-
公开(公告)号：US08293903B2
公开(公告)日：2012-10-23
申请号：US12795266
申请日：2010-06-07
申请人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
发明人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
IPC分类号： C07D403/04 , C07D403/14 , C07D487/08 , A61K31/506 , A61P25/02
CPC分类号： C07D487/08
摘要： There is provided a compound of Formula I(a) or I(b) or a pharmaceutically acceptable salt thereof, wherein the various substituents are defined herein.
摘要翻译： 提供式I（a）或I（b）的化合物或其药学上可接受的盐，其中各种取代基在本文中定义。
-
公开(公告)号：US20110144129A1
公开(公告)日：2011-06-16
申请号：US12795266
申请日：2010-06-07
申请人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
发明人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
IPC分类号： A61K31/506 , C07D403/14 , A61P3/10
CPC分类号： C07D487/08
摘要： There is provided a compound of Formula I(a) or I(b) or a pharmaceutically acceptable salt thereof, wherein the various substituents are defined herein.
摘要翻译： 提供式I（a）或I（b）的化合物或其药学上可接受的盐，其中各种取代基在本文中定义。
-
公开(公告)号：US20130197008A1
公开(公告)日：2013-08-01
申请号：US13616375
申请日：2012-09-14
申请人： Robert O. HUGHES , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
发明人： Robert O. HUGHES , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
IPC分类号： C07D487/08
CPC分类号： C07D487/08
摘要： There is provided a compound of Formula I(a) or I(b): or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
摘要翻译： 提供式I（a）或I（b）的化合物或其药学上可接受的盐，其中各种取代基在本文中定义。
-
公开(公告)号：US08946413B2
公开(公告)日：2015-02-03
申请号：US13616375
申请日：2012-09-14
申请人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
发明人： Robert O. Hughes , Rajesh V. Devraj , Donald J. Rogier , John I. Trujillo , Steve R. Turner , Wei Huang
IPC分类号： C07D403/04 , C07D403/14 , C07D401/04 , C07D401/14 , C07D241/36 , A61K31/444 , A61K31/4995 , A61K31/501 , A61P13/12 , C07D487/08
CPC分类号： C07D487/08
摘要： There is provided a compound of Formula I(a) or I(b): or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
摘要翻译： 提供式I（a）或I（b）的化合物或其药学上可接受的盐，其中各种取代基在本文中定义。
-
公开(公告)号：US20100173888A1
公开(公告)日：2010-07-08
申请号：US12486443
申请日：2009-06-17
申请人： Atli Thorarensen , John I. Trujillo , Wei Huang , Steve R. Turner , Simon Mantell , Ross Strang , Siew Kuen Yeap
发明人： Atli Thorarensen , John I. Trujillo , Wei Huang , Steve R. Turner , Simon Mantell , Ross Strang , Siew Kuen Yeap
IPC分类号： A61K31/397 , C07D213/56 , C07D401/12 , A61K31/444 , A61K31/44 , A61K31/496 , C07D413/12 , A61K31/5377 , A61K31/553 , A61P11/06
CPC分类号： C07D401/12 , C07D213/82 , C07D405/12 , C07D413/12
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allergic and respiratory conditions.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基在本文中定义为含有这些化合物的组合物以及这些化合物用于治疗过敏和呼吸病症的用途。
-
公开(公告)号：US08067589B2
公开(公告)日：2011-11-29
申请号：US12500133
申请日：2009-07-09
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： C07D237/00 , C07D401/00 , C07D401/04 , A61K31/505
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
-
公开(公告)号：US20080207651A1
公开(公告)日：2008-08-28
申请号：US12032723
申请日：2008-02-18
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： A61K31/506 , C07D471/04 , C07D401/02 , A61K31/505 , A61K31/519
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
-
公开(公告)号：US07902373B2
公开(公告)日：2011-03-08
申请号：US11954799
申请日：2007-12-12
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： A01N43/40 , C07D213/62
CPC分类号： C07D401/12 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
-
9.发明授权Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和异齿酰基吡嗪酮公开(公告)号：US07119094B1
公开(公告)日：2006-10-10
申请号：US10276174
申请日：2000-11-20
申请人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
发明人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
IPC分类号： A61K31/4965 , C07D241/02
CPC分类号： C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
-
10.发明授权Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮公开(公告)号：US06908919B2
公开(公告)日：2005-06-21
申请号：US10195573
申请日：2002-07-15
申请人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
发明人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
IPC分类号： A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/495 , A61P7/02
CPC分类号： C07D401/12 , A61K38/00 , C04B35/632 , C07D241/20 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
-
-
-
-
-
-
-
-
-
搜索结果
281 条记录 (耗时 0.072 秒)
