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    Methods and kits for delivering cortical electrode leads into patient's head
    1.
    发明申请
    Methods and kits for delivering cortical electrode leads into patient's head 有权
    将皮质电极导入患者头部的方法和试剂盒

    公开(公告)号：US20060129203A1

    公开(公告)日：2006-06-15

    申请号：US11010232

    申请日：2004-12-10

    申请人： Robert Garabedian ,  Michael Wallace ,  Gary Heit

    发明人： Robert Garabedian ,  Michael Wallace ,  Gary Heit

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0531 ,  A61N1/0539 ,  A61N1/36082

    摘要： Methods and kits for delivering an electrode lead into the head of a patient are provided. A burr hole is formed within the cranium of the patient, and an electrode lead is threaded through the burr hole. The electrode lead is then placed in a pre-shaped two-dimensional geometry between the cranium and cortical brain tissue of the patient. An access anchor may be mounted into the burr hole to facilitate introduction and removal of the electrode lead and other devices. In some circumstances, it may be desirable to separate the dura mater overlying the cortical brain tissue from the cortical brain tissue to create a pocket in which the electrode lead may be manipulated. In this case, a tissue layer dissection device can be introduced through the burr hole, operated to separate the dura mater from the cranium, and then removed from the burr hole. In one embodiment, the dissection device comprises a balloon that can be inflated to separate the dura mater and cranium, and then deflated prior to removing the dissection device from the burr hole.

    摘要翻译： 提供了用于将电极引线输送到患者头部的方法和套件。 在患者的颅骨内形成有钻孔，电极引线穿过毛刺孔。 然后将电极引线置于患者的颅骨和皮质脑组织之间的预先形状的二维几何形状中。 可以将入口锚固件安装到钻孔中以便于引入和移除电极引线和其它装置。 在某些情况下，可能需要将覆盖皮质脑组织的硬膜与皮层脑组织分离，以产生可以操纵电极引线的口袋。 在这种情况下，可以通过毛刺孔引入组织层解剖装置，操作以将硬脑膜与头颅分开，然后从毛刺孔中取出。 在一个实施例中，解剖装置包括可以充气以分离硬脑膜和颅骨的气囊，然后在从毛刺孔移除解剖装置之前放气。

    Method for stimulating neural tissue in response to a sensed physiological event
    2.
    发明申请
    Method for stimulating neural tissue in response to a sensed physiological event 审中-公开
    响应于感测到的生理事件刺激神经组织的方法

    公开(公告)号：US20060058854A1

    公开(公告)日：2006-03-16

    申请号：US10941382

    申请日：2004-09-14

    申请人： Robert Abrams ,  Michael Wallace ,  Robert Garabedian

    发明人： Robert Abrams ,  Michael Wallace ,  Robert Garabedian

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

    摘要： A method of treating a disorder of a patient, such as a neurological disorder, is provided. The method comprises intravascularly delivering at least one of a stimulation lead and a sensing lead within the head of the patient. For example, one or both of the leads can be delivered into the patient's head via the circulatory system (e.g., vein or artery) or the ventricular system (e.g., through the intrathecal space of the spine). The method further comprises sensing a physiological event associated with the disorder (e.g., physiological electrical activity, a blood parameter, or intracranial pressure) using the sensing lead, and stimulating neural tissue with the stimulation lead in response to the sensed physiological event.

    摘要翻译： 提供了治疗患者疾病如神经障碍的方法。 该方法包括在患者头部内血管内输送刺激引线和感测引线中的至少一个。 例如，一个或两个引线可以通过循环系统（例如静脉或动脉）或心室系统（例如，通过脊柱的鞘内空间）递送到患者的头部。 该方法还包括使用感测引线感测与病症相关的生理事件（例如，生理电活动，血液参数或颅内压），以及响应感测的生理事件刺激刺激引线的神经组织。

    Collapsible/Expandable Tubular Electrode Leads
    4.
    发明申请
    Collapsible/Expandable Tubular Electrode Leads 有权
    可折叠/可扩展管状电极引线

    公开(公告)号：US20060259110A1

    公开(公告)日：2006-11-16

    申请号：US11459618

    申请日：2006-07-24

    申请人： Michael Wallace ,  Robert Garabedian

    发明人： Michael Wallace ,  Robert Garabedian

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0553

    摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.

    摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

    Collapsible/expandable tubular electrode leads
    5.
    发明申请
    Collapsible/expandable tubular electrode leads 审中-公开
    可折叠/可扩展管状电极引线

    公开(公告)号：US20050203600A1

    公开(公告)日：2005-09-15

    申请号：US10799295

    申请日：2004-03-12

    申请人： Michael Wallace ,  Robert Garabedian

    发明人： Michael Wallace ,  Robert Garabedian

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0553

    摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. In the preferred embodiment, the tubular membrane has a non-circular cross-sectional shape. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.

    摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。 在优选实施例中，管状膜具有非圆形横截面形状。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

    Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads
    6.
    发明申请
    Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 有权
    通过血管内和非血管输送导联组合刺激/感觉脑的方法

    公开(公告)号：US20050187589A1

    公开(公告)日：2005-08-25

    申请号：US10783679

    申请日：2004-02-20

    申请人： Michael Wallace ,  Robert Garabedian

    发明人： Michael Wallace ,  Robert Garabedian

    IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/36

    CPC分类号： A61N1/36025 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082

    摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a first electrical lead within the head of the patient, and non-vascularly delivering a second electrical lead within the head the patient. The vascular and intravascular leads are placed adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue). Optionally, the method comprises implanting a source of stimulation and/or recorder within the patient's body, and then electrically coupling the proximal ends of the electrical leads to the implanted device. Using the electrical leads, the brain tissue can then be stimulated and/or recorded in order to treat the neurological disorder.

    摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内传递患者头部内的第一电引线，并且在患者的头部内非血管输送第二电引线。 血管和血管内引线被放置在脑组织（例如皮质脑组织或深部脑组织）附近。 可选地，该方法包括在患者体内植入刺激源和/或记录器源，然后将电引线的近端电连接到植入装置。 使用电引线，然后可以刺激和/或记录脑组织以治疗神经障碍。

    Method of intravascularly delivering stimulation leads into direct contact with tissue
    7.
    发明申请
    Method of intravascularly delivering stimulation leads into direct contact with tissue 失效
    血管内传递刺激的方法导致与组织的直接接触

    公开(公告)号：US20050137647A1

    公开(公告)日：2005-06-23

    申请号：US10744853

    申请日：2003-12-22

    申请人： Michael Wallace ,  Kamal Ramzipoor ,  Robert Garabedian ,  Robert Abrams

    发明人： Michael Wallace ,  Kamal Ramzipoor ,  Robert Garabedian ,  Robert Abrams

    IPC分类号： A61N1/05 ,  A61N1/18

    CPC分类号： A61N1/0529 ,  A61N1/0531 ,  A61N1/0534

    摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.

    摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。