公开(公告)号：US20130320976A1

公开(公告)日：2013-12-05

申请号：US13906635

申请日：2013-05-31

申请人： Robert Krieg ,  Sebastian Schmidt ,  Michael Uder

发明人： Robert Krieg ,  Sebastian Schmidt ,  Michael Uder

IPC分类号： G01R33/32 ,  G01R33/44

CPC分类号： G01R33/32 ,  G01R33/44 ,  G01R33/48 ,  G01R33/4828 ,  G01R33/5607

摘要： In a magnetic resonance method and apparatus to measure a sodium content in tissue in a first slice, a determination of a blood volume in blood vessels in the first slice is made, and an MR acquisition sequence to acquire MR data of a sodium-23 magnetization from the first slice is implemented. A signal proportion of the MR data that originates from the sodium-23 magnetization in blood vessels is calculated based on the determined blood volume in tissue. This signal proportion is subtracted from a total signal of the MR data to obtain a corrected signal that is proportional to the sodium content in tissue. The sodium content in tissue is calculated from the corrected signal.

摘要翻译： 在用于测量第一切片中组织中的钠含量的磁共振方法和装置中，确定第一切片中血管中的血容量，以及MR获取序列，以获取钠-23磁化的MR数据 从第一个切片实现。 基于组织中确定的血液体积计算源自血管中钠-23磁化的MR数据的信号比例。 从MR数据的总信号中减去该信号比例，以获得与组织中的钠含量成比例的校正信号。 从校正的信号计算组织中的钠含量。

公开(公告)号：US20090062630A1

公开(公告)日：2009-03-05

申请号：US12222776

申请日：2008-08-15

申请人： Arne Hengerer ,  Robert Krieg ,  Sebastian Schmidt ,  Ralph Strecker

发明人： Arne Hengerer ,  Robert Krieg ,  Sebastian Schmidt ,  Ralph Strecker

IPC分类号： A61B5/145 ,  C12Q1/00 ,  A61B5/05 ,  A61F2/06

CPC分类号： A61B5/415 ,  A61B5/05 ,  A61B5/06 ,  A61B5/418 ,  A61K49/16 ,  A61K49/18 ,  A61K49/1875 ,  B82Y5/00 ,  G01R33/50 ,  G01R33/5601

摘要： A sensor is disclosed for permitting detection of a substance in the body of a living being. In at least one embodiment, the sensor includes probe molecules, for binding the substance that is to be detected, and marking elements designed in such a way that the binding of the probe molecules to the substance to be detected is detectable by way of an imaging modality. For example, antigens or pathogens that are present only in a low concentration can be detected.

摘要翻译： 公开了用于允许检测生物体内物质的传感器。 在至少一个实施例中，传感器包括用于结合要检测的物质的探针分子和以使得探针分子与待检测物质的结合可通过成像检测的方式设计的标记元件 模态 例如，可以检测出仅存在低浓度的抗原或病原体。

公开(公告)号：US20060250133A1

公开(公告)日：2006-11-09

申请号：US11395251

申请日：2006-04-03

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G06K9/00

CPC分类号： G01R33/481 ,  G01T1/1603

摘要： A positron emission tomography unit (PET), having a unit part assigned to an examination space and a first evaluation unit, is combined with a magnetic resonance tomography unit (MRT). The unit part of the PRT includes at least two gamma ray detector units with in each case an assigned electronics unit. The MRT includes a second evaluation unit, a gradient coil system and a high frequency antenna device formed as a stripline antenna device having at least two conductors. The high frequency antenna device is arranged nearer to the examination space than the gradient coil system with a high frequency shield between the gradient coil system and the high frequency antenna device. Each conductor of the stripline antenna device respectively includes a gamma ray detector unit with an assigned electronics unit. The conductors of the stripline antenna device are configured for the respective gamma ray detector units and their assigned electronics units as shielding covers that are caused by the high frequency antenna device and are opaque to high frequency radiation. An examination object in the examination space can be imaged by the combined positron emission tomography and magnetic resonance tomography unit.

摘要翻译： 将具有分配给检查空间的单位部分和第一评估单元的正电子发射断层摄影单元（PET）与磁共振断层摄影单元（MRT）组合。 PRT的单位部分包括至少两个伽马射线检测器单元，在每种情况下都是分配的电子单元。 MRT包括第二评估单元，梯度线圈系统和形成为具有至少两个导体的带状线天线装置的高频天线装置。 高频天线装置布置成比梯度线圈系统和高频天线装置之间具有高频屏蔽的梯度线圈系统更靠近检查空间。 带状线天线装置的每个导体分别包括具有分配的电子单元的伽马射线检测器单元。 带状线天线装置的导体被配置用于相应的伽马射线检测器单元及其分配的电子单元作为由高频天线装置引起并且对高频辐射不透明的屏蔽盖。 检查空间中的检查对象可以通过组合的正电子发射断层摄影和磁共振断层摄影单元成像。

公开(公告)号：US08508228B2

公开(公告)日：2013-08-13

申请号：US12775686

申请日：2010-05-07

申请人： Robert Krieg ,  Sebastian Schmidt

发明人： Robert Krieg ,  Sebastian Schmidt

IPC分类号： G01V3/00

CPC分类号： A61B5/0555 ,  A61B5/4312 ,  G01R33/34 ,  G01R33/385

摘要： A coil arrangement for a magnetic resonance tomography apparatus has plates that each contain at least one gradient coil.

摘要翻译： 用于磁共振断层摄影装置的线圈装置具有各自包含至少一个梯度线圈的板。

公开(公告)号：US07522952B2

公开(公告)日：2009-04-21

申请号：US11395267

申请日：2006-04-03

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： A61B5/055

CPC分类号： G01T1/1603 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/2985

摘要： A combined PET/MRI tomography unit has a PET unit with a unit part assigned to the examination space, and a first evaluation unit for evaluating the PET electric signals. The unit part has a gamma ray detector. The combined unit has an MRI unit and a second evaluation unit for evaluating MRI signals. The MRI unit has a high frequency antenna as well as a gradient coil system, the high frequency antenna device being arranged nearer to the examination space than the gradient coil system, as well as a high frequency shield arranged between the gradient coil system and the high frequency antenna device. The PET unit part is arranged between the high frequency shield and the high frequency antenna device. A shielding cover for the high frequency antenna device faces the high frequency antenna device. The shielding cover is opaque to high frequency radiation.

摘要翻译： 组合的PET / MRI断层摄影单元具有分配给检查空间的单位部分的PET单元和用于评估PET电信号的第一评估单元。 单位部件具有伽马射线检测器。 组合单元具有用于评估MRI信号的MRI单元和第二评估单元。 MRI单元具有高频天线以及梯度线圈系统，高频天线装置布置成比梯度线圈系统更靠近检查空间，以及布置在梯度线圈系统和高电平之间的高频屏蔽 频率天线装置。 PET单元部分布置在高频屏蔽和高频天线装置之间。 用于高频天线装置的屏蔽罩面向高频天线装置。 屏蔽罩对高频辐射是不透明的。

公开(公告)号：US07482592B2

公开(公告)日：2009-01-27

申请号：US11438208

申请日：2006-05-23

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G01T1/166

CPC分类号： G01T1/2985 ,  A61B6/037 ,  A61B6/507 ,  G01R33/481 ,  G01T1/1603

摘要： A method for determining positron emission measurement information in the context of positron emission tomography is disclosed. The method includes using a marker substance to carry out a positron emission measurement, in a body area of a subject to be examined, to determine positron emission measurement information, and at the same time, generating images of the body area to be examined by way of a second medical method with a time resolution suitable for determining perfusion and/or diffusion information. The method further includes using the images from the second method to determine perfusion and/or diffusion information for at least a part of the measurement period, and evaluating the positron emission measurement information as a function of the perfusion and/or diffusion information.

摘要翻译： 公开了一种在正电子发射断层摄影的背景下确定正电子发射测量信息的方法。 该方法包括使用标记物质进行待检查对象的身体区域中的正电子发射测定，以确定正电子发射测量信息，并且同时生成要检查的身体区域的图像 具有适合于确定灌注和/或扩散信息的时间分辨率的第二医疗方法。 该方法还包括使用来自第二方法的图像来确定至少部分测量周期的灌注和/或扩散信息，以及作为灌注和/或扩散信息的函数来评估正电子发射测量信息。

公开(公告)号：US07683330B2

公开(公告)日：2010-03-23

申请号：US11438209

申请日：2006-05-23

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G01T1/166

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01R33/481

摘要： A method is disclosed for determining positron emission measurement information in the context of positron emission tomography. The method includes carrying out a positron emission measurement, in a body area of a subject to be examined, to record positron emission measurement information with point resolution and determining a time frame of the measurement by, at the same time, generating images of the body area to be examined with a relatively higher time resolution and with point-resolved image data, using a second imaging method. Further, a local shift of points of individual images of the second imaging method is determined, caused by movement processes of the subject to be examined, and as a function thereof, of the positron emission measurement information for at least a part of the measurement period and of the body area to be examined. Finally, the positron emission measurement information is adjusted as a function of the determined shift.

摘要翻译： 公开了一种用于在正电子发射断层摄影的背景下确定正电子发射测量信息的方法。 该方法包括在待检查对象的身体区域中进行正电子发射测量，以记录具有点分辨率的正电子发射测量信息，并且通过同时生成身体的图像来确定测量的时间范围 使用第二成像方法以相对较高的时间分辨率和点分辨图像数据进行检查的区域。 此外，由第二成像方法的各个图像的点的局部偏移由待检查对象的移动处理确定，并且作为其功能，确定至少部分测量周期的正电子发射测量信息 以及要检查的身体区域。 最后，调整正电子发射测量信息作为确定的位移的函数。

公开(公告)号：US07323874B2

公开(公告)日：2008-01-29

申请号：US11395251

申请日：2006-04-03

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G01V3/00

CPC分类号： G01R33/481 ,  G01T1/1603

摘要： A positron emission tomography unit (PET), having a unit part assigned to an examination space and a first evaluation unit, is combined with a magnetic resonance tomography unit (MRT). The unit part of the PRT includes at least two gamma ray detector units with in each case an assigned electronics unit. The MRT includes a second evaluation unit, a gradient coil system and a high frequency antenna device formed as a stripline antenna device having at least two conductors. The high frequency antenna device is arranged nearer to the examination space than the gradient coil system with a high frequency shield between the gradient coil system and the high frequency antenna device. Each conductor of the stripline antenna device respectively includes a gamma ray detector unit with an assigned electronics unit. The conductors of the stripline antenna device are configured for the respective gamma ray detector units and their assigned electronics units as shielding covers that are caused by the high frequency antenna device and are opaque to high frequency radiation. An examination object in the examination space can be imaged by the combined positron emission tomography and magnetic resonance tomography unit.

摘要翻译： 将具有分配给检查空间的单位部分和第一评估单元的正电子发射断层摄影单元（PET）与磁共振断层摄影单元（MRT）组合。 PRT的单位部分包括至少两个伽马射线检测器单元，在每种情况下都是分配的电子单元。 MRT包括第二评估单元，梯度线圈系统和形成为具有至少两个导体的带状线天线装置的高频天线装置。 高频天线装置布置成比梯度线圈系统和高频天线装置之间具有高频屏蔽的梯度线圈系统更靠近检查空间。 带状线天线装置的每个导体分别包括具有分配的电子单元的伽马射线检测器单元。 带状线天线装置的导体被配置用于相应的伽马射线检测器单元及其分配的电子单元作为由高频天线装置引起并且对高频辐射不透明的屏蔽盖。 检查空间中的检查对象可以通过组合的正电子发射断层摄影和磁共振断层摄影单元成像。

公开(公告)号：US20060284096A1

公开(公告)日：2006-12-21

申请号：US11438208

申请日：2006-05-23

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/037 ,  A61B6/507 ,  G01R33/481 ,  G01T1/1603

摘要： A method for determining positron emission measurement information in the context of positron emission tomography is disclosed. The method includes using a marker substance to carry out a positron emission measurement, in a body area of a subject to be examined, to determine positron emission measurement information, and at the same time, generating images of the body area to be examined by way of a second medical method with a time resolution suitable for determining perfusion and/or diffusion information. The method further includes using the images from the second method to determine perfusion and/or diffusion information for at least a part of the measurement period, and evaluating the positron emission measurement information as a function of the perfusion and/or diffusion information.

摘要翻译： 公开了一种在正电子发射断层摄影的背景下确定正电子发射测量信息的方法。 该方法包括使用标记物质进行待检查对象的身体区域中的正电子发射测定，以确定正电子发射测量信息，并且同时生成要检查的身体区域的图像 具有适合于确定灌注和/或扩散信息的时间分辨率的第二医疗方法。 该方法还包括使用来自第二方法的图像来确定至少部分测量周期的灌注和/或扩散信息，以及作为灌注和/或扩散信息的函数来评估正电子发射测量信息。

公开(公告)号：US20060251312A1

公开(公告)日：2006-11-09

申请号：US11395267

申请日：2006-07-03

申请人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

发明人： Robert Krieg ,  Rainer Kuth ,  Ralf Ladebeck ,  Ralph Oppelt ,  Wolfgang Renz ,  Sebastian Schmidt ,  Markus Vester

IPC分类号： G01V3/00

CPC分类号： G01T1/1603 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01R33/481 ,  G01T1/2985

摘要： Combined positron emission tomography and magnetic resonance tomography unit for imaging an examination object in an examination space, comprising a positron emission tomography unit that has a unit part assigned to the examination space, and a first evaluation unit for evaluating the electric signals for a positron emission tomography image of the examination object. The unit part in this case comprises a gamma ray detector with an assigned electronics unit. Furthermore, the combined unit comprises a magnetic resonance tomography unit and a second evaluation unit for evaluating the magnetic resonance signals for a magnetic resonance image of the examination object. The magnetic resonance unit in this case has a high frequency antenna device as well as a gradient coil system, the high frequency antenna device being arranged nearer to the examination space than the gradient coil system, as well as a high frequency shield arranged between the gradient coil system and the high frequency antenna device. The positron emission tomography unit part is arranged in this case between the high frequency shield and the high frequency antenna device, and is provided, at least on the side facing the high frequency antenna device, with a shielding cover that is caused by the high frequency antenna device and is opaque to high frequency radiation.

摘要翻译： 组合正电子发射断层摄影和磁共振断层摄影单元，用于对检查空间中的检查对象进行成像，包括具有分配给检查空间的单位部分的正电子发射断层摄影单元和用于评估正电子发射的电信号的第一评估单元 检查对象的断层扫描图像。 这种情况下的单元部分包括具有分配的电子单元的伽马射线检测器。 此外，组合单元包括磁共振断层摄影单元和用于评估检查对象的磁共振图像的磁共振信号的第二评估单元。 在这种情况下，磁共振单元具有高频天线装置以及梯度线圈系统，高频天线装置布置成比梯度线圈系统更靠近检查空间，以及布置在梯度之间的高频屏蔽 线圈系统和高频天线装置。 在这种情况下，正电子发射断层摄影单元部分布置在高频屏蔽和高频天线装置之间，并且至少在面向高频天线装置的一侧上设置有由高频天线装置引起的屏蔽罩 天线装置，对高频辐射是不透明的。