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公开(公告)号：US07330748B2
公开(公告)日：2008-02-12
申请号：US10948942
申请日：2004-09-24
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing CEDST MRI analysis of the subject, and comparing the results to known in vitro results to determine metabolite concentration.
摘要翻译： 用于确定代谢物的体内浓度的方法，其包括对受试者施用造影剂，允许造影剂分散到感兴趣的组织，进行受试者的CEDST MRI分析，并将结果与已知的体外结果进行比较以确定代谢物 浓度。
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公开(公告)号：US20080167549A1
公开(公告)日：2008-07-10
申请号：US12002553
申请日：2007-12-17
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contrast agents can be used to practice the present method including, without limitation, sugars, amino acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.
摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 可以使用许多不同的造影剂来实施本发明的方法，包括但不限于糖，氨基酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。
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公开(公告)号：US06963769B1
公开(公告)日：2005-11-08
申请号：US09959138
申请日：2000-04-20
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.
摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 许多不同的耐受剂可用于实施本发明的方法，包括但不限于糖，阿莫西酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。
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公开(公告)号：US07667210B2
公开(公告)日：2010-02-23
申请号：US11979600
申请日：2007-11-06
IPC分类号： G01J1/58
CPC分类号： G02B21/06 , G02B2207/114
摘要： A multi-photon microscope has an illumination source, an objective lens unit arranged in an optical path of the illumination source, a first light collection system arranged to collect a first portion of light emitted from a sample when the sample is illuminated by light from the illumination source, and a second light collection system arranged to collect a second portion of light emitted from the sample when the sample is illuminated by light from the illumination source. The first portion of light when collected by the first light collection system and the second portion of light when collected by the second light collection system, together provide a means of collecting as much light from as many angles as possible emanating from an emitting point source. This collection scheme has the potential to approach the total emission collection of light from an emitting point source depending on the optical properties of the sample being imaged.
摘要翻译： 多光子显微镜具有照明源，布置在照明源的光路中的物镜单元，第一光收集系统，被布置成当样品被来自光源的光照射时，收集从样品发射的光的第一部分 照明源和第二光收集系统，其被布置成当样品被来自照明源的光照射时收集从样品发射的光的第二部分。 由第一光收集系统收集的第一部分光和第二光收集系统收集的第二部分光一起提供了从发射点源发出的尽可能多的角度收集尽可能多的光的装置。 该采集方案具有取决于正在成像的样品的光学性质来接近来自发射点源的光的总发射收集的潜力。
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5.发明授权Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging 失效磁化转移对比度和质子松弛及其在磁共振成像中的应用
公开(公告)号：US5050609A
公开(公告)日：1991-09-24
申请号：US337980
申请日：1989-04-14
申请人： Robert S. Balaban , Steven D. Wolff
发明人： Robert S. Balaban , Steven D. Wolff
IPC分类号： G01R33/28 , G01R33/483 , G01R33/563
CPC分类号： G01R33/5605 , G01R33/4833
摘要： A nuclear magnetic resonance method is provided for monitoring and imaging the exchange of magnetization between protons in free water and protons in a relatively immobilized pool of protons in a sample. The method provides a new form of contrast for nuclear magnetic resonance imaging of samples such as biological tissues, polymers, and geological samples.
摘要翻译： 提供了核磁共振方法，用于监测和成像样品中质子相对固定的质子池中游离水质子与质子之间的磁化交换。 该方法为生物组织，聚合物和地质样品等样品的核磁共振成像提供了新的对比形式。
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公开(公告)号：US06645144B1
公开(公告)日：2003-11-11
申请号：US09807730
申请日：2001-05-18
申请人： Han Wen , Robert S. Balaban
发明人： Han Wen , Robert S. Balaban
IPC分类号： A61B800
CPC分类号： G01N29/0654 , A61B8/00 , G01N29/0609 , G01N29/09 , G01N29/221 , G01N29/225 , G01N29/2431 , G01N2291/02475 , G01N2291/02483 , G01N2291/0421 , G01N2291/0422 , G01N2291/044
摘要： Methods are disclosed for obtaining electroacoustic images of specimens. One method includes applying an acoustic wave to a specimen and forming an image based on an electroacoustically induced electric field or voltage. In another method, an electric field or voltage is applied to a specimen and an electroacoustically induced acoustic wave is measured to form an image. Apparatus suitable for obtaining electroacoustc images are disclosed as well as methods for distinguishing image contributions from the electroacoustic, thermoacoustic, and Hall effects.
摘要翻译： 公开了用于获得样品的电声图像的方法。 一种方法包括将声波施加到样本并基于电声感应电场或电压形成图像。 在另一种方法中，将电场或电压施加到样本，并且测量电声感应声波以形成图像。 公开了适用于获得电声图像的装置以及用于区别图像贡献与电声，热声和霍尔效应的方法。
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7.发明授权Local magnetization spoiling using a gradient insert for reducing the field of view in magnetic resonance imaging 有权使用梯度插入件进行局部磁化破坏，以减少磁共振成像中的视场公开(公告)号：US06384601B1
公开(公告)日：2002-05-07
申请号：US09403530
申请日：1999-10-19
申请人： David G. Wiesler , Han Wen , Robert S. Balaban , Steven D. Wolff
发明人： David G. Wiesler , Han Wen , Robert S. Balaban , Steven D. Wolff
IPC分类号： G01V300
CPC分类号： G01R33/4838
摘要： A method, and related apparatus, for suppressing the magnetic resonance signal to an experimentally adjustable depth by applying a spatially inhomogeneous field between the slice-select pulse and the data acquisition. Eliminating the signal from near surface regions allows one to shrink the field of view of an image without introducing aliasing artifacts, thereby improving the image's resolution or decreasing imaging time. Experimental tests on a phantom and a human subject indicate that the depth of signal suppression may be continuously varied to depths of over 80 millimeters with modest requirements on power supplies, pulse sequences, and materials.
摘要翻译： 一种通过在切片选择脉冲和数据采集之间施加空间不均匀场来将磁共振信号抑制到实验可调深度的方法和相关装置。 消除来自近表面区域的信号允许缩小图像的视野而不引入混叠伪像，从而改善图像的分辨率或降低成像时间。 对幻影和人类受试者进行的实验测试表明，信号的抑制深度可以连续地变化到超过80毫米的深度，对电源，脉冲序列和材料的要求不高。
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8.发明授权Non-contact total emission detection method and system for multi-photon microscopy 有权非接触式全发射检测方法及多光子显微镜系统公开(公告)号：US08759792B2
公开(公告)日：2014-06-24
申请号：US13383248
申请日：2010-07-12
IPC分类号： H01J65/08
CPC分类号： G01N21/64 , G01N21/6458 , G02B21/02 , G02B21/084 , G02B21/16 , G02B2207/113 , G02B2207/114
摘要： A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected.
摘要翻译： 公开了一种多光子显微镜，其具有将照明光透射到具有用于照亮设置在壳体外部的样本的物镜结构的壳体中并将从样本发射的发射光的第一部分引导到检测系统的照明光源。 光收集系统设置在物镜布置附近，用于将发射光的第二部分以与发射光的第一部分同轴的关系引导到检测系统，使得基本上所有的照射区域周围和上方的发射光 被检测到。
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9.发明授权MRI coil using inductively coupled individually tuned elements arranged as free-pivoting components 失效MRI线圈使用电感耦合单独调谐的元件作为自由转动元件
公开(公告)号：US5483163A
公开(公告)日：1996-01-09
申请号：US104849
申请日：1993-08-12
申请人： Han Wen , Andrew S. Chesnick , Robert S. Balaban
发明人： Han Wen , Andrew S. Chesnick , Robert S. Balaban
CPC分类号： G01R33/3453 , G01R33/3628 , G01R33/34007 , G01R33/3642
摘要： An MRI probe/transmitter coil has a pair of concentric cylinders with a plurality of inductively coupled freely rotating resonant elements radially mounted between the two cylinders. The coil can be tuned both symmetrically by pivoting all the resonant elements uniformly or asymmetrically by tuning them individually. The coil is driven in quadrature by a quad-hybrid circuit. A substantial part of the electromagnetic energy is stored in the resonant elements outside of the loading region of the coil to reduce perturbation in the coil operation due to the characteristics of the test subject.
摘要翻译： MRI探针/发射器线圈具有一对同心圆筒，其具有径向安装在两个气缸之间的多个感应耦合的自由旋转的谐振元件。 可以通过单独调谐来均匀或不对称地枢转所有谐振元件来对称地调节线圈。 线圈由四态混合电路正交驱动。 电磁能的大部分被存储在线圈负载区域之外的谐振元件中，以减少由于测试对象的特性引起的线圈操作的扰动。
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10.发明授权公开(公告)号：US09448158B2
公开(公告)日：2016-09-20
申请号：US13983534
申请日：2012-02-03
CPC分类号： G01N21/01 , G01N21/6458 , G01N2021/6469 , G01N2201/08 , G02B6/241 , G02B21/16 , G02B21/26
摘要： Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide.
摘要翻译： 用于荧光显微镜的收集器包括具有样本体积的板状光导，例如准确地保持样本的样本。 样本体积由平板导光体的表面限制，允许横向传播的荧光进入平板光导并向检测或成像系统传播。 通常，平板导光体具有椭圆周长，并且样品体积位于椭圆周长的第一焦点。 诸如锥形反射器的反射器位于第二焦点处，以便引导所收集的荧光以离开平板光导。
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