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    LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE
    1.
    发明申请
    LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 有权
    低渗透性，激光激活药物递送装置

    公开(公告)号：US20120035528A1

    公开(公告)日：2012-02-09

    申请号：US13023370

    申请日：2011-02-08

    申请人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    发明人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    IPC分类号： A61M37/00 ,  B65B1/04

    CPC分类号： A61F9/0017 ,  A61F9/008 ,  A61K9/0009 ,  A61K9/0051

    摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

    摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。

    VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR
    2.
    发明申请
    VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR 失效
    药物残留破裂的可视化指标

    公开(公告)号：US20110098640A1

    公开(公告)日：2011-04-28

    申请号：US12910572

    申请日：2010-10-22

    申请人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

    发明人： Kenneth N. HORNE ,  Gregory J.R. Spooner ,  John A. Scholl ,  John T. Santini, JR.

    IPC分类号： A61M31/00 ,  A61F9/00 ,  A61K31/573 ,  A61P27/02 ,  A61P9/10 ,  A61P27/06 ,  A61P35/00 ,  A61P27/12

    CPC分类号： A61F9/0017 ,  A61F2002/30714 ,  A61F2250/0068 ,  A61F2250/0089 ,  A61F2250/0097 ,  A61K9/0009 ,  A61K9/0051

    摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

    摘要翻译： 本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。 特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。 所述方法包括将药物递送装置植入受试者的解剖结构内。 药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。 此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。 该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。 通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

    DEVICE FOR CONTROLLING EXPOSURE OF RESERVOIR CONTENTS TO SURROUNDINGS
    4.
    发明申请
    DEVICE FOR CONTROLLING EXPOSURE OF RESERVOIR CONTENTS TO SURROUNDINGS 有权
    控制环境中储层暴露的装置

    公开(公告)号：US20090112188A1

    公开(公告)日：2009-04-30

    申请号：US12348609

    申请日：2009-01-05

    申请人： John T. Santini, JR. ,  Michael J. Cima ,  Scott Albert Uhland

    发明人： John T. Santini, JR. ,  Michael J. Cima ,  Scott Albert Uhland

    IPC分类号： A61K9/22

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

    摘要翻译： 提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外部环境连通 储存器盖以使所述储存器盖发生相变和破裂。

    MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS
    5.
    发明申请
    MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 审中-公开
    具有保护性内部墙壁的多储存医疗设备

    公开(公告)号：US20090024113A1

    公开(公告)日：2009-01-22

    申请号：US12193523

    申请日：2008-08-18

    申请人： John M. Maloney ,  Zouhair Sbiaa ,  John T. Santini, JR. ,  Norman F. Sheppard, JR. ,  Scott A. Uhland

    发明人： John M. Maloney ,  Zouhair Sbiaa ,  John T. Santini, JR. ,  Norman F. Sheppard, JR. ,  Scott A. Uhland

    IPC分类号： A61K9/22

    CPC分类号： B01L3/50853 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon.

    摘要翻译： 提供可植入医疗装置用于控制输送或暴露储存器内容物。 该装置可以包括基板; 在所述基板中的多个分立储存器，其中所述储存器具有内壁和所述基板中的至少一个开口; 蓄水池内容物; 储存器盖封闭每个储存器的至少一个开口以密封每个储存器中的储存器内容物; 以及用于选择性地分解储存器盖以释放或暴露储存器内容物在体内的控制电路，其中储存器的内壁包括在体内保护基板的材料。 例如，为了增强衬底在体内蚀刻的电阻，储存器的内侧壁可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅或硅化铂），或者侧壁可以 包括掺杂硅。

    IMPLANTABLE DEVICE FOR CONTROLLED, EXTENDED DELIVERY OF PARATHYROID HORMONE
    6.
    发明申请
    IMPLANTABLE DEVICE FOR CONTROLLED, EXTENDED DELIVERY OF PARATHYROID HORMONE 有权
    用于控制，延伸的PARATHYROID HORMONE的可植入装置

    公开(公告)号：US20090163895A1

    公开(公告)日：2009-06-25

    申请号：US12358850

    申请日：2009-01-23

    申请人： Dennis Ausiello ,  John T. Santini, JR. ,  Stephen J. Herman ,  James H. Prescott ,  Scott A. Uhland ,  John M. Maloney ,  Benjamin F. Polito

    发明人： Dennis Ausiello ,  John T. Santini, JR. ,  Stephen J. Herman ,  James H. Prescott ,  Scott A. Uhland ,  John M. Maloney ,  Benjamin F. Polito

    IPC分类号： A61M37/00

    CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K9/0036 ,  A61K9/0097 ,  A61K38/29 ,  A61K2300/00

    摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

    摘要翻译： 提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。 所述方法包括将医疗装置植入患者体内，所述医疗装置包括衬底，衬底中的多个储存器，每个储存器中包含的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。 间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。 该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。 该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

    ELECTROCHEMICAL BIOSENSORS AND ARRAYS
    8.
    发明申请
    ELECTROCHEMICAL BIOSENSORS AND ARRAYS 有权
    电化学传感器和阵列

    公开(公告)号：US20080302659A1

    公开(公告)日：2008-12-11

    申请号：US12134966

    申请日：2008-06-06

    申请人： Norman F. Sheppard, JR. ,  John T. Santini, JR.

    发明人： Norman F. Sheppard, JR. ,  John T. Santini, JR.

    IPC分类号： G01N33/487 ,  A61M25/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/004 ,  G01N27/3272

    摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.

    摘要翻译： 以各种电流，电位和电导率的传感器装置配置提供电化学传感器装置。 电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储存器内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

    Solid drug formulation and device for storage and controlled delivery thereof
    10.
    发明申请
    Solid drug formulation and device for storage and controlled delivery thereof 审中-公开
    固体药物制剂及其储存和控制递送装置

    公开(公告)号：US20100119604A1

    公开(公告)日：2010-05-13

    申请号：US12612828

    申请日：2009-11-05

    申请人： James H. Prescott ,  Scott A. Uhland ,  Mark A. Staples ,  John T. Santini, JR.

    发明人： James H. Prescott ,  Scott A. Uhland ,  Mark A. Staples ,  John T. Santini, JR.

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  A61K38/09

    摘要： Devices and methods are provided for the storage and controlled release of a solid form of a drug. The device comprises a body portion; one or more reservoirs located in and defined by the body portion; a solid matrix which comprises a drug and which is contained in each of the one or more reservoirs; and one or more excipient materials dispersed throughout pores or interstices within the solid matrix and substantially filling any space not otherwise occupied by the solid matrix within each of the one or more reservoirs, wherein the excipient material enhances stability of the drug while stored in the one or more reservoirs or enhances release of the drug from each reservoir. In an alternative embodiment, the device provides for the storage and controlled exposure of a chemical sensor material.

    摘要翻译： 提供了用于药物的固体形式的储存和控制释放的装置和方法。 该装置包括主体部分; 一个或多个储存器，位于主体部分中并由主体部分限定; 固体基质，其包含药物并且包含在所述一个或多个储存器中的每一个中; 以及分散在固体基质内的整个孔或间隙中的一种或多种赋形剂材料，并且基本上填充一个或多个储存器内的每一个中不另外占据固体基质的任何空间，其中赋形剂材料增强药物的稳定性，同时储存在一个 或更多的储存器或增强药物从每个储存器的释放。 在替代实施例中，该装置提供化学传感器材料的存储和受控曝光。