公开(公告)号：US20060088527A1

公开(公告)日：2006-04-27

申请号：US11301554

申请日：2005-12-13

申请人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

发明人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/06 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US20100069877A1

公开(公告)日：2010-03-18

申请号：US12556668

申请日：2009-09-10

申请人： Gregory A. Smith ,  Dale Kalamasz ,  Tyler D.J. Westcott ,  Robert P. Kinsey ,  Darrick Carter ,  Paul Sleath

发明人： Gregory A. Smith ,  Dale Kalamasz ,  Tyler D.J. Westcott ,  Robert P. Kinsey ,  Darrick Carter ,  Paul Sleath

IPC分类号： A61M5/00 ,  A61K31/167 ,  A61P23/02

CPC分类号： A61K31/137 ,  A61J3/00 ,  A61K9/08 ,  A61K31/00 ,  A61K31/167 ,  A61K47/38 ,  A61N1/0448 ,  A61K2300/00

摘要： Systems and methods are provided for dispensing compositions comprising sols, sol-forming compounds, or highly viscous compositions into porous substrates. In some embodiments, the porous substrates are elements of transdermal delivery devices. In some embodiments, the highly viscous compositions comprise alkylcellulose ethers, or derivatives thereof, in particular, hydroxypropyl cellulose. Such may be useful in continuous web-based manufacturing processes.

摘要翻译： 提供了用于将包含溶胶，溶胶形成化合物或高粘度组合物的组合物分配到多孔基材中的系统和方法。 在一些实施方案中，多孔底物是透皮递送装置的元件。 在一些实施方案中，高粘度组合物包含烷基纤维素醚或其衍生物，特别是羟丙基纤维素。 这在连续的基于web的制造过程中可能是有用的。

公开(公告)号：US20060188474A1

公开(公告)日：2006-08-24

申请号：US11213530

申请日：2005-08-25

申请人： Paul Sleath ,  Roy Black ,  Shirley Kronheim

发明人： Paul Sleath ,  Roy Black ,  Shirley Kronheim

IPC分类号： A61K38/20 ,  C07K14/545 ,  C07H21/04 ,  C12P21/04

CPC分类号： C12N9/6475 ,  A61K38/00 ,  C12N9/6421

摘要： There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: R1-Asp-R2-R3 wherein R1 and R3 are independently any D or L isomer amino acid, R2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1β protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.

摘要翻译： 公开了一种分离的多肽及其衍生物，其对于人前体IL-1β和底物具有蛋白酶生物学活性，其包含：<？in-line-formula description =“In-line formula”end =“lead”？> R _{1-in-line-formula description =“In-line Formulas”end =“tail”？> 其中R 1和R 3独立地是任何D或L异构体氨基酸，R 2是Ala或Gly，并且其中特异性蛋白酶裂解 位于Asp和R 2 2之间。 还公开了抑制白细胞介素1β蛋白酶活性的抑制剂化合物，组合物和方法。 抑制剂化合物包含具有N-末端封闭基团的1至约5个氨基酸的氨基酸序列和与电负离子基团连接的C末端Asp残基，其中氨基酸序列对应于序列Ala-Tyr- Val-His-Asp。}

公开(公告)号：US20060069054A1

公开(公告)日：2006-03-30

申请号：US11226869

申请日：2005-09-13

申请人： Raymond Houghton ,  Paul Sleath ,  David Persing

发明人： Raymond Houghton ,  Paul Sleath ,  David Persing

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K16/3015 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/4748 ,  C07K2317/34 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2500/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.