公开(公告)号：US07497994B2

公开(公告)日：2009-03-03

申请号：US10792020

申请日：2004-03-03

申请人： Khushroo Gandhi ,  Gilbert T. Tong

发明人： Khushroo Gandhi ,  Gilbert T. Tong

IPC分类号： B01L3/02

CPC分类号： B29C66/322 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B29C65/48 ,  B29C65/4845 ,  B29C65/4895 ,  B29C66/54 ,  B29C66/71 ,  B29C66/723 ,  B29C66/72321 ,  B29C66/72325 ,  B29C66/72326 ,  B29L2031/756 ,  G01N27/44791 ,  G01N2035/00148 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575 ,  B29K2083/00 ,  B29K2081/06 ,  B29K2069/00 ,  B29K2055/02 ,  B29K2033/12 ,  B29K2027/18 ,  B29K2027/16 ,  B29K2027/06 ,  B29K2025/06 ,  B29K2023/38 ,  B29K2023/18 ,  B29K2023/12 ,  B29K2023/06

摘要： The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports or wells disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. First and second rings are preferentially disposed between the cover layer and the body structure and located circumferentially around each of the apertures of the cover layer. An annular groove is also preferentially disposed between the ring structures to help further minimize the leakage of adhesive or other bonding material into the ports or wells of the device when the cover layer is mated to the body structure.

摘要翻译： 本发明提供了包括主体结构的微流体装置，其包括至少设置在其中的第一微量通道网络。 身体结构具有设置在体结构中的多个端口或孔，其中每个端口与第一通道网络中的一个或多个通道流体连通。 这些装置还包括覆盖层，其包括穿过覆盖层设置的多个孔。 覆盖层与主体结构配合，由此每个孔与多个端口中的单独一个对准。 第一和第二环优选地设置在覆盖层和主体结构之间并且周向地围绕覆盖层的每个孔定位。 环形槽也优先设置在环结构之间，以帮助进一步最小化当覆盖层与本体结构配合时粘合剂或其它结合材料泄漏到装置的端口或孔中。

公开(公告)号：US06375978B1

公开(公告)日：2002-04-23

申请号：US09213213

申请日：1998-12-17

申请人： Lothar W. Kleiner ,  Robert M. Gale ,  Randall G. Berggren ,  Gilbert T. Tong ,  Guohua Chen ,  Keith E. Dionne ,  Paul R. Houston

发明人： Lothar W. Kleiner ,  Robert M. Gale ,  Randall G. Berggren ,  Gilbert T. Tong ,  Guohua Chen ,  Keith E. Dionne ,  Paul R. Houston

IPC分类号： A61K970

CPC分类号： A61K9/7084 ,  A61K9/0004

摘要： This invention provides rate controlling membranes for controlled drug delivery devices that are stable over time and exhibit more predictable and consistent membrane functionality. According to another aspect, the membranes have enhanced permeability. According to the invention, the rate controlling membrane of a controlled drug delivery device is subjected to a pre-treatment annealing process wherein it is subjected to an elevated temperature for a predetermined time period and subsequently cooled to ambient conditions before incorporation into a controlled drug delivery device.

摘要翻译： 本发明提供了用于受控药物递送装置的速率控制膜，其随时间稳定并且表现出更可预测和一致的膜功能性。 根据另一方面，膜具有增强的渗透性。 根据本发明，受控药物递送装置的速率控制膜经受预处理退火过程，其中将其经受一段预定时间的升高温度，随后在并入受控药物递送之前冷却至环境条件 设备。