化给药评估以评估达到足够的GPIIb / IIIa受体阻断; 个体化的给药评估需要达到足够的GPIIb / IIIa受体阻断; 说明用血小板抑制药物治疗后血小板抑制或抑制恢复减少的速率; 评估血栓溶解组合或任何其他试剂或影响止血和血小板抑制剂的患者与患者止血的相互作用效应。
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公开(公告)号：US06232127B1
公开(公告)日：2001-05-15
申请号：US09330545
申请日：1999-06-11
IPC分类号： G01N3386
CPC分类号： G01N33/4905 , G01N33/86 , G01N2400/40 , G01N2405/04 , Y10T436/10 , Y10T436/107497 , Y10T436/108331
摘要： An improved apparatus and method for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells includes a platelet function restoration agent, an anticoagulant agent, and a clotting reagent. At least one of the cells also includes a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method includes the steps of combining a platelet function restoration agent, an anticoagulant agent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by adding a clotting reagent to the test mixture at the start of the activated clotting time test, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于评估血液样品的血小板功能的改进的装置和方法。 该装置包括多个测试单元。 每个细胞包括血小板功能恢复剂，抗凝血剂和凝血试剂。 至少一个细胞还包括血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括将血小板功能恢复剂，抗凝血剂，血小板活化剂和待测试血液样品组合以形成测试混合物的步骤。 在激活的凝血时间试验开始时，通过向试验混合物中加入凝血试剂来激活样品的血小板，并且在检测到试验混合物的性质的预定变化后终止活化的凝固时间试验。 根据经过的时间计算血液样品的活化凝血时间。
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公开(公告)号：US06761856B2
公开(公告)日：2004-07-13
申请号：US10410003
申请日：2003-04-09
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets, the apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.
摘要翻译： 提供了一种用于对含有血小板的样品进行活化的凝血时间测试的装置，所述装置包括多个测试细胞，所述细胞适于接收所述样品的等分部分，其中每个所述细胞包含抗凝血剂和 血小板灭活剂，并且其中所述细胞中的至少一个还包含凝血活化剂，其中确定每个所述等分部分的凝血时间，并且其中确定包含凝血激活剂的每个所述等分部分的相对凝血时间 与所述至少一种不含凝血活化剂的细胞的参考凝血时间相比，其中所述细胞中的所述相对凝血时间决定所述凝血活化剂的凝血活化。
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7.发明授权Method for detecting, treating, and monitoring conditions associated with activation of the coagulation response 失效用于检测，治疗和监测与凝血反应活化相关的病症的方法公开(公告)号：US06692969B1
公开(公告)日：2004-02-17
申请号：US09637808
申请日：2000-08-11
IPC分类号： G01N3386
CPC分类号： G01N33/6893 , C12Q1/6883 , G01N33/86 , G01N2800/10 , G01N2800/306 , Y02A50/57
摘要： This invention relates to a method for using a novel combination of assays to detect minimal activation of the coagulation response for determining whether a patient whose initial clinical evaluation indicates chronic fatigue syndrome, fibromyalgia, and related conditions can be treated using anticoagulant therapies. If activation of the coagulation response is detected, the present invention further includes treatment of CFS, FM or related condition using anticoagulant therapies.
摘要翻译： 本发明涉及一种使用测定新组合来检测凝血反应的最小活化的方法，用于确定是否可以使用抗凝血疗法治疗其初始临床评估表明慢性疲劳综合征，纤维肌痛和相关病症的患者。 如果检测到凝血反应的活化，本发明还包括使用抗凝血剂治疗CFS，FM或相关病症的治疗。
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公开(公告)号：US06689615B1
公开(公告)日：2004-02-10
申请号：US09679130
申请日：2000-10-04
申请人： James Murto , Michael Salvati
发明人： James Murto , Michael Salvati
IPC分类号： G01N3386
CPC分类号： B03C1/01 , B03C1/286 , G01N33/491 , G01N33/5002 , Y10S436/806 , Y10S436/815 , Y10S436/817 , Y10S436/818 , Y10S436/824 , Y10S436/827 , Y10T436/106664 , Y10T436/25375 , Y10T436/255
摘要： Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically attractable particles bind the cellular components in a whole blood sample. Application of a magnetic field gradient to a container with the blood sample and the magnetically attractable particles draws the particles to the surface of the container near the source of the magnetic field gradient. The plasma can be removed and stored or used for monitoring or detecting analytes in the plasma.
摘要翻译： 描述了用于从全血样品中分离血浆的方法，并且包括使用与凝集剂相关的磁吸引颗粒。 磁吸引颗粒结合全血样品中的细胞组分。 将磁场梯度施加到具有血液样品和可磁吸引颗粒的容器中将颗粒吸引到容器的靠近磁场梯度源的表面。 等离子体可以被去除并存储或用于监测或检测等离子体中的分析物。
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9.发明授权公开(公告)号：US06596543B2
公开(公告)日：2003-07-22
申请号：US09815398
申请日：2001-03-22
IPC分类号： G01N3386
CPC分类号： A61K9/127
摘要： The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native thromboplastin or purified or recombinant tissue factor and phospholipids from a natural or synthetic source. The present invention relates to methods to make a diagnostic reagent that includes a membrane-bound protein incorporated into a liposome and having additional empty liposomes (liposomes without membrane-bound protein incorporated therein) added to the solution.
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公开(公告)号：US06531321B1
公开(公告)日：2003-03-11
申请号：US09662960
申请日：2000-09-15
申请人： Wayne L. Ryan , Bradford A. Hunsley
发明人： Wayne L. Ryan , Bradford A. Hunsley
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/5094 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A control and system for blood testing, including a control having stabilized blood cells that have been introduced into a suspension including an aggregating agent and preferably a surfactant. The control and system is used advantageously for indirect acute protein plasma measurement, including erythrocyte sedimentation rate testing.
摘要翻译： 一种用于血液检测的对照和系统，包括具有稳定的血细胞的对照物，该对照物已被引入包含聚集剂和优选表面活性剂的悬浮液中。 控制和系统有利地用于间接急性蛋白质血浆测量，包括红细胞沉降速率测试。
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