公开(公告)号：US20060105985A1

公开(公告)日：2006-05-18

申请号：US11318677

申请日：2005-12-27

申请人： Robert Shalwitz ,  Tapas Das ,  Paul Johns ,  James Leach

发明人： Robert Shalwitz ,  Tapas Das ,  Paul Johns ,  James Leach

IPC分类号： A61K31/7076 ,  A61K31/7072

CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708

摘要： Disclosed are compositions and methods for alleviating mucositis, wherein said methods and compositions are directed to the formulation or use of selected nucleoside derivatives, especially ADP-ribose, that conform to the general formula A-B-X and pharmaceutically acceptable salts thereof, wherein “A” is a nucleoside structure selected from adenosine, guanosine, and uridine; “B” is a diphosphate linkage attached to the 5′ carbon of the nucleoside ribose moiety; and “X” is attached to B an is a moiety selected from hydrogen, furanose, or pyranose. Also disclosed are pharmaceuticals and nutritional liquid embodiments thereof, including lozenges, mouthwashes, or other product forms that effectively coat the oral, laryngeal or other mucosal areas. It has been found that these compositions and methods effectively alleviate mucositis in susceptible individuals, especially when administered prior to, during, or after treatments commonly associated with the development of mucositis such as certain chemotherapies, radiation therapies, or combinations thereof.

公开(公告)号：US20080081796A1

公开(公告)日：2008-04-03

申请号：US11931613

申请日：2007-10-31

申请人： Robert Shalwitz ,  Tapas Das ,  Paul Johns ,  James Leach

发明人： Robert Shalwitz ,  Tapas Das ,  Paul Johns ,  James Leach

IPC分类号： A61K31/7072 ,  A61K31/7076 ,  A61P1/04

CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708

摘要： Disclosed are compositions and methods for alleviating mucositis, wherein said methods and compositions are directed to the formulation or use of selected nucleoside derivatives, especially ADP-ribose, that conform to the general formula A-B-X and pharmaceutically acceptable salts thereof, wherein “A” is a nucleoside structure selected from adenosine, guanosine, and uridine; “B” is a diphosphate linkage attached to the 5′ carbon of the nucleoside ribose moiety; and “X” is attached to B an is a moiety selected from hydrogen, furanose, or pyranose. Also disclosed are pharmaceuticals and nutritional liquid embodiments thereof, including lozenges, mouthwashes, or other product forms that effectively coat the oral, laryngeal or other mucosal areas. It has been found that these compositions and methods effectively alleviate mucositis in susceptible individuals, especially when administered prior to, during, or after treatments commonly associated with the development of mucositis such as certain chemotherapies, radiation therapies, or combinations thereof.

摘要翻译： 公开了用于缓解粘膜炎的组合物和方法，其中所述方法和组合物涉及配制或使用符合通式ABX及其药学上可接受的盐的选定的核苷衍生物，特别是ADP-核糖，其中“A”是 选自腺苷，鸟苷和尿苷的核苷结构; “B”是连接到核苷核糖部分的5'碳上的二磷酸键; 和“X”连接于B an是选自氢，呋喃糖或吡喃糖的部分。 还公开了其药物和营养液体实施方案，包括有效地涂覆口腔，喉部或其他粘膜区域的锭剂，漱口剂或其它产品形式。 已经发现，这些组合物和方法有效地缓解易感个体中的粘膜炎，特别是在通常与粘膜炎发展相关的治疗之前，期间或之后施用，例如某些化学疗法，放射疗法或其组合时。

公开(公告)号：US20130139071A1

公开(公告)日：2013-05-30

申请号：US13304371

申请日：2011-11-24

申请人： Aaron Hoff ,  Kori Inkpen Quinn ,  Paul Johns ,  Asta Roseway ,  Chen Zhao ,  Xiang Cao ,  Jennifer Marlow ,  John C. Tang

发明人： Aaron Hoff ,  Kori Inkpen Quinn ,  Paul Johns ,  Asta Roseway ,  Chen Zhao ,  Xiang Cao ,  Jennifer Marlow ,  John C. Tang

IPC分类号： G06F3/00

CPC分类号： G06Q10/1095 ,  G06F17/30 ,  G06F17/30056 ,  G06F17/30058 ,  G06F17/30598 ,  H04L65/403 ,  H04L67/28

摘要： Embodiments described herein relate to enabling a lightweight way of recording and sharing video messages intended to provide input to a future meeting that cannot be personally attended. A person who cannot attend the meeting pre-records their thoughts and remarks for the meeting as video clips for presentation at the meeting. A physical device with at least a display is presented at the meeting. The physically present participants can play the pre-recorded clips on the device. Video of participants' responses to the clips is recorded and made available so that the represented attendee can view the participants' responses.

摘要翻译： 本文描述的实施例涉及实现轻量级的记录和共享视频消息的方式，该视频消息旨在向未来的会议提供不能被亲自参与的输入。 不能出席会议的人将会议的思想和言论预先记录在会议的视频剪辑中。 在会议上提供了至少具有显示屏的物理设备。 身体上的参与者可以在设备上播放预先录制的剪辑。 记录参与者对剪辑的响应的视频被记录并提供，以便代表参加者可以查看参与者的响应。

公开(公告)号：US20110301958A1

公开(公告)日：2011-12-08

申请号：US12794068

申请日：2010-06-04

申请人： Alice Jane Bernheim Brush ,  Paul Johns ,  Jen Anderson ,  Connie Missimer ,  Seung Yang ,  Jean Ku

发明人： Alice Jane Bernheim Brush ,  Paul Johns ,  Jen Anderson ,  Connie Missimer ,  Seung Yang ,  Jean Ku

IPC分类号： G10L21/00

CPC分类号： G10L15/22 ,  G06F9/451

摘要： Whenever an event occurs on a computing system which will accept a response from a user of the system, the system automatically determines whether or not to enable speech interaction with the system for the event response. Whenever speech interaction is enabled with the system for the event response, the system provides a notification to the user which informs the user of the event and their options for responding thereto, where these options include responding verbally. Whenever the user responds within a prescribed period of time via a voice command (VC), the system attempts to recognize the VC. Whenever the VC is successfully recognized, the system responds appropriately to the VC.

摘要翻译： 每当事件发生在将接受来自系统的用户的响应的计算系统时，系统自动地确定是否允许与系统进行语音交互以用于事件响应。 无论何时当系统为事件响应启用语音交互时，系统向用户提供通知用户事件及其响应选项，其中这些选项包括口头回应。 无论何时用户通过语音命令（VC）在规定的时间内作出响应，系统会尝试识别VC。 每当VC被成功识别时，系统将对VC进行适当的响应。

公开(公告)号：US08635293B2

公开(公告)日：2014-01-21

申请号：US13159201

申请日：2011-06-13

申请人： Danyel Fisher ,  Aaron Hoff ,  Mary Czerwinski ,  Kori Inkpen Quinn ,  Jeremy Barksdale ,  Paul Johns ,  Asta Roseway ,  Gina Venolia ,  John Tang

发明人： Danyel Fisher ,  Aaron Hoff ,  Mary Czerwinski ,  Kori Inkpen Quinn ,  Jeremy Barksdale ,  Paul Johns ,  Asta Roseway ,  Gina Venolia ,  John Tang

IPC分类号： G06F15/16

CPC分类号： G06Q10/107 ,  H04L51/16

摘要： Described are systems and user interfaces for facilitating asynchronous communication with video threads. Implementations may enable members of a team to have threaded view of video messages, from which they can capture video, record their screen, and send, receive, and reply to a video message. The screen recording feature enables team members to share parts of their screen while simultaneously narrating, if desired. Video messages are threaded by topic and each conversation is visually represented.

摘要翻译： 描述了用于促进与视频线程的异步通信的系统和用户界面。 实现可以使团队成员具有视频消息的线程视图，从中可以捕获视频，记录他们的屏幕，以及发送，接收和回复视频消息。 如果需要，屏幕录制功能使团队成员能够共享屏幕的一部分，同时进行叙述。 视频消息按主题进行了线索，每个会话都被视觉表示。

公开(公告)号：US08600763B2

公开(公告)日：2013-12-03

申请号：US12794068

申请日：2010-06-04

申请人： Alice Jane Bernheim Brush ,  Paul Johns ,  Jen Anderson ,  Connie Missimer ,  Seung Yang ,  Jean Ku

发明人： Alice Jane Bernheim Brush ,  Paul Johns ,  Jen Anderson ,  Connie Missimer ,  Seung Yang ,  Jean Ku

IPC分类号： G10L21/00

CPC分类号： G10L15/22 ,  G06F9/451

摘要： Whenever an event occurs on a computing system which will accept a response from a user of the system, the system automatically determines whether or not to enable speech interaction with the system for the event response. Whenever speech interaction is enabled with the system for the event response, the system provides a notification to the user which informs the user of the event and their options for responding thereto, where these options include responding verbally. Whenever the user responds within a prescribed period of time via a voice command (VC), the system attempts to recognize the VC. Whenever the VC is successfully recognized, the system responds appropriately to the VC.

摘要翻译： 每当事件发生在将接受来自系统的用户的响应的计算系统时，系统自动地确定是否启用与系统的语音交互以用于事件响应。 无论何时当系统为事件响应启用语音交互时，系统向用户提供通知用户事件及其响应选项，其中这些选项包括口头回应。 无论何时用户通过语音命令（VC）在规定的时间内作出响应，系统会尝试识别VC。 每当VC被成功识别时，系统将对VC进行适当的响应。

公开(公告)号：US20070141124A1

公开(公告)日：2007-06-21

申请号：US11642033

申请日：2006-12-19

申请人： Paul Johns ,  Chron-Si Lai

发明人： Paul Johns ,  Chron-Si Lai

IPC分类号： A61K47/00

CPC分类号： A23G4/20 ,  A23L29/10 ,  A23L29/20 ,  A23L29/231 ,  A23L29/256 ,  A23L29/27 ,  A23L29/272 ,  A23L33/17 ,  A23L33/40 ,  A61K9/107

摘要： Disclosed are induced viscosity nutritional emulsions comprising (A) protein having a protein-bound methionine sulfoxide content of 8% or less of the total protein-bound methionine, on a molar basis, (B) fat, and (C) an induced viscosity fiber system that provides the emulsion with a packaged viscosity of less than 300 cps and an induced viscosity following consumption of at least 300 cps, wherein the induced viscosity nutritional emulsion is an oil-in-water emulsion. It has been found that product stability is improved and shelf-life increased by selection of those protein sources having a low methionine sulfoxide content.

摘要翻译： 公开了诱导粘度营养乳液，其包含（A）蛋白质结合的甲硫氨酸亚砜含量为总蛋白质结合的甲硫氨酸的8％或更低（基于摩尔）的蛋白质（B）脂肪，和（C）诱导粘度纤维 系统，其提供具有小于300cps的包装粘度和消耗至少300cps的诱导粘度的乳液，其中诱导粘度营养乳液是水包油乳液。 已经发现，通过选择具有低甲硫氨酸亚砜含量的那些蛋白质源，产物稳定性提高并且保质期增加。

公开(公告)号：US09471902B2

公开(公告)日：2016-10-18

申请号：US13304371

申请日：2011-11-24

申请人： Aaron Hoff ,  Kori Inkpen Quinn ,  Paul Johns ,  Asta Roseway ,  Chen Zhao ,  Xiang Cao ,  Jennifer Marlow ,  John C. Tang

发明人： Aaron Hoff ,  Kori Inkpen Quinn ,  Paul Johns ,  Asta Roseway ,  Chen Zhao ,  Xiang Cao ,  Jennifer Marlow ,  John C. Tang

IPC分类号： G06F3/048 ,  G06Q10/10 ,  G06F17/30

CPC分类号： G06Q10/1095 ,  G06F17/30 ,  G06F17/30056 ,  G06F17/30058 ,  G06F17/30598 ,  H04L65/403 ,  H04L67/28

摘要： Embodiments described herein relate to enabling a lightweight way of recording and sharing video messages intended to provide input to a future meeting that cannot be personally attended. A person who cannot attend the meeting pre-records their thoughts and remarks for the meeting as video clips for presentation at the meeting. A physical device with at least a display is presented at the meeting. The physically present participants can play the pre-recorded clips on the device. Video of participants' responses to the clips is recorded and made available so that the represented attendee can view the participants' responses.

摘要翻译： 本文描述的实施例涉及实现轻量级的记录和共享视频消息的方式，该视频消息旨在向未来的会议提供不能被亲自参与的输入。 不能出席会议的人将会议的思想和言论预先记录在会议的视频剪辑中。 在会议上提供了至少具有显示屏的物理设备。 身体上的参与者可以在设备上播放预先录制的剪辑。 记录参与者对剪辑的响应的视频被记录并提供，以便代表参加者可以查看参与者的响应。

公开(公告)号：US20120317210A1

公开(公告)日：2012-12-13

申请号：US13159201

申请日：2011-06-13

申请人： Danyel Fisher ,  Aaron Hoff ,  Mary Czerwinski ,  Kori Inkpen Quinn ,  Jeremy Barksdale ,  Paul Johns ,  Asta Roseway ,  Gina Venolia ,  John C. Tang

发明人： Danyel Fisher ,  Aaron Hoff ,  Mary Czerwinski ,  Kori Inkpen Quinn ,  Jeremy Barksdale ,  Paul Johns ,  Asta Roseway ,  Gina Venolia ,  John C. Tang

IPC分类号： G06F15/16

CPC分类号： G06Q10/107 ,  H04L51/16

摘要： Described are systems and user interfaces for facilitating asynchronous communication with video threads. Implementations may enable members of a team to have threaded view of video messages, from which they can capture video, record their screen, and send, receive, and reply to a video message. The screen recording feature enables team members to share parts of their screen while simultaneously narrating, if desired. Video messages are threaded by topic and each conversation is visually represented.

摘要翻译： 描述了用于促进与视频线程的异步通信的系统和用户界面。 实现可以使团队成员具有视频消息的线程视图，从中可以捕获视频，记录他们的屏幕，以及发送，接收和回复视频消息。 如果需要，屏幕录制功能使团队成员能够共享屏幕的一部分，同时进行叙述。 视频消息按主题进行了线索，每个会话都被视觉表示。

公开(公告)号：US20070281055A1

公开(公告)日：2007-12-06

申请号：US11756844

申请日：2007-06-01

申请人： Gaurav Patel ,  Paul Johns ,  Susan Fawcett ,  Robert Joseph ,  Louis Ndife ,  Rosalyn Phillips ,  Eric Himmelreich

发明人： Gaurav Patel ,  Paul Johns ,  Susan Fawcett ,  Robert Joseph ,  Louis Ndife ,  Rosalyn Phillips ,  Eric Himmelreich

IPC分类号： A23L1/30

CPC分类号： A23J3/10 ,  A23J3/08 ,  A23J3/16 ,  A23L33/185 ,  A23L33/19

摘要： Disclosed are food products comprising a clean milk protein and/or other clean protein ingredients, and one or more other food ingredients, wherein the food product has a concentration of off-note contaminant markers (OCM) per kg of milk protein of 1100 μg or less, and/or a concentration of off-note contaminant markers (OCM) per kg of soy protein of 1001 mg or less. Also disclosed is a water washing method for producing clean milk protein that may be used in food products.

摘要翻译： 本发明公开了包含清洁乳蛋白质和/或其它清洁蛋白成分的食品，以及一种或多种其它食品成分，其中该食品具有每千克1100克奶粉蛋白浓度的非标记污染标记物（OCM）或 和/或浓度为0.001mg或更少的每公斤大豆蛋白的非标记杂质标记物（OCM）浓度。 还公开了用于生产可用于食品中的清洁乳蛋白质的水洗方法。