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1.发明授权
公开(公告)号：US5475091A
公开(公告)日：1995-12-12
申请号：US186457
申请日：1994-01-25
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , G01N33/574
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , C07K14/70525 , C07K16/2821 , C07K16/2845 , G01N33/5743 , A61K39/00 , C07K2317/34 , C07K2317/73 , Y10S530/808 , Y10S530/868
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US5284931A
公开(公告)日：1994-02-08
申请号：US515478
申请日：1990-04-27
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , G01N33/574 , A61K39/395
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , C07K14/70525 , C07K16/2821 , C07K16/2845 , G01N33/5743 , A61K39/00 , C07K2317/34 , C07K2317/73 , Y10S530/808 , Y10S530/868
摘要： Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.
摘要翻译： 包含细胞间粘附分子-1（ICAM-1或CD54）抗体的药物组合物可用于降低与白细胞与携带ICAM-1的细胞粘附相关的炎症严重程度的方法。 用抗ICAM-1抗体治疗降低了与急性器官或组织排斥相关的炎症严重程度和延长的同种异体移植物存活时间。 这样的组合物可以任选地含有其它免疫抑制剂。
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公开(公告)号：US06358510B1
公开(公告)日：2002-03-19
申请号：US08479763
申请日：1995-06-07
IPC分类号： A61K3817
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , A61K39/00 , C07K14/70525 , C07K16/2821 , C07K16/2845 , C07K2317/34 , C07K2317/73 , G01N33/5743 , Y10S530/808 , Y10S530/868 , A61K2300/00
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US5223396A
公开(公告)日：1993-06-29
申请号：US695173
申请日：1991-05-03
申请人： Robert Rothlein , Steven D. Marlin
发明人： Robert Rothlein , Steven D. Marlin
IPC分类号： A61K39/395 , G01N33/53 , G01N33/564 , G01N33/569 , G01N33/577 , G01N33/68
CPC分类号： G01N33/56972 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/245
摘要： A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation. Also contemplated is a method for the detection of organ transplant or tissue graft rejection.
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5.发明授权Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV 失效具有改变LFA-1或HRV结合能力的ICAM-1功能衍生物公开(公告)号：US07354588B1
公开(公告)日：2008-04-08
申请号：US08474388
申请日：1995-06-07
IPC分类号： A61K38/17 , A61K38/16 , C07K14/435 , C07K14/705
CPC分类号： C07K16/2845 , A61K38/00 , A61K39/00 , C07K14/70525 , C07K16/2821 , C07K2317/34 , G01N33/5743
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US5472849A
公开(公告)日：1995-12-05
申请号：US156769
申请日：1993-11-24
申请人： Robert Rothlein , Steven D. Marlin
发明人： Robert Rothlein , Steven D. Marlin
IPC分类号： A61K39/395 , G01N33/53 , G01N33/564 , G01N33/569 , G01N33/577 , G01N33/68 , G01N33/543
CPC分类号： G01N33/56972 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/245
摘要： A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.
摘要翻译： 一种通过测量患者的一种或多种体液的样品中循环细胞间粘附分子（cICAM-1）的量，然后比较患者体内的cICAM-1的量来检测患者中炎症的存在的方法 样品到体液或体液测定的正常值。 可以使用抗ICAM-1抗体测量cICAM-1的量。 高于正常量的cICAM-1表示存在炎症。
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公开(公告)号：US20090035321A1
公开(公告)日：2009-02-05
申请号：US11633078
申请日：2006-12-04
IPC分类号： A61K39/395 , C07K14/47 , C07H21/04 , C07K1/22 , C12Q1/02
CPC分类号： C07K16/2845 , A61K38/00 , A61K39/00 , C07K14/70525 , C07K16/2821 , C07K2317/34 , G01N33/5743
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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8.发明授权Nucleotide sequence encoding intercellular adhesion molecule-1 and fragments thereof 失效编码细胞间粘附分子-1的核苷酸序列及其片段
公开(公告)号：US5612216A
公开(公告)日：1997-03-18
申请号：US186456
申请日：1994-01-25
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , G01N33/574 , C12N1/21 , C12N5/10
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , C07K14/70525 , C07K16/2821 , C07K16/2845 , G01N33/5743 , A61K39/00 , C07K2317/34 , C07K2317/73 , Y10S530/808 , Y10S530/868
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US5354659A
公开(公告)日：1994-10-11
申请号：US964586
申请日：1992-10-21
申请人： Robert Rothlein , Steven D. Marlin
发明人： Robert Rothlein , Steven D. Marlin
IPC分类号： A61K39/395 , G01N33/53 , G01N33/564 , G01N33/569 , G01N33/577 , G01N33/68 , C12Q1/00
CPC分类号： G01N33/56972 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/245
摘要： A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation.
摘要翻译： 一种通过测量患者的一种或多种体液的样品中循环细胞间粘附分子（cICAM-1）的量，然后比较患者体内的cICAM-1的量来检测患者中炎症的存在的方法 样品到体液或体液测定的正常值。 可以使用抗ICAM-1抗体测量cICAM-1的量。 高于正常量的cICAM-1表示存在炎症。
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公开(公告)号：US5831036A
公开(公告)日：1998-11-03
申请号：US140554
申请日：1993-10-25
IPC分类号： C07K16/28 , C07K14/705 , A61K38/17
CPC分类号： C07K16/2845 , C07K16/2821 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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