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1.发明申请Compositions for inducing increased levels of beta-chemokines and methods of use therefor 审中-公开用于诱导β-趋化因子水平升高的组合物及其使用方法公开(公告)号：US20060099170A1
公开(公告)日：2006-05-11
申请号：US10527904
申请日：2003-09-12
IPC分类号： A61K38/19 , A61K38/12 , A61K31/7076 , A61K39/395 , A61K31/551 , A61K31/522 , A61K31/355 , A61K31/19
CPC分类号： A61K31/19 , A61K31/34 , A61K31/355 , A61K31/36 , A61K31/505 , A61K31/522 , A61K31/551 , A61K31/7076
摘要： The present invention relates to compositions and methods for inducing increased levels and availability of β-chemokines by administering to a subject at least one G1 phase arresting compound, wherein the increased levels and availability of β-chemokines block chemokine/viral receptors thereby preventing or treating viral infections.
摘要翻译： 本发明涉及通过向受试者施用至少一种G1期阻滞化合物来诱导增加的β-趋化因子水平和可用性的组合物和方法，其中增加的β-趋化因子的水平和可利用性阻断趋化因子/病毒受体从而预防或治疗 病毒感染。
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2.发明申请Compositions for down-regulation of CCR5 expression and methods of use thereof 失效用于下调CCR5表达的组合物及其使用方法公开(公告)号：US20060154857A1
公开(公告)日：2006-07-13
申请号：US11281195
申请日：2005-11-16
IPC分类号： A61K38/12 , A61K31/522 , A61K31/513 , A61K31/4745 , A61K31/404 , A61K39/42 , A61K31/551
CPC分类号： A61K31/17 , A61K31/33 , A61K31/35 , A61K31/355 , A61K31/385 , A61K31/404 , A61K31/435 , A61K31/513 , A61K31/522 , A61K31/551 , A61K31/70 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
摘要翻译： 本发明涉及通过施用阻止细胞周期的G1期的组合物，从而减少HIV进入T细胞的受体位点，通过操纵活化的淋巴细胞中的细胞周期来下调表面受体CCR5的表达， 艾滋病毒的影响。 此外，公开了包含至少一种G1停滞剂和至少一种抗病毒剂的组合物，其中所述试剂的组合协同地增强抗病毒剂的活性。
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3.发明授权Compositions for down-regulation of CCR5 expression and methods of use thereof 失效用于下调CCR5表达的组合物及其使用方法公开(公告)号：US07863242B2
公开(公告)日：2011-01-04
申请号：US11281195
申请日：2005-11-16
IPC分类号： A61K38/00 , A61K31/445 , A61K31/33
CPC分类号： A61K31/17 , A61K31/33 , A61K31/35 , A61K31/355 , A61K31/385 , A61K31/404 , A61K31/435 , A61K31/513 , A61K31/522 , A61K31/551 , A61K31/70 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
摘要翻译： 本发明涉及通过施用阻止细胞周期的G1期的组合物，从而减少HIV进入T细胞的受体位点，通过操纵活化的淋巴细胞中的细胞周期来下调表面受体CCR5的表达， 艾滋病毒的影响。 此外，公开了包含至少一种G1停滞剂和至少一种抗病毒剂的组合物，其中所述试剂的组合协同地增强抗病毒剂的活性。
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