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    Platelet aggregation inhibitors
    1.
    发明授权
    Platelet aggregation inhibitors 失效
    血小板聚集抑制剂

    公开(公告)号：US5318899A

    公开(公告)日：1994-06-07

    申请号：US483229

    申请日：1990-02-20

    申请人： Robert M. Scarborough ,  David L. Wolf ,  Israel F. Charo

    发明人： Robert M. Scarborough ,  David L. Wolf ,  Israel F. Charo

    IPC分类号： A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C12P21/06

    CPC分类号： C07K14/75 ,  A61K38/12 ,  A61K38/1703 ,  A61K38/57 ,  C07K14/46 ,  C07K14/755 ,  C07K14/78

    摘要： An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K.sup.* -(G/Sar)-D wherein K.sup.* is a modified lysyl residue of the formulaR.sup.1.sub.2 N(CH.sub.2).sub.4 CHNHCO--wherein each R.sup.1 is independently H, alkyl(1-6C) or at most one R.sup.1 is R.sup.2 --C.dbd.NR.sup.3 wherein R.sup.2 is H, alkyl(1-6C) or is NR.sup.4.sub.2 in which each R.sup.4 is independently H or alkyl(1-6C) and R.sup.3 is H, alkyl(1-6C), phenyl or benzyl, or R.sup.2 --C=NR.sup.3 is a radical selected from the group consisting of: ##STR1## where m is an integer of 2-3, and each R.sup.5 is independently H or alkyl(1-6C);and wherein one or two (CH.sub.2) may be replaced by O or S provided said O or S is not adjacent to another heteroatomare prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

    摘要翻译： 描述了基于特异性受体结合筛选蛇毒用于存在或不存在血小板聚集抑制剂（PAI）的测定法。 使用该测定，完成了广泛的蛇毒样品中PAIs的鉴定和表征。 描述和表征了来自这些活性蛇毒中的几种的分离和纯化的PAI。 另外，缺少Arg-Gly-Asp（RGD）粘附序列但含有K * - （G / Sar）-D的PAI，其中K *是式R12N（CH2）4CHNHCO-的修饰的赖氨酰残基，其中每个R 1独立地 H，烷基（1-6C）或至多一个R1是R2-C = NR3，其中R2是H，（1-6C）烷基或NR42，其中每个R4独立地是H或烷基（1-6C），R3是 H，烷基（1-6C），苯基或苄基，或R2-C = NR3是选自以下的基团：其中m是2-3的整数，并且每个R 5独立地为 H或烷基（1-6C）; 并且其中一个或两个（CH 2）可以被O或S替代，条件是所述O或S不与另一个杂原子相邻，并且显示出特异性抑制纤维蛋白原或血管性血友病因子与GP IIb-IIIa的结合。

    Genes encoding platelet aggregation inhibitors
    2.
    发明授权
    Genes encoding platelet aggregation inhibitors 失效
    编码血小板聚集抑制剂的基因

    公开(公告)号：US5496724A

    公开(公告)日：1996-03-05

    申请号：US67139

    申请日：1993-05-24

    申请人： Robert M. Scarborough ,  David L. Wolf ,  Israel F. Charo

    发明人： Robert M. Scarborough ,  David L. Wolf ,  Israel F. Charo

    IPC分类号： A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C12N1/19 ,  C12N15/71

    CPC分类号： C07K14/75 ,  A61K38/12 ,  A61K38/1703 ,  A61K38/57 ,  C07K14/46 ,  C07K14/755 ,  C07K14/78

    摘要： An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formulaR.sup.1.sub.2 N(CH.sub.2).sub.4 CHNHCO--wherein each R.sup.1 is independently H, alkyl(1-6C) or at most one R.sup.1 is R.sup.2 --C.dbd.NR.sup.3 wherein R.sup.2 is H, alkyl(1-6C) or is NR.sup.4.sub.2 in which each R.sup.4 is independently H or alkyl(1-6C) and R.sup.3 is H, alkyl(1-6C), phenyl or benzyl, or R.sup.2 --C.dbd.NR.sup.3 is a radical selected from the group consisting of: ##STR1## where m is an integer of 2-3, and each R.sup.5 is independently H or alkyl(1-6C);and wherein one or two (CH.sub.2) may be replaced by O or S provided said O or S is not adjacent to another heteroatomare prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

    摘要翻译： 描述了基于特异性受体结合筛选蛇毒用于存在或不存在血小板聚集抑制剂（PAI）的测定法。 使用该测定，完成了广泛的蛇毒样品中PAIs的鉴定和表征。 描述和表征了来自这些活性蛇毒中的几种的分离和纯化的PAI。 另外，缺少Arg-Gly-Asp（RGD）粘附序列但含有K * - （G / Sar）-D的PAI，其中K *是式R12N（CH2）4CHNHCO-的修饰的赖氨酰残基，其中每个R 1独立地 H，烷基（1-6C）或至多一个R1是R2-C = NR3，其中R2是H，（1-6C）烷基或NR42，其中每个R4独立地是H或烷基（1-6C），R3是 H，烷基（1-6C），苯基或苄基，或R2-C = NR3是选自以下的基团：其中m是2-3的整数，并且每个R 5独立地是H或烷基 （1-6C）; 并且其中一个或两个（CH 2）可以被O或S替代，条件是所述O或S不与另一个杂原子相邻，并且显示出特异性抑制纤维蛋白原或血管性血友病因子与GP IIb-IIIa的结合。

    Apparatus for feeding and opening a beverage carrier
    3.
    发明授权
    Apparatus for feeding and opening a beverage carrier 失效
    用于进料和打开饮料载体的装置

    公开(公告)号：US4709538A

    公开(公告)日：1987-12-01

    申请号：US861470

    申请日：1986-05-09

    申请人： Peter C. Olsen, Jr. ,  Peter M. Conforto ,  Jimmy R. Craighead ,  David L. Wolf

    发明人： Peter C. Olsen, Jr. ,  Peter M. Conforto ,  Jimmy R. Craighead ,  David L. Wolf

    IPC分类号： B65B43/34 ,  B31B1/78 ,  B31B5/78 ,  B65B20060101 ,  B65B43/26 ,  B65B43/24

    CPC分类号： B31B1/00 ,  B31B2201/281 ,  B31B2203/003

    摘要： A machine for feeding a collapsed beverage can carrier sleeve to a flight bar conveyor and introducing the sleeve in fully open condition to the pocket of the conveyor. After leaving the feed rolls the collapsed carrier sleeve is moved through a fixed guide by lugs on a movable chain. The end flaps on the upwardly facing side panel are held in place on the guide while the end flaps on the downwardly facing side panel are moved downwardly by a fixed cam surface. The substantially opened sleeve is then either given a final kick by rotating arms or is propelled by the feed lugs to accelerate it into the pocket while at the same time fully straightening and opening the sleeve. The carton dimension corresponding to the length of the pocket is the same as the length of the pocket, resulting in more pockets per conveyor length and permitting operation at slower conveyor speeds.

    摘要翻译： 用于将塌缩的饮料供给的机器可以将承载套筒连接到飞行棒输送机，并将套管完全打开的状态引导到输送机的口袋。 在离开进给辊之后，折叠的载体套筒通过可移动链上的凸耳移动通过固定的引导件。 面向上的侧板上的端部折片被保持在导向件上的适当位置，而面向下的侧板上的端部折片通过固定的凸轮表面向下移动。 然后通过旋转臂给出基本上打开的套筒，或者由进给凸耳推进，以将其加速到口袋中，同时完全拉直和打开套筒。 与口袋长度相对应的纸箱尺寸与口袋的长度相同，导致每个输送机长度更多的口袋，并允许在较慢的输送机速度下进行操作。

    Method and apparatus for feeding containers to a carrier sleeve
    6.
    发明授权
    Method and apparatus for feeding containers to a carrier sleeve 失效
    将容器运送到承载套筒的方法和装置

    公开(公告)号：US4693055A

    公开(公告)日：1987-09-15

    申请号：US915479

    申请日：1986-10-06

    申请人： Peter C. Olsen, Jr. ,  Peter M. Conforto ,  David L. Wolf ,  Donald R. Hudson

    发明人： Peter C. Olsen, Jr. ,  Peter M. Conforto ,  David L. Wolf ,  Donald R. Hudson

    IPC分类号： B65B5/10 ,  B65B20060101 ,  B65B17/02 ,  B65B21/06 ,  B65B21/08 ,  B65B35/54

    CPC分类号： B65B21/06

    摘要： A machine for feeding beverage cans to open-ended carrier sleeves of varying capacities. When loading relatively small carrier sleeves, inboard conveyors and associated metering screws feed groups of cans to a flight bar conveyor which moves the groups through the open ends of the carrier sleeves. When loading relatively large carrier sleeves, outboard conveyors and associated metering screws are also operated after first replacing the inboard screws with screws able to separate cans into larger groups, the same size as those formed by the outboard screws. This arrangement feeds larger groups of cans which are then fed to the larger carrier sleeves. In one embodiment each conveyor comprises a longer upstream conveyor and a shorter downstream conveyor spaced a short distance therefrom to allow the flight bars to travel through the space between the conveyors when moving from the end of their upward run to the beginning of their horizontal downstream run. In another embodiment only the longer upstream conveyor is provided and a support plate is used instead of the downstream conveyor. In this embodiment the gap between the conveyor and the plate is automatically closed by a shuttle mechanism to provide a continuous support surface for the cans as they are pushed toward the carrier sleeves. The cans are able to slide on the surface of the conveyors, enabling the conveyors to be operated at a slightly greater speed than the screws are capable of moving the cans, which results in the cans being positively fed by the conveyors.

    摘要翻译： 一种用于将饮料罐供给到具有不同容量的开口式承载套筒的机器。 当装载相对较小的承载套筒，内侧输送机和相关联的计量螺钉将罐组输送到飞行杆输送机，其将组移动穿过承载套筒的开口端。 当装载相对较大的承载套筒时，在使用能够将罐分离成更大的组的螺钉之后，首先用内侧螺钉更换内侧螺钉之后，还将操作外侧输送机和相关的计量螺钉，其尺寸与外侧螺钉形成的尺寸相同。 这种布置提供较大的罐组，然后将其送入较大的承载套筒。 在一个实施例中，每个输送机包括较长的上游输送机和与其短距离间隔的较短的下游输送机，以允许飞行条从其向上运行的终点移动到其水平下游运行的开始时穿过输送机之间的空间 。 在另一个实施例中，仅提供较长的上游输送机，并且使用支撑板代替下游输送机。 在该实施例中，输送机和板之间的间隙由梭机构自动关闭，以便当它们被推向承载套筒时为罐提供连续的支撑表面。 罐子能够在输送机的表面上滑动，使得输送机能够以比能够移动罐的螺杆略微更大的速度操作，这导致罐被输送机积极地供给。

    Adjustable shear bar for a harvester cutterhead
    7.
    发明授权
    Adjustable shear bar for a harvester cutterhead 失效
    收割机刀头可调剪杆

    公开(公告)号：US4190209A

    公开(公告)日：1980-02-26

    申请号：US921282

    申请日：1978-07-03

    申请人： Harold E. deBuhr ,  Merlyn D. Bass ,  Jerry L. Krafka ,  David L. Wolf ,  Kenneth R. Christopher

    发明人： Harold E. deBuhr ,  Merlyn D. Bass ,  Jerry L. Krafka ,  David L. Wolf ,  Kenneth R. Christopher

    IPC分类号： A01D34/52 ,  A01D34/42 ,  A01D34/53 ,  A01D34/62 ,  A01F29/06 ,  A01F29/09 ,  B02C18/16

    CPC分类号： A01F29/095 ,  A01F29/06

    摘要： A forage harvester has a rotary cylinder type cutterhead mounted in a housing with opposite side walls, crop material being fed into the cutterhead in a generally radial direction over a shear bar adjacent the cutterhead periphery. The shear bar is mounted for fore and aft adjustment toward and away from the cutterhead periphery to maintain the optimum clearance between the cutterhead and the shear bar by means of a mechanism that includes a pair of bell cranks respectively pivotally mounted to support members on the opposite walls, with one end of each bell crank being connected to the shear bar through a fore and aft link while the other end of the bell crank threadably receives the threaded portions of a vertically elongated rod that is rotatably supported adjacent the housing side wall and has an easily accessible head adjacent the top of the housing, whereby rotation of the rod causes the bell crank to rock on its pivot to cause linear fore and aft adjustment of the shear bar. The force exerted through the adjusting mechanism is sufficient to overcome a clamping force exerted by a bolt and nut that clamps the shear bar to the supporting structure at opposite ends of the shear bar without loosening the clamping bolt.

    摘要翻译： 饲料收割机具有安装在具有相对侧壁的壳体中的旋转圆筒型刀头，作物材料沿着与刀盘周边相邻的剪切杆沿大致径向方向进给到刀架中。 安装剪切杆用于前后调整朝向和离开刀架周边，以通过一种机构来保持刀架和剪切杆之间的最佳间隙，该机构包括一对分别枢转地安装在相对的支撑构件上的钟形曲柄 每个钟形曲柄的一端通过前后连杆连接到剪切杆，而钟形曲柄的另一端可螺纹地容纳垂直细长的杆的螺纹部分，该垂直细长的杆可相对于壳体侧壁可旋转地支撑并且具有 邻近壳体顶部的容易接近的头部，由此杆的旋转使钟形曲柄在其枢轴上摇动，从而导致剪切杆的线性前后调节。 通过调节机构施加的力足以克服螺栓和螺母施加的夹紧力，该夹紧力将剪切杆在剪力杆的相对端处夹持在支撑结构上，而不松动夹紧螺栓。