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公开(公告)号：US08666680B2
公开(公告)日：2014-03-04
申请号：US13272253
申请日：2011-10-13
申请人： Peter Sondermann , Robert Huber , Uwe Jacob
发明人： Peter Sondermann , Robert Huber , Uwe Jacob
IPC分类号： G01N23/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycoslyation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host ells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modeling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that an be used to separate and/or enrich antibodies.
摘要翻译： 根据本发明的重组可溶性Fc受体的特征在于不存在跨膜结构域，信号肽和糖基化。 通过在原核宿主细胞中表达各自的核酸和所获得的包涵体的复性，可以容易地获得这样的Fc受体，该程序导致非常均匀和纯的产物。 该产品可用于诊断以及药物应用，也可用于生成晶体结构数据。 这种晶体结构数据可用于人造分子的建模。 另一个实施方案包括将根据本发明的Fc受体与用于分离和/或富集抗体的固体材料如色谱材料偶联。
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公开(公告)号：US20080014141A1
公开(公告)日：2008-01-17
申请号：US10580813
申请日：2004-11-26
申请人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
发明人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
IPC分类号： A61K39/395 , A61K38/00 , A61K49/00 , A61P37/00 , C07K14/00 , C12N15/63 , C12N5/10 , C07K16/00 , C07H21/04 , A61P19/02 , A61K39/00
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcγRIIb or FcγIIa.
摘要翻译： 本发明涉及携带构象鉴别表位（CDEs）的新型免疫原和用于产生特异性识别与非常密切相关的同系物的蛋白质的抗体的免疫方法。 特别地，本发明涉及对FcgammaRIIb或FcgammaIIa特异的抗体。
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公开(公告)号：US08853363B2
公开(公告)日：2014-10-07
申请号：US10580813
申请日：2004-11-26
申请人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
发明人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcγRIIb or FcγRIIa.
摘要翻译： 本发明涉及携带构象鉴别表位（CDEs）的新型免疫原和用于产生特异性识别与非常密切相关的同系物的蛋白质的抗体的免疫方法。 特别地，本发明涉及对FcγRIIb或FcγRIIa特异的抗体。
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公开(公告)号：US20080214459A1
公开(公告)日：2008-09-04
申请号：US11971438
申请日：2008-01-09
申请人： Robert Huber , Peter Sondermann , Uwe Jacob
发明人： Robert Huber , Peter Sondermann , Uwe Jacob
CPC分类号： A61K38/1774
摘要： The present invention concerns pharmaceutical compositions containing one of the receptors FcγR IIa, FcγR IIb or FcγR III in a recombinantly produced, soluble form and their use to treat diseases or conditions which are caused by overshooting immune reactions and a pathologically increased formation of antibodies, in particular of autoantibodies. Multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis are particularly important fields of application.
摘要翻译： 本发明涉及含有重组产生的可溶形式的受体FcγRIIa，FcγRIIb或FcγRIII之一的药物组合物及其用于治疗由过度免疫反应和病理增加的抗体形成引起的疾病或病症的用途， 特别是自身抗体。 多发性硬化，系统性红斑狼疮和类风湿性关节炎是特别重要的应用领域。
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公开(公告)号：US20090292113A1
公开(公告)日：2009-11-26
申请号：US12381719
申请日：2009-03-16
申请人： Peter Sondermann , Robert Huber , Uwe Jacob
发明人： Peter Sondermann , Robert Huber , Uwe Jacob
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.
摘要翻译： 根据本发明的重组可溶性Fc受体的特征在于不存在跨膜结构域，信号肽和糖基化。 通过在原核宿主细胞中表达相应的核酸并获得的包涵体的复性，可容易地获得这样的Fc受体，该程序导致非常均匀和纯的产物。 该产品可用于诊断以及药物应用，也可用于生成晶体结构数据。 这种晶体结构数据可用于人造分子的建模。 另一个实施方案包括将根据本发明的Fc受体偶联到可用于分离和/或富集抗体的固体材料如色谱材料。
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公开(公告)号：US07504482B2
公开(公告)日：2009-03-17
申请号：US11327695
申请日：2006-01-06
申请人： Peter Sondermann , Robert Huber , Uwe Jacob
发明人： Peter Sondermann , Robert Huber , Uwe Jacob
IPC分类号： C07K14/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.
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7.发明申请公开(公告)号：US20120269837A1
公开(公告)日：2012-10-25
申请号：US13492237
申请日：2012-06-08
申请人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
发明人： Robert Huber , Peter Sondermann , Uwe Jacob , Kerstin Wendt , Chiara Cabrele , Luis Moroder
IPC分类号： C07K7/64 , C07K5/12 , C07K16/28 , A61P37/04 , C12N15/11 , C12N15/13 , C12N15/63 , C12N1/00 , C07K2/00 , A61K39/00
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： This invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcγRIIb and FcγRIIa.
摘要翻译： 本发明涉及携带构象鉴别表位（CDEs）的新型免疫原和用于产生特异性识别具有非常密切相关同系物的蛋白质的抗体的免疫方法。 特别地，本发明涉及对FcγRIIb和FcγRIIa特异性的抗体。
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公开(公告)号：US07074896B1
公开(公告)日：2006-07-11
申请号：US09856933
申请日：1999-12-03
申请人： Peter Sondermann , Robert Huber , Uwe Jacob
发明人： Peter Sondermann , Robert Huber , Uwe Jacob
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.
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9.发明申请Pharmaceutical composition containing sFcgammaR IIb or sFcgammaR III 审中-公开含有sFcgammaR IIb或sFcgammaR III的药物组合物公开(公告)号：US20050002924A1
公开(公告)日：2005-01-06
申请号：US10851655
申请日：2004-05-24
申请人： Robert Huber , Peter Sondermann , Uwe Jacob
发明人： Robert Huber , Peter Sondermann , Uwe Jacob
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P37/00 , A61K39/395
CPC分类号： A61K38/1774
摘要： The present invention concerns pharmaceutical compositions containing one of the receptors FcγR IIa, FcγR IIb or FCγR III in a recombinantly produced, soluble form and their use to treat diseases or conditions which are caused by overshooting immune reactions and a pathologically increased formation of antibodies, in particular of autoantibodies. Multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis are particularly important fields of application.
摘要翻译： 本发明涉及含有重组产生的可溶形式的受体FcgammaR IIa，Fcgamma IIb或FCgammaR III之一的药物组合物及其用于治疗由过度免疫反应引起的疾病或病症以及病理学上增加的抗体形成 特别是自身抗体。 多发性硬化，系统性红斑狼疮和类风湿性关节炎是特别重要的应用领域。
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公开(公告)号：US20070207163A1
公开(公告)日：2007-09-06
申请号：US11327695
申请日：2006-01-06
申请人： Peter Sondermann , Robert Ruber , Uwe Jacob
发明人： Peter Sondermann , Robert Ruber , Uwe Jacob
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.
摘要翻译： 根据本发明的重组可溶性Fc受体的特征在于不存在跨膜结构域，信号肽和糖基化。 通过在原核宿主细胞中表达相应的核酸并获得的包涵体的复性，可容易地获得这样的Fc受体，该程序导致非常均匀和纯的产物。 该产品可用于诊断以及药物应用，也可用于生成晶体结构数据。 这种晶体结构数据可用于人造分子的建模。 另一个实施方案包括将根据本发明的Fc受体偶联到可用于分离和/或富集抗体的固体材料如色谱材料。
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