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公开(公告)号：US5242391A
公开(公告)日：1993-09-07
申请号：US787306
申请日：1991-10-30
CPC分类号： A61M31/00 , A61F5/41 , A61K9/0034 , A61M31/002 , A61M2210/167
摘要： Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (1) having a rapidly releasing coating (4) containing the agent on its exterior surface or by means of an inserter (27) carrying an agent containing dose of agent (31) which can be displaced into the urethra.
摘要翻译： 通过经尿道给药治疗有效药物治疗勃起功能障碍，特别是阳ence，阴茎异常勃起和佩罗尼氏病。 通过具有在其外表面上含有该试剂的快速释放的涂层（4）的阴茎插入物（1）或通过携带含有剂量的试剂（31）的试剂的插入器（27）将药剂施用于尿道， 其可以移入尿道。
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2.发明授权Pharmaceutical compositions for treating priapism and peyronie's syndrome 失效用于治疗阴茎异常勃起和白血病综合征的药物组合物
公开(公告)号：US6113939A
公开(公告)日：2000-09-05
申请号：US482366
申请日：1995-06-07
CPC分类号： A61M31/00 , A61F5/41 , A61K9/0034 , A61M31/002 , A61M2210/167
摘要： A composition for the treatment of impotence via delivery to the urethra comprises a vasoactive prostaglandin and a polyethylene glycol dispersant having sufficient viscosity to be retained without spillage from a urethra receivable insert. The composition can additionally contain an .alpha.-blocker. Suppositories can be formulated that are small enough for administration to the male urethra, and that dissolve, melt or bioerode within the urethra to release the active agent(s). The suppositories can contain vasodilators other than prostaglandins as the active for the treatment of impotence. Suppositories can also be formulated that contain active agents useful in the treatment of priapism or Peyronie's syndrome.
摘要翻译： 用于通过递送至尿道治疗阳A的组合物包括血管活性前列腺素和具有足够粘度的聚乙二醇分散剂，其不会从尿道可接收的插入物中溢出而被保留。 该组合物可另外含有α-阻滞剂。 栓剂可以配制成足够小以用于给予男性尿道，并且在尿道内溶解，熔化或生物代谢以释放活性剂。 栓剂可以含有除前列腺素之外的血管扩张剂作为治疗阳the的活性物质。 也可以配制栓剂，其含有用于治疗阴茎异常勃起或佩罗尼氏综合征的活性剂。
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公开(公告)号：US5474535A
公开(公告)日：1995-12-12
申请号：US093545
申请日：1993-07-19
CPC分类号： A61M31/00 , A61F5/41 , A61K9/0034 , A61M31/002 , A61M2210/167
摘要： Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (40) having a shaft with a deformable distal end which forms a dose receiving cavity when an internal piston is retracted relative to the shaft.
摘要翻译： 通过经尿道给药治疗有效药物治疗勃起功能障碍，特别是阳ence，阴茎异常勃起和佩罗尼氏病。 通过具有可变形远端的轴的阴茎插入物（40）将这些药剂施用于尿道，当内部活塞相对于轴缩回时，其形成剂量接收腔。
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公开(公告)号：US06375978B1
公开(公告)日：2002-04-23
申请号：US09213213
申请日：1998-12-17
申请人： Lothar W. Kleiner , Robert M. Gale , Randall G. Berggren , Gilbert T. Tong , Guohua Chen , Keith E. Dionne , Paul R. Houston
发明人： Lothar W. Kleiner , Robert M. Gale , Randall G. Berggren , Gilbert T. Tong , Guohua Chen , Keith E. Dionne , Paul R. Houston
IPC分类号： A61K970
CPC分类号： A61K9/7084 , A61K9/0004
摘要： This invention provides rate controlling membranes for controlled drug delivery devices that are stable over time and exhibit more predictable and consistent membrane functionality. According to another aspect, the membranes have enhanced permeability. According to the invention, the rate controlling membrane of a controlled drug delivery device is subjected to a pre-treatment annealing process wherein it is subjected to an elevated temperature for a predetermined time period and subsequently cooled to ambient conditions before incorporation into a controlled drug delivery device.
摘要翻译： 本发明提供了用于受控药物递送装置的速率控制膜，其随时间稳定并且表现出更可预测和一致的膜功能性。 根据另一方面，膜具有增强的渗透性。 根据本发明，受控药物递送装置的速率控制膜经受预处理退火过程，其中将其经受一段预定时间的升高温度，随后在并入受控药物递送之前冷却至环境条件 设备。
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公开(公告)号：US6093181A
公开(公告)日：2000-07-25
申请号：US481738
申请日：1995-06-07
CPC分类号： A61M31/00 , A61F5/41 , A61K9/0034 , A61M31/002 , A61M2210/167
摘要： Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (1) having a rapidly releasing coating (4) containing the agent on its exterior surface or by means of an inserter (27) carrying an agent containing dose of agent (31) which can be displaced into the urethra.
摘要翻译： 通过经尿道给药治疗有效药物治疗勃起功能障碍，特别是阳ence，阴茎异常勃起和佩罗尼氏病。 通过具有在其外表面上含有该试剂的快速释放的涂层（4）的阴茎插入物（1）或通过携带含有剂量的试剂（31）的试剂的插入器（27）将药剂施用于尿道， 其可以移入尿道。
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公开(公告)号：US5773020A
公开(公告)日：1998-06-30
申请号：US959739
申请日：1997-10-28
CPC分类号： A61M31/00 , A61F5/41 , A61K9/0034 , A61M31/002 , A61M2210/167
摘要： Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (1) having a rapidly releasing coating (4) containing the agent on its exterior surface or by means of an inserter (27) carrying an agent containing dose of agent (31) which can be displaced into the urethra.
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7.发明授权Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes 失效用于在高透皮通量下输送硝酸甘油的透皮递送系统
公开(公告)号：US4681584A
公开(公告)日：1987-07-21
申请号：US869548
申请日：1986-06-02
CPC分类号： A61K9/7084 , A61K31/21
摘要： A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
摘要翻译： 公开了一种高通量透皮硝酸甘油治疗系统，其能够以40μg/ cm 2小时，优选在50-150μg/ cm 2小时的范围内以完整的人体皮肤递送硝酸甘油。 作为硝酸甘油的渗透促进剂，使用乙酸乙烯酯含量大于11％，优选12-18％的醋酸乙烯酯形成的速率控制膜，以250-500μg/ 为药物和渗透增强剂提供适当的速率控制。 该系统适用于治疗心绞痛和充血性心力衰竭。
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8.发明授权Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes 失效用于在高透皮通量下输送硝酸甘油的透皮递送系统
公开(公告)号：US4615699A
公开(公告)日：1986-10-07
申请号：US730714
申请日：1985-05-03
IPC分类号： A61K31/045 , A61K9/70 , A61K31/21 , A61P9/00 , A61K9/00
CPC分类号： A61K9/7084 , A61K31/21 , Y10S514/964
摘要： A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
摘要翻译： 公开了一种高通量透皮硝酸甘油治疗系统，其能够以40μg/ cm 2·小时的速率将完整的人体皮肤递送硝酸甘油，优选在50-150μg/ cm 2·小时的范围内。 乙酸乙酯的乙酸乙烯酯含量大于11％，优选为12-18％，由乙酸乙烯酯形成的速率控制膜用作乙酸甘油的渗透促进剂，乙酸乙酯以250-500μg/ 药物和渗透增强剂的适当速率控制。 该系统适用于治疗心绞痛和充血性心力衰竭。
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公开(公告)号：US08440220B2
公开(公告)日：2013-05-14
申请号：US10420428
申请日：2003-04-22
申请人： Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
发明人： Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
IPC分类号： A61K9/70
CPC分类号： A61K9/7092 , A61K9/7061 , A61K31/4468 , A61K31/4535 , A61K45/06 , A61K2300/00
摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.
摘要翻译： 一种具有降低的滥用可能性的透皮镇痛系统，其中所述系统以足以在剂型受到滥用时提供拮抗剂与镇痛剂的滥用限制释放速率比的速率提供拮抗剂的受控释放。
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公开(公告)号：US20120310187A1
公开(公告)日：2012-12-06
申请号：US13311437
申请日：2011-12-05
申请人： Robert M. Gale
发明人： Robert M. Gale
IPC分类号： A61M35/00
CPC分类号： A61K31/465 , A61K9/0014 , A61K9/7023 , A61K9/703 , A61K9/7084 , A61K31/4465 , A61K47/32 , A61K47/34 , A61K2800/262
摘要： A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
摘要翻译： 用于输送不透明度指数小于48.6％的尼古丁的透明透皮递送装置。
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