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公开(公告)号：US06490405B1
公开(公告)日：2002-12-03
申请号：US09106444
申请日：1998-06-29
申请人： Robin Speed , William C. Powell
发明人： Robin Speed , William C. Powell
IPC分类号： H04N591
摘要： The modification of timestamps of streams of data packets for seamless branching is disclosed. In one aspect of the invention, a computerized system has a plurality of multimedia play devices, and a multimedia read device. Each play device receives and plays data intended for that device. The multimedia read device reads a stream of packets of data, decodes the packets into data, and sends the data to a corresponding play device at appropriate times. The appropriate time is based on relative timestamps accounting for accumulated time gaps resulting from branches within the stream. The invention has applications including digital video disc (DVD) playback.
摘要翻译： 公开了用于无缝分支的数据分组流的时间戳的修改。 在本发明的一个方面，计算机化系统具有多个多媒体播放设备和多媒体读取设备。 每个播放设备接收并播放旨在用于该设备的数据。 多媒体读取设备读取数据包流，将数据包解码为数据，并在适当的时间将数据发送到相应的播放设备。 适当的时间是基于相对时间戳来计算流内部分支产生的累积时间间隔。 本发明具有数字视频盘（DVD）播放的应用。
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公开(公告)号：US20090017050A1
公开(公告)日：2009-01-15
申请号：US12171889
申请日：2008-07-11
IPC分类号： A61K39/00 , C07K14/00 , G01N1/30 , G01N33/566
CPC分类号： C07K16/2863 , C07K2317/33 , C07K2317/34 , G01N33/57484 , G01N2333/71 , G01N2500/02 , G01N2800/52
摘要： Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.
摘要翻译： 本文公开了抗原结合分子，例如抗体，其特异性识别与一个或多个调节分子（例如细胞因子信号传导抑制因子（“SOCS”）蛋白）相互作用的部分EGFR C末端（细胞内）调节结构域， 。 在某些正常或肿瘤细胞和/或组织中，该区域对所公开的抗原结合分子是不可接近的。 因此，这种抗原结合分子至少可用于询问EGFR的调节状态，预测癌症患者对EGFR抑制剂疗法的反应和/或预测肿瘤的侵袭性。
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3.发明授权Methods of predicting response of a neoplasm to an EGFR inhibitor and detecting interactions between EGFR and an EGFR regulatory protein 有权预测肿瘤对EGFR抑制剂的反应并检测EGFR与EGFR调节蛋白之间的相互作用的方法公开(公告)号：US08329421B2
公开(公告)日：2012-12-11
申请号：US12668991
申请日：2008-07-11
IPC分类号： G01N33/53 , G01N33/563 , G01N33/574 , G01N33/577 , G01N33/58
CPC分类号： C07K16/2863 , C07K2317/33 , C07K2317/34 , G01N33/57484 , G01N2333/71 , G01N2500/02 , G01N2800/52
摘要： Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.
摘要翻译： 本文公开了抗原结合分子，例如抗体，其特异性识别与一个或多个调节分子（例如细胞因子信号传导抑制因子（SOCS）蛋白）相互作用的EGFR C末端（细胞内）调节结构域的一部分。 在某些正常或肿瘤细胞和/或组织中，该区域对所公开的抗原结合分子是不可接近的。 因此，这种抗原结合分子至少可用于询问EGFR的调节状态，预测癌症患者对EGFR抑制剂疗法的反应和/或预测肿瘤的侵袭性。
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公开(公告)号：US5264673A
公开(公告)日：1993-11-23
申请号：US771645
申请日：1991-10-03
申请人： William C. Powell
发明人： William C. Powell
CPC分类号： H01H71/528 , H01H71/46 , H01H2071/467
摘要： A circuit interrupter manually opens and closes its contacts by use of a manually rotatable handle which acts through a collapsible linkage rotatably connected to a crank extension of the handle and rotatably connected to a rotatably movable contact support. The rotatable contact support is urged away from closed contact position by a main spring and in moving from one contact position to the other the axis of the rotatable connection between the handle crank passes over a center line defined by the center of rotation of the handle and the rotatable connection between the linkage and the movable contact support providing a toggle action to hold the movable contact in selected open or closed position. Upon overload, the mechanism causes collapse of the collapsible linkage allowing the movable contact support to move and open the contacts. A center trip stop member, normally not interfering with the handle, is supported to be moved relative to the mechanism by structure connected to the movable contact arm to a position obstructing the handle switch movement and holding it in center trip position. An auxiliary switch for indicating trip condition may be provided with the circuit interrupter. A spring biased switch operator may be operated by a rotatable actuator pivotally supported on a frame member of the circuit interrupter whereby the collapsing linkage rotates the actuation into engagement with the switch operator of the auxiliary switch, thus actuating the auxiliary switch.
摘要翻译： 电路断路器通过使用可手动旋转的手柄来手动地打开和关闭其触点，所述手柄通过可旋转地连接到手柄的曲柄延伸部并可旋转地连接到可旋转地移动的触点支撑件的可折叠连杆而起作用。 可旋转接触支撑件被主弹簧推离远离闭合接触位置，并且从一个接触位置移动到另一个，手柄曲柄之间的可旋转连接的轴线越过由手柄的旋转中心限定的中心线， 联动装置和可动触头支架之间的可旋转连接件提供肘节动作，以将可动触点保持在选定的打开或关闭位置。 在过载时，机构引起可折叠联动装置的塌陷，允许可动触头支架移动并打开触点。 通常不干扰手柄的中心跳闸止动构件被支撑成通过结构连接到可动接触臂而相对于机构移动到阻碍手柄开关运动并将其保持在中心跳闸位置的位置。 用于指示跳闸状态的辅助开关可以与电路断续器一起提供。 弹簧偏置的开关操作器可以由枢转地支撑在电路断路器的框架构件上的可旋转致动器操作，由此塌陷联动装置将致动转动与辅助开关的开关操作器接合，从而致动辅助开关。
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公开(公告)号：US20100291593A1
公开(公告)日：2010-11-18
申请号：US12668955
申请日：2008-07-11
申请人： William C. Powell , Debra A. Gordon
发明人： William C. Powell , Debra A. Gordon
IPC分类号： G01N33/574 , G01N33/566 , C07K16/28
CPC分类号： C07K16/2863 , C07K2317/33 , C07K2317/34 , G01N33/57484 , G01N2333/71 , G01N2500/02 , G01N2800/52
摘要： Disclosed herein are methods for identifying diagnostic reagents (e.g., antigen-binding molecules, such as antibodies) that are useful, for instance, as primary diagnostic, prognostic, and/or predictive (e.g., companion diagnostic) reagents in a disease state, such as cancer.
摘要翻译： 本文公开了用于鉴定诊断试剂（例如，抗原结合分子，例如抗体）的方法，其可用于例如疾病状态中的主要诊断，预后和/或预测（例如，伴随诊断）试剂，例如 作为癌症。
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6.发明申请ANTIBODIES SPECIFIC FOR THE C-TERMINAL REGULATORY DOMAIN OF EGFR AND THEIR USE 有权EGFR及其使用的C末端调节区特异性抗体公开(公告)号：US20100285025A1
公开(公告)日：2010-11-11
申请号：US12668991
申请日：2008-07-11
IPC分类号： A61K39/395 , C07K7/08 , C07K16/28 , G01N33/574 , A61P35/00
CPC分类号： C07K16/2863 , C07K2317/33 , C07K2317/34 , G01N33/57484 , G01N2333/71 , G01N2500/02 , G01N2800/52
摘要： Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling (“SOCS”) proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.
摘要翻译： 本文公开了抗原结合分子，例如抗体，其特异性识别与一个或多个调节分子（例如细胞因子信号传导抑制因子（“SOCS”）蛋白）相互作用的部分EGFR C末端（细胞内）调节结构域， 。 在某些正常或肿瘤细胞和/或组织中，该区域对所公开的抗原结合分子是不可接近的。 因此，这种抗原结合分子至少可用于询问EGFR的调节状态，预测癌症患者对EGFR抑制剂疗法的反应和/或预测肿瘤的侵袭性。
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公开(公告)号：US07584502B2
公开(公告)日：2009-09-01
申请号：US10838532
申请日：2004-05-03
申请人： James M. Alkove , Kirt A. Debique , Alexandre V. Grigorovitch , William C. Powell , Jeffrey Richard McKune
发明人： James M. Alkove , Kirt A. Debique , Alexandre V. Grigorovitch , William C. Powell , Jeffrey Richard McKune
CPC分类号： G06F21/10 , G06F21/53 , G06F21/6209
摘要： The described embodiments relate to data security. One exemplary system includes a first component associated with data on which an action can be performed and a second component configured to perform the action on the data. The system also includes a third component configured to ascertain the action and determine, as a function of the action, at least one policy to be implemented prior to allowing the second component to access the data.
摘要翻译： 所描述的实施例涉及数据安全性。 一个示例性系统包括与能够执行动作的数据相关联的第一组件和被配置为对数据执行动作的第二组件。 系统还包括配置成确定动作的第三组件，并且根据动作确定在允许第二组件访问数据之前要实现的至少一个策略。
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公开(公告)号：US06636270B2
公开(公告)日：2003-10-21
申请号：US09738908
申请日：2000-12-14
IPC分类号： H04N9475
CPC分类号： H04N21/4305 , G06F1/14 , H04J3/0632 , H04J3/0685
摘要： In accordance with certain aspects of the present invention, an algorithm is provided that can be used to detect and track the difference between an on-host clock (i.e., “host clock”) and a remote clock (i.e., “reference clock”). As part of the algorithm, a scaling value is computed and tracked over time. The scaling value, when applied to the host clock, results in clock values that increase at substantially the same rate as the reference clock itself increases. Hence, the host clock will have been slaved to the reference clock.
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