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公开(公告)号：US20070066607A1
公开(公告)日：2007-03-22
申请号：US10552023
申请日：2004-04-02
申请人： Robin Fairhurst , David Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil Taylor , Roger Taylor , Katharine Turner , Simon Watson
发明人： Robin Fairhurst , David Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil Taylor , Roger Taylor , Katharine Turner , Simon Watson
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/538 , A61K31/496 , A61K31/4709 , C07D265/36 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula I free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 式I的游离或盐形式的化合物，其中-CY-，R 1和R 2是G具有说明书中指出的含义，可用于治疗 通过β2 - 肾上腺素受体的激活而被预防或缓解。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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公开(公告)号：US07745462B2
公开(公告)日：2010-06-29
申请号：US10552023
申请日：2004-04-02
申请人： Robin Alec Fairhurst , David Andrew Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil John Press , Roger John Taylor , Katharine Louise Turner , Simon James Watson
发明人： Robin Alec Fairhurst , David Andrew Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil John Press , Roger John Taylor , Katharine Louise Turner , Simon James Watson
IPC分类号： A61K31/02 , C07D215/38
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula I in free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中-C-Y-，R 1和R 2为G具有本说明书中指出的含义，可用于治疗通过活化2-肾上腺素受体而预防或缓解的病症 。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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3.发明申请Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity 审中-公开具有β-2-肾上腺素受体激动剂活性的苯并噻唑衍生物公开(公告)号：US20060106075A1
公开(公告)日：2006-05-18
申请号：US10522359
申请日：2003-08-08
申请人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
发明人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
IPC分类号： A61K31/428 , C07D277/68
CPC分类号： C07D417/12 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D277/68
摘要： Compounds of formula (I) in free or salt or solvate form, wherein X has the meaning indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中X具有说明书中指出的含义，可用于治疗通过β2 - 肾上腺素受体激活而预防或缓解的病症。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20050153957A1
公开(公告)日：2005-07-14
申请号：US11074400
申请日：2005-03-07
申请人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
IPC分类号： A61K31/137 , A61K31/167 , A61K31/18 , A61K31/222 , A61K31/4704 , A61P11/00 , A61P11/02 , A61P15/06 , A61P25/02 , A61P37/00 , A61P37/08 , A61P43/00 , C07C211/38 , C07C211/42 , C07C215/76 , C07C215/80 , C07C233/03 , C07C233/43 , C07C311/03 , C07C311/08 , C07D215/22 , C07D215/227 , C07D215/26 , C07D405/12 , A61K31/542 , A61K31/423 , A61K31/428 , A61K31/4706 , A61K31/538
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 游离或盐或溶剂合物形式的化合物，其中Ar是式Y基团是碳或氮，R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， R 0，R 9，R 10，X，n，p，q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是 治疗阻塞性或炎症性气道疾病。
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5.发明申请Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity 审中-公开具有β-2-肾上腺素受体激动剂活性的苯并噻唑衍生物公开(公告)号：US20070249586A1
公开(公告)日：2007-10-25
申请号：US11823622
申请日：2007-06-27
申请人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
发明人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
IPC分类号： A61K31/428 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/55 , C07D417/02
CPC分类号： C07D417/12 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D277/68
摘要： Compounds of formula (I) in free or salt or solvate form, wherein X has the meaning indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中X具有说明书中指出的含义，可用于治疗通过β2 - 肾上腺素受体激活而预防或缓解的病症。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US08436017B2
公开(公告)日：2013-05-07
申请号：US13555536
申请日：2012-07-23
IPC分类号： A61K31/395 , A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20140343091A1
公开(公告)日：2014-11-20
申请号：US14450692
申请日：2014-08-04
IPC分类号： A61K31/4709 , A61K45/06
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, whereAr is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US08658673B2
公开(公告)日：2014-02-25
申请号：US13858308
申请日：2013-04-08
IPC分类号： A61K31/395 , A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20130231367A1
公开(公告)日：2013-09-05
申请号：US13858308
申请日：2013-04-08
IPC分类号： C07D215/26
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， 和r如说明书中所定义，其制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US07820694B2
公开(公告)日：2010-10-26
申请号：US12577855
申请日：2009-10-13
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61K31/395 , C07D215/26 , C07D215/22
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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