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    Methods and compositions for oral delivery of Areca and mate' or theobromine
    2.
    发明授权
    Methods and compositions for oral delivery of Areca and mate' or theobromine 失效
    口服阿尔卡和配伍或可可碱的方法和组合物

    公开(公告)号：US07291352B2

    公开(公告)日：2007-11-06

    申请号：US10945378

    申请日：2004-09-20

    申请人： Robert T. Gow ,  John Pierce ,  George W. Sypert

    发明人： Robert T. Gow ,  John Pierce ,  George W. Sypert

    IPC分类号： A61K36/00 ,  A61K36/889 ,  A61K31/44

    CPC分类号： C07D407/06 ,  A61K31/366 ,  A61K36/185 ,  A61K36/889 ,  A61K45/06 ,  C07D309/32 ,  C07D309/38 ,  C07D309/40 ,  Y02A50/473 ,  A61K2300/00

    摘要： The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and maté extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.

    摘要翻译： 本发明包括方法和组合物，其包含阿尔卡提取物组合物和包含白藜芦醇或可可碱的提取物的组合物。 本发明的方法包括制备包含槟榔芹提取物组合物和美味提取物组合物或可可碱的药物或营养产品的方法，以及使用提取产物和药物和营养产品的方法。 本发明还包括治疗与精神和身体疲劳和肥胖有关的病症的方法，以及提高精神焦虑，认知和感觉，包括施用本发明的组合物。

    Methods and compositions comprising ilex
    3.
    发明授权
    Methods and compositions comprising ilex 失效
    包含ilex的方法和组合物

    公开(公告)号：US07294353B2

    公开(公告)日：2007-11-13

    申请号：US10970017

    申请日：2004-10-21

    申请人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

    发明人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

    IPC分类号： A61K36/00

    CPC分类号： A61K36/185

    摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

    摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

    Methods and compositions comprising Ilex
    4.
    发明授权
    Methods and compositions comprising Ilex 失效
    包含Ilex的方法和组合物

    公开(公告)号：US07279184B2

    公开(公告)日：2007-10-09

    申请号：US10972986

    申请日：2004-10-25

    申请人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

    发明人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

    IPC分类号： A61K36/00

    CPC分类号： A61K36/185

    摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

    摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

    Compositions and Methods Comprising Zingiber Species
    7.
    发明申请
    Compositions and Methods Comprising Zingiber Species 审中-公开
    组合和方法包括兴宁种

    公开(公告)号：US20080160116A1

    公开(公告)日：2008-07-03

    申请号：US11951948

    申请日：2007-12-06

    申请人： Dan Li ,  George W. Sypert ,  Robert T. Gow

    发明人： Dan Li ,  George W. Sypert ,  Robert T. Gow

    IPC分类号： A61K36/906 ,  A61K31/715 ,  A61K31/12 ,  A61P43/00

    CPC分类号： A61K36/9068 ,  A61K31/12 ,  A61K31/715

    摘要： An aspect of the present invention relates to compositions comprising a gingerol, for example, compositions comprising gingerol in an amount greater than about 2% by weight. In some aspects of the invention, the composition comprises 6-gingerol, 8-gingerol, 10-gingerol, 6-shagaol, or combinations thereof. Another aspect of the invention relates to a method for extracting a ginger species comprising, sequentially extracting a ginger species plant material to yield an essential oil fraction, a gingerol fraction, a phenolic fraction, and a polysaccharide fraction, wherein the essential oil and gingerol fractions are derived by extracting plant feedstock material by supercritical carbon dioxide extraction, the phenolic fraction is extracted from the plant feedstock material or from the remainder of the essential oil and gingerol extractions by hydroalcoholic extraction, and the polysaccharide fraction is derived by water extraction of the remainder of the phenolic extraction.

    摘要翻译： 本发明的一个方面涉及包含姜醇的组合物，例如包含量大于约2重量％的姜酚的组合物。 在本发明的某些方面，该组合物包含6-姜醇，8-姜醇，10-姜醇，6-莽草醇或其组合。 本发明的另一方面涉及一种用于提取生姜物种的方法，包括：依次提取姜种植物材料以产生精油​​馏分，姜油醇馏分，酚馏分和多糖级分，其中所述精油和姜醇馏分 通过超临界二氧化碳提取提取植物原料，通过水醇提取从植物原料或其余的精油和姜油中提取酚类成分，多糖级分是通过水提取其余部分得到的 的酚提取。