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19 条记录 (耗时 0.04 秒)

    INJECTABLE, NONAQUEOUS SUSPENSION WITH HIGH CONCENTRATION OF THERAPEUTIC AGENT
    5.
    发明申请
    INJECTABLE, NONAQUEOUS SUSPENSION WITH HIGH CONCENTRATION OF THERAPEUTIC AGENT 审中-公开
    注意事项，治疗药物浓度高的非标准悬浮液

    公开(公告)号：US20090022727A1

    公开(公告)日：2009-01-22

    申请号：US12020372

    申请日：2008-01-25

    申请人： Paul R. Houston ,  Guohua Chen ,  Andrew Sheung-King Luk

    发明人： Paul R. Houston ,  Guohua Chen ,  Andrew Sheung-King Luk

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： A61K47/44 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/19 ,  A61K38/385 ,  A61K38/47 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/94 ,  C12Y302/01017

    摘要： An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

    摘要翻译： 包含悬浮在单一成分载体中的至少一种治疗剂的可注射非水悬浮液。 单组分载体是单个两亲性材料，例如聚乙氧基化蓖麻油或其衍生物，聚氧乙烯烷基醚，聚氧乙烯山梨糖醇酐脂肪酸酯，聚氧乙烯硬脂酸酯，聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷的嵌段共聚物， 聚氧化丙烯 - 聚环氧乙烷 - 聚环氧丙烷的嵌段共聚物，聚氧化乙烯 - 聚氧化丙烯的四官能嵌段共聚物，或聚氧化丙烯 - 聚环氧乙烷的四官能性嵌段共聚物。 还公开了包含可注射的非水悬浮液的剂量试剂盒和施用可注射的非水悬浮液的方法。

    Injectable Depot Compositions and Uses Thereof
    6.
    发明申请
    Injectable Depot Compositions and Uses Thereof 审中-公开
    可注射仓库组合物及其用途

    公开(公告)号：US20130108681A1

    公开(公告)日：2013-05-02

    申请号：US13593371

    申请日：2012-08-23

    申请人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

    发明人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

    IPC分类号： A61K9/00

    CPC分类号： A61K38/1858 ,  A61K9/0002 ,  A61K9/0024 ,  A61K9/1617 ,  A61K31/445 ,  A61K38/27 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

    摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.

    摘要翻译： 提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物已经显着改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

    Catheter injectable depot compositions and uses thereof
    10.
    发明授权
    Catheter injectable depot compositions and uses thereof 失效
    导管可注射药剂组合物及其用途

    公开(公告)号：US07829109B2

    公开(公告)日：2010-11-09

    申请号：US10295603

    申请日：2002-11-14

    申请人： Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John Spaltro

    发明人： Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John Spaltro

    IPC分类号： A61F2/02

    CPC分类号： A61K9/0024 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

    摘要： Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

    摘要翻译： 提供导管可注射贮库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中具有小于或等于7重量％的混溶性的溶剂。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。