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    Generation of profiled light packets
    1.
    发明申请
    Generation of profiled light packets 审中-公开
    生成异型光数据包

    公开(公告)号：US20100118900A1

    公开(公告)日：2010-05-13

    申请号：US12291919

    申请日：2008-11-13

    申请人： Robert G. Waarts ,  Gregory J.R. Spooner

    发明人： Robert G. Waarts ,  Gregory J.R. Spooner

    IPC分类号： H01S3/10

    CPC分类号： H01S3/0057 ,  H01S3/06754 ,  H01S3/1305 ,  H01S3/2325 ,  H01S5/50 ,  H01S2301/02

    摘要： Exemplary systems and methods are directed toward the creation of packets of light. A packet contains one or more pulses of light. In some embodiments, the packet may contain two, ten, 100, 1000, 1E6, or more pulses of light. The packet may be characterized by many of the same properties that are used to describe pulses, such as packet energy, packet width, packet power, packet period (for a periodic series of packets), and peak power of the packet. Packets may also be characterized by other properties describing their shapes. These properties may be described or defined by mathematical functions when the packets have complicated shapes.

    摘要翻译： 示例性的系统和方法针对光分组的创建。 分组包含一个或多个光脉冲。 在一些实施例中，分组可以包含两个，10,100,1000,1E6或更多个光脉冲。 分组的特征可以在于用于描述诸如分组能量，分组宽度，分组功率，分组周期（对于周期性分组）的脉冲的许多相同的属性以及分组的峰值功率。 数据包也可以通过描述其形状的其他属性来表征。 当数据包具有复杂的形状时，可以通过数学函数描述或定义这些属性。

    VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR
    2.
    发明申请
    VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR 失效
    药物残留破裂的可视化指标

    公开(公告)号：US20110098640A1

    公开(公告)日：2011-04-28

    申请号：US12910572

    申请日：2010-10-22

    申请人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

    发明人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

    IPC分类号： A61M31/00 ,  A61F9/00 ,  A61K31/573 ,  A61P27/02 ,  A61P9/10 ,  A61P27/06 ,  A61P35/00 ,  A61P27/12

    CPC分类号： A61F9/0017 ,  A61F2002/30714 ,  A61F2250/0068 ,  A61F2250/0089 ,  A61F2250/0097 ,  A61K9/0009 ,  A61K9/0051

    摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

    摘要翻译： 本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。 特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。 所述方法包括将药物递送装置植入受试者的解剖结构内。 药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。 此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。 该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。 通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

    LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE
    4.
    发明申请
    LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 有权
    低渗透性，激光激活药物递送装置

    公开(公告)号：US20120035528A1

    公开(公告)日：2012-02-09

    申请号：US13023370

    申请日：2011-02-08

    申请人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    发明人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    IPC分类号： A61M37/00 ,  B65B1/04

    CPC分类号： A61F9/0017 ,  A61F9/008 ,  A61K9/0009 ,  A61K9/0051

    摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

    摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。

    ULTRASOUND SYSTEM AND METHOD FOR HAIR REMOVAL
    5.
    发明申请
    ULTRASOUND SYSTEM AND METHOD FOR HAIR REMOVAL 审中-公开
    超声波清除系统和方法

    公开(公告)号：US20080183110A1

    公开(公告)日：2008-07-31

    申请号：US11851351

    申请日：2007-09-06

    申请人： Scott A. Davenport ,  Gregory J.R. Spooner

    发明人： Scott A. Davenport ,  Gregory J.R. Spooner

    IPC分类号： A61N7/02

    CPC分类号： A61N7/02 ,  A61B2017/00752 ,  A61B2018/00005 ,  A61N2007/0056 ,  A61N2007/0078 ,  A61N2007/0082

    摘要： In a method for removing hair using ultrasound, one or more pulses of ultrasound energy are applied to the tissue at a frequency (e.g. 5-15 MHz) selected to deliver the energy a tissue depths corresponding to those at which hair follicles are located. Pulse widths are selected to correspond to thermal relaxation times for hair. The skin may be optionally cooled before, during, and/or after ultrasound exposure.

    摘要翻译： 在使用超声波去除头发的方法中，以选择的频率（例如5-15MHz）将一个或多个超声能量脉冲施加到组织，以将能量传递给与毛囊所在的组织深度相对应的组织深度。 选择脉冲宽度以对应于头发的热松弛时间。 可以在超声暴露之前，期间和/或之后任选地冷却皮肤。