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公开(公告)号:US07799827B2
公开(公告)日:2010-09-21
申请号:US10507067
申请日:2003-03-07
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/335 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了具有式(I)的化合物:另外提供了其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病)的方法,其中R1-R11, X,Y,Z和n如本文所定义。
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公开(公告)号:US08329742B2
公开(公告)日:2012-12-11
申请号:US12839873
申请日:2010-07-20
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/355 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了使用具有式(I)的化合物在治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,t,X,Y,Z和n 如本文所定义。
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公开(公告)号:US20110144101A1
公开(公告)日:2011-06-16
申请号:US12839873
申请日:2010-07-20
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供了使用具有式(I)的化合物在治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,t,X,Y,Z和n 如本文所定义。
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公开(公告)号:US20130196987A1
公开(公告)日:2013-08-01
申请号:US13663857
申请日:2012-10-30
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: C07D405/12 , C07D491/044 , C07D313/00
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译: 本发明提供了化合物,其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管生成的疾病的方法。
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公开(公告)号:US20060247448A1
公开(公告)日:2006-11-02
申请号:US10507067
申请日:2003-03-07
申请人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
发明人: Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: C07D313/08
CPC分类号: C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译: 本发明提供具有式(I)的化合物:另外提供其合成方法及其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R 1,R 11,X,Y,Z和n如本文所定义。
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公开(公告)号:US07915306B2
公开(公告)日:2011-03-29
申请号:US10657910
申请日:2003-09-09
申请人: Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
发明人: Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
IPC分类号: A61K31/335
CPC分类号: C07D493/04 , C07D313/00
摘要: The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).
摘要翻译: 本发明提供了包含具有式(I)的化合物的组合物:另外提供了其用于治疗各种疾病(包括炎性或自身免疫性疾病)以及涉及恶性肿瘤或增加血管发生的疾病的方法,其中R1-R11,X,Y, Z和n如本文所定义。 在某些实施方案中,组合物用于全身(例如口服)给药。 在某些实施方案中,用于治疗各种疾病(包括炎性或自身免疫性疾病)的方法包括全身(例如,口服)向有需要的受试者施用治疗有效量的式(I)化合物。
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公开(公告)号:US20070143723A1
公开(公告)日:2007-06-21
申请号:US11642725
申请日:2006-12-21
申请人: Yoshiyuki Kawakami
发明人: Yoshiyuki Kawakami
IPC分类号: G06F17/50
CPC分类号: G06F17/5031
摘要: In timing verification considering process variations in the fabrication of semiconductor integrated circuits, parasitic element extraction results are obtained with high accuracy by considering variations in interconnect configuration occurring randomly inside LSI to perform timing verification of worst-case or best-case simulation. For example, a plurality of capacitance libraries are prepared according to process variations in the fabrication of semiconductor integrated circuits, such as variations in interconnect width, interconnect film thickness and interlayer film thickness, and one is selected among these capacitance libraries properly according to the target layout. In this way, parasitic element extraction results for worst-case or best-case simulation can be obtained with high accuracy for the target layout.
摘要翻译: 考虑到半导体集成电路制造中的工艺变化的定时验证,通过考虑在LSI内部随机发生的互连配置的变化来实现最坏情况或最佳情况模拟的定时验证,从而以高精度获得寄生元件提取结果。 例如,根据半导体集成电路的制造中的工艺变化制备多个电容库,例如互连宽度,互连膜厚度和层间膜厚度的变化,并且根据目标适当选择这些电容库 布局。 以这种方式,可以以目标布局的高精度获得最坏情况或最佳情况下的寄生元件提取结果。
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公开(公告)号:US07541625B2
公开(公告)日:2009-06-02
申请号:US11883539
申请日:2006-03-03
申请人: Yoshiyuki Kawakami
发明人: Yoshiyuki Kawakami
IPC分类号: H01L21/768
CPC分类号: H01L27/0203 , H01L21/31053 , H01L21/7684 , H01L23/5222 , H01L23/528 , H01L2924/0002 , H01L2924/00
摘要: When dummy patterns are arranged to planarize LSI layout patterns, a plurality of dummy patterns 1 are arranged in a wiring layer in which signal wiring patterns 2 are formed, so as to be inclined at an angle of generally 45 degrees toward the associated signal wiring patterns 2. These dummy patterns 1 cross signal wiring patterns 3 formed in another vertically adjacent wiring layer to have an inclination angle of generally 45 degrees. A plurality of dummy patterns 13 are located in the wiring layer in which the signal wiring patterns 3 are formed, so as to be inclined at an angle of generally 45 degrees toward the associated signal wiring patterns 3. The dummy patterns 1 formed in one of the adjacent wiring layers cross the dummy patterns 13 formed in the other wiring layer at an angle of generally 90 degrees. This reduces fluctuations in wiring capacitance and equalizes fluctuations in the wiring capacitance to the maximum extent.
摘要翻译: 当布置虚拟图形以平坦化LSI布局图案时,在其中形成信号布线图案2的布线层中布置多个虚设图案1,以便以相对于相关联的信号布线图案大致45度的角度倾斜 这些虚拟图形1在另一个垂直相邻布线层中形成的交叉信号布线图案3具有大致45度的倾斜角。 多个虚设图形13位于其中形成信号布线图案3的布线层中,以相对于相关联的信号布线图案3以大致45度的角度倾斜。虚设图案1形成为 相邻的布线层以一般为90度的角度与形成在另一布线层中的虚设图案13交叉。 这样可以减少布线电容的波动,并最大限度地均衡布线电容的波动。
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公开(公告)号:US06498515B2
公开(公告)日:2002-12-24
申请号:US10142969
申请日:2002-05-13
IPC分类号: H03K1920
CPC分类号: H03K19/00323 , G06F17/505
摘要: A logical design method for a semiconductor integrated circuit includes the steps of: a) generating a circuit at a logical level so as to meet given functions and specifications; b) extracting a critical path, which will cause the longest delay, from the circuit generated in the step a); c) counting how many times a path leading from each input terminal to an output terminal in every logic cell of the circuit has operated; d) calculating a degradation rate associated with the path leading from each said input terminal to the output terminal in each said logic cell on the critical path by reference to the number of times of operation obtained in the step c); and e) exchanging a connection to one of the input terminals of each said logic cell, which terminal is associated with the critical path, with a connection to another one of the input terminals of the logic cell, which terminal is associated with another path corresponding to a lower degradation rate than that of the critical path, by reference to the degradation rates obtained in the step d).
摘要翻译: 一种用于半导体集成电路的逻辑设计方法包括以下步骤:a)产生逻辑电平的电路以满足给定的功能和规格; b)提取从步骤a)中产生的电路产生最长延迟的关键路径; c)计算从电路的每个逻辑单元中的每个输入端子到输出端子的路径的操作次数; d)通过参考步骤c)中获得的操作次数,计算在关键路径上的每个所述逻辑单元中从每个所述输入端子到输出端子的路径相关联的退化率; 以及e)通过与逻辑单元的另一个输入端子的连接来与每个所述逻辑单元的哪个终端与关键路径相关联的输入终端之一交换连接,该终端与另一路径相关联 通过参考在步骤d)中获得的降解速率降低到关键路径的降解速率。
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公开(公告)号:US06396307B1
公开(公告)日:2002-05-28
申请号:US09573568
申请日:2000-05-19
IPC分类号: H03K1920
CPC分类号: H03K19/00323 , G06F17/505
摘要: A logical design method for a semiconductor integrated circuit includes the steps of: a) generating a circuit at a logical level so as to meet given functions and specifications; b) extracting a critical path, which will cause the longest delay, from the circuit generated in the step a); c) counting how many times a path leading from each input terminal to an output terminal in every logic cell of the circuit has operated; d) calculating a degradation rate associated with the path leading from each said input terminal to the output terminal in each said logic cell on the critical path by reference to the number of times of operation obtained in the step c); and e) exchanging a connection to one of the input terminals of each said logic cell, which terminal is associated with the critical path, with a connection to another one of the input terminals of the logic cell, which terminal is associated with another path corresponding to a lower degradation rate than that of the critical path, by reference to the degradation rates obtained in the step d).
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