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公开(公告)号：US07330748B2
公开(公告)日：2008-02-12
申请号：US10948942
申请日：2004-09-24
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing CEDST MRI analysis of the subject, and comparing the results to known in vitro results to determine metabolite concentration.
摘要翻译： 用于确定代谢物的体内浓度的方法，其包括对受试者施用造影剂，允许造影剂分散到感兴趣的组织，进行受试者的CEDST MRI分析，并将结果与已知的体外结果进行比较以确定代谢物 浓度。
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公开(公告)号：US20080167549A1
公开(公告)日：2008-07-10
申请号：US12002553
申请日：2007-12-17
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contrast agents can be used to practice the present method including, without limitation, sugars, amino acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.
摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 可以使用许多不同的造影剂来实施本发明的方法，包括但不限于糖，氨基酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。
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公开(公告)号：US06963769B1
公开(公告)日：2005-11-08
申请号：US09959138
申请日：2000-04-20
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.
摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 许多不同的耐受剂可用于实施本发明的方法，包括但不限于糖，阿莫西酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。
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