公开(公告)号：US5405317A

公开(公告)日：1995-04-11

申请号：US938033

申请日：1992-10-30

申请人： Robert M. Myers ,  Mark G. Stahl ,  Felix A. Landrau ,  J. Richard Gyory

发明人： Robert M. Myers ,  Mark G. Stahl ,  Felix A. Landrau ,  J. Richard Gyory

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0448

摘要： An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a preferably hydrophobic polymeric matrix. The matrix contains about 10 to 50 vol % of a material capable of absorbing a liquid solvent, typically water, to provide a plurality of ion conducting pathways through the matrix. The matrix also contains about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the solvent absorbing material is a hydrophilic polymer such as polyvinylpyrrolidone. For the anodic electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathodic electrode, the chemical species should be able to undergo reduction and is preferably silver chloride or a reducible metal.

摘要翻译： PCT No.PCT / US91 / 03164 Sec。 371日期：1992年10月30日 102（e）日期1992年10月30日PCT 1991年5月7日PCT PCT。 第WO91 / 16946号公报 日期为1991年11月14日。提供电动离子电渗输送装置。 该装置使用由优选疏水性聚合物基质构成的电极。 该基质含有约10至50vol％的能够吸收液体溶剂（通常为水）的材料，以提供穿过基质的多个离子传导途径。 该基质还含有约5至40体积％的化学物质，其能够在装置的操作期间经历氧化或还原。 溶剂吸收材料优选为聚乙烯吡咯烷酮等亲水性聚合物。 对于阳极电极，化学物质应该能够经历氧化，并且优选是银或锌。 对于阴极电极，化学物质应该能够还原，并且优选为氯化银或可还原金属。

公开(公告)号：US5288289A

公开(公告)日：1994-02-22

申请号：US881909

申请日：1992-05-12

申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0448 ,  A61N1/044

摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

摘要翻译： 提供了干态离子电渗药物输送装置（10,70,80）。 该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。 提供含液囊（21,22）。 在某些实施方案中，液体包含在小袋内的可破坏胶囊中。 水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。 或者，可以使用袋刺穿销（36,37）从袋（21,22）释放液体。 从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。 在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。 提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

公开(公告)号：US5320598A

公开(公告)日：1994-06-14

申请号：US881953

申请日：1992-05-12

申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0448 ,  A61N1/044

摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

公开(公告)号：US06317629B1

公开(公告)日：2001-11-13

申请号：US08351381

申请日：1994-12-02

申请人： Ronald P. Haak ,  J. Richard Gyory ,  Robert M. Myers ,  Felix A. Landrau ,  Harold F. Sanders ,  Lothar W. Kleiner ,  Linda M. Hearney

发明人： Ronald P. Haak ,  J. Richard Gyory ,  Robert M. Myers ,  Felix A. Landrau ,  Harold F. Sanders ,  Lothar W. Kleiner ,  Linda M. Hearney

IPC分类号： A61N130

CPC分类号： A61N1/0436 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/303

摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

摘要翻译： 提供了一种离子电渗疗法输送装置（10）。 设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。 装置（10）还包括一对电极组件（18,19）。 使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。 粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。 在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。 在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。

公开(公告)号：US5158537A

公开(公告)日：1992-10-27

申请号：US605046

申请日：1990-10-29

申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Felix A. Landrau ,  Nathan Roth ,  Robert M. Myers

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0448 ,  A61N1/044

摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).

摘要翻译： 提供了干态离子电渗药物输送装置（10,70,80）。 该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。 提供含液囊（21,22）。 在某些实施方案中，液体包含在小袋内的可破坏胶囊中。 水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。 或者，可以使用袋刺穿销（36,37）从袋（21,22）中释放液体。 从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。 在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。 提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

公开(公告)号：US5618265A

公开(公告)日：1997-04-08

申请号：US592083

申请日：1996-01-26

申请人： Robert M. Myers ,  Felix A. Landrau

发明人： Robert M. Myers ,  Felix A. Landrau

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61N1/0436 ,  A61N1/0448

摘要： An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9 ) composed of a substantially homogenous blend of a polymeric matrix containing about 5 to 50 vol % of a conductive filler which forms a conductive network through the matrix, and up to about 50 vol % of the agent to be iontophoretically delivered through the skin. In the case of the donor electrode assembly, the agent is typically a drug and preferably a water soluble drug salt. In the case of the counter electrode assembly, the agent is typically an electrolyte salt. The homogenous blend eliminates the need for separate electrode and agent containing layers which require lamination.

摘要翻译： 提供电动透皮离子电渗递送装置（10,20）及其制造方法。 该装置利用电极组件（8,9），该电极组件由包含约5至50体积％的导电填料的聚合物基质的基本上均匀的共混物构成，该导电填料通过基质形成导电网络，并且至多约50体积％ 通过皮肤离子电渗输送。 在供体电极组件的情况下，试剂通常是药物，优选水溶性药物盐。 在反电极组件的情况下，试剂通常是电解质盐。 均匀的共混物消除了对需要层压的单独的电极和含有层的层的需要。

公开(公告)号：US5543098A

公开(公告)日：1996-08-06

申请号：US197665

申请日：1994-02-17

申请人： Robert M. Myers ,  Felix A. Landrau

发明人： Robert M. Myers ,  Felix A. Landrau

IPC分类号： A61N1/30 ,  C04B35/00

CPC分类号： A61N1/30 ,  A61N1/0436 ,  A61N1/0448

摘要： An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9) composed of a substantially homogenous blend of a polymeric matrix containing about 5 to 50 vol % of a conductive filler which forms a conductive network through the matrix, and up to about 50 vol % of the agent to be iontophoretically delivered through the skin. In the case of the donor electrode assembly, the agent is typically a drug and preferably a water soluble drug salt. In the case of the counter electrode assembly, the agent is typically an electrolyte salt. The homogenous blend eliminates the need for separate electrode and agent containing layers which require lamination.

摘要翻译： 提供电动透皮离子电渗递送装置（10,20）及其制造方法。 该装置利用电极组件（8,9），该电极组件由包含约5至50体积％的导电填料的聚合物基质的基本上均匀的共混物组成，导电填料通过基体形成导电网络，并且至多约50vol％的试剂 通过皮肤离子电渗输送。 在供体电极组件的情况下，试剂通常是药物，优选水溶性药物盐。 在反电极组件的情况下，试剂通常是电解质盐。 均匀的共混物消除了对需要层压的单独的电极和含有层的层的需要。

公开(公告)号：US5385543A

公开(公告)日：1995-01-31

申请号：US85466

申请日：1993-06-30

申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Robert M. Myers

发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Robert M. Myers

IPC分类号： A61N20060101 ,  A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0448 ,  A61N1/044

摘要： A dry-state iontophoretic drug delivery device (10, 20) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of the invention, a passageway (21, 22) is provided through the backing layer (13) and the electrode layer (11, 12) of both the donor electrode assembly (8) and the counter electrode assembly (9). Water or other liquid can be introduced through these passageways (21, 22) in order to hydrate the drug and electrolyte reservoirs (15, 16) and activate the device (10). In another embodiment of the device (20), the drug and electrolyte reservoirs (15, 16) are initially separated from their respective electrodes (11, 12). After the reservoirs (15, 16) are hydrated, they are placed in electrical contact with their respective electrodes (11, 12). By joining the reservoir (15, 16) to the electrode (11, 12) after hydration occurs, delamination problems are reduced.

摘要翻译： 提供了干态离子电渗药物输送装置（10,20）。 该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。 在本发明的一个实施例中，通过支撑层（13）和施主电极组件（8）和对电极组件（9）的电极层（11,12）提供通道（21,22）。 水或其它液体可以通过这些通道（21,22）引入，以便水合药物和电解质储存器（15,16）并激活装置（10）。 在装置（20）的另一个实施例中，药物和电解质储存器（15,16）最初与它们各自的电极（11,12）分离。 在储存器（15,16）水合之后，它们与它们各自的电极（11,12）电接触。 通过在水合发生之后将储存器（15,16）连接到电极（11,12），降低了层叠问题。

公开(公告)号：US5147297A

公开(公告)日：1992-09-15

申请号：US521761

申请日：1990-05-07

申请人： Robert M. Myers ,  Mark G. Stahl

发明人： Robert M. Myers ,  Mark G. Stahl

IPC分类号： A61N20060101 ,  A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/30

摘要： An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a polymeric matrix containing about 5 to 40 vol % of a conductive filler which forms a conductive network through the matrix, and about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the conductive filler is carbon or graphite fibers. For the anode electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathode electrode, the chemical species should be able to undergo reduction and is preferably silver chloride.

摘要翻译： 提供电动离子电渗输送装置。 该装置使用由含有约5至40体积％的通过基质形成导电网络的导电填料的聚合物基质和约5至40体积％的能够经历氧化或还原过程中的化学物质的电极组成的电极 设备的操作。 优选地，导电填料是碳或石墨纤维。 对于阳极电极，化学物质应该能够经历氧化，并且优选地是银或锌。 对于阴极，化学物质应该能够还原，优选氯化银。

公开(公告)号：US5466217A

公开(公告)日：1995-11-14

申请号：US222122

申请日：1994-04-04

申请人： Robert M. Myers ,  Ronald P. Haak ,  Richard W. Plue

发明人： Robert M. Myers ,  Ronald P. Haak ,  Richard W. Plue

IPC分类号： A61N1/30

CPC分类号： A61N1/0428

摘要： An iontophoretic agent delivery device having a simplified structure and ease of manufacture. The device utilizes an electrical pathway comprising a source of electrical energy and an output means. The electrical pathway is disposed upon one of the two sides of a flexible, non-conductive substrate (e.g., a film). The output means of the pathway are connected directly or indirectly, e.g., by means of an electrically conductive adhesive tape, to the remaining components of the device such as current distribution members, lead wires, or electrodes. In this arrangement, the circuit is inverted from that of conventional devices. Economical, reel-to-reel methods of manufacturing a one-sided iontophoretic circuit apparatus of the invention are disclosed.

摘要翻译： 具有简化的结构和易于制造的离子电渗剂递送装置。 该装置利用包括电能源的电路和输出装置。 电路设置在柔性非导电衬底（例如膜）的两侧之一上。 路径的输出装置例如通过导电胶带直接或间接地连接到装置的其余部件，例如电流分配构件，引线或电极。 在这种布置中，电路与常规器件的电路相反。 公开了制造本发明的单面离子电渗回路装置的经济的卷对卷方法。