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1.发明授权公开(公告)号：US08290595B2
公开(公告)日：2012-10-16
申请号：US11482264
申请日：2006-07-07
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/08 , A61N1/36117
摘要： Devices and methods for controlling the low-pressure baroreflex system for the treatment and/or management of cardiovascular, renal, and neurological disorders.
摘要翻译： 用于控制用于治疗和/或治疗心血管，肾脏和神经障碍的低压压力反射系统的装置和方法。
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公开(公告)号：US09044609B2
公开(公告)日：2015-06-02
申请号：US13300232
申请日：2011-11-18
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
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公开(公告)号：US20100249874A1
公开(公告)日：2010-09-30
申请号：US12785287
申请日：2010-05-21
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/36
CPC分类号： A61N1/0556 , A61N1/36114 , A61N1/36117
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压力感受器激活装置可以利用电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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公开(公告)号：US20100179614A1
公开(公告)日：2010-07-15
申请号：US12719696
申请日：2010-03-08
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. An intravascularly implantable medical device may include a sleeve formed at least in part of an expandable member configured to be movably attachable about at least a portion of an outer surface of an expandable intravascular stent, and one or more electrodes disposed on the sleeve and coupled to a control system and configured to selectively activate baroreceptors within a wall of a vessel when the expandable intravascular stent is implanted within the vessel.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 血管内可植入医疗装置可以包括至少部分可扩张构件形成的套筒，所述可扩张构件构造成围绕可膨胀血管内支架的外表面的至少一部分可移动地附接，以及一个或多个设置在套筒上并连接到 控制系统，并且被配置为当可扩张血管内支架植入血管内时选择性地激活血管壁内的压力感受器。
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5.发明申请DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 有权用于通过耦合电极进行心脏血管反射控制的装置和方法公开(公告)号：US20100174347A1
公开(公告)日：2010-07-08
申请号：US12616057
申请日：2009-11-10
IPC分类号： A61N1/05
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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6.发明授权Electrode structures and methods for their use in cardiovascular reflex control 有权用于心血管反射控制的电极结构和方法公开(公告)号：US07499742B2
公开(公告)日：2009-03-03
申请号：US10402911
申请日：2003-03-27
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压力感受器激活装置可以利用电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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公开(公告)号：US20080171923A1
公开(公告)日：2008-07-17
申请号：US11933302
申请日：2007-10-31
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61B5/00
CPC分类号： A61N1/3686 , A61N1/05 , A61N1/08 , A61N1/36117 , A61N1/36185
摘要： An apparatus capable of being implanted in a patient's body, including a posture sensor, a heart rate sensor, and a processor coupled to the posture sensor and the heart rate sensor. The processor is configured to measure the patient's heart rate via the cardiac signal sensor, detect a change in a posture of the patient's body via the posture sensor, and determine an autonomic tone of the patient's body based on the patient's heart rate measured during a time period corresponding to the change in posture.
摘要翻译： 一种能够植入患者体内的装置，包括姿势传感器，心率传感器和耦合到姿势传感器和心率传感器的处理器。 处理器被配置为经由心脏信号传感器测量患者的心率，通过姿态传感器检测患者身体姿势的变化，并且基于在一段时间内测量的患者心率来确定患者身体的自主音调 对应于姿势变化的时期。
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公开(公告)号：US06850801B2
公开(公告)日：2005-02-01
申请号：US09963991
申请日：2001-09-26
IPC分类号： A61N1/08
CPC分类号： A61N1/36117
摘要： Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. A mapping method permits the baroreceptor activation device to be precisely located to maximize therapeutic efficacy.
摘要翻译： 通过激活压力感受器可以选择性地和可控地降低血压，神经系统活性和神经激素活性的装置，系统和方法。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦内。 映射方法允许压力感受器激活装置精确定位以最大化治疗功效。
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9.发明授权Devices and methods for cardiovascular reflex control via coupled electrodes 有权通过耦合电极进行心血管反射控制的装置和方法公开(公告)号：US07616997B2
公开(公告)日：2009-11-10
申请号：US10402393
申请日：2003-03-27
IPC分类号： A61N1/18
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义促进长期疗效并降低功率需求/消耗的刺激方案的算法。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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10.发明申请DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 审中-公开用于通过耦合电极进行心脏血管反射控制的装置和方法公开(公告)号：US20090234418A1
公开(公告)日：2009-09-17
申请号：US12421416
申请日：2009-04-09
IPC分类号： A61N1/36
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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