专利检索 ap:"Yoshikazu Kuboi" 第 1 页

1.

发明授权
Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物

公开(公告)号：US07799827B2

公开(公告)日：2010-09-21

申请号：US10507067

申请日：2003-03-07

申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/335 , C07D313/00

CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411

摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

摘要翻译： 本发明提供了具有式（I）的化合物：另外提供了其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病）的方法，其中R1-R11， X，Y，Z和n如本文所定义。

2.

发明授权
Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物

公开(公告)号：US07915306B2

公开(公告)日：2011-03-29

申请号：US10657910

申请日：2003-09-09

申请人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda

发明人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/335

CPC分类号： C07D493/04 , C07D313/00

摘要： The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).

摘要翻译： 本发明提供了包含具有式（I）的化合物的组合物：另外提供了其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，X，Y， Z和n如本文所定义。在某些实施方案中，组合物用于全身（例如口服）给药。在某些实施方案中，用于治疗各种疾病（包括炎性或自身免疫性疾病）的方法包括全身（例如，口服）向有需要的受试者施用治疗有效量的式（I）化合物。

3.

发明授权
Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物

公开(公告)号：US08329742B2

公开(公告)日：2012-12-11

申请号：US12839873

申请日：2010-07-20

申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/355 , C07D313/00

CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411

摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

4.

发明申请
MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 有权
标题翻译：大环化合物作为药物有用

公开(公告)号：US20110144101A1

公开(公告)日：2011-06-16

申请号：US12839873

申请日：2010-07-20

申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00

CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411

摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

$Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine$

5.

发明授权
Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine 有权
标题翻译：使用抗CX3CR1抗体，抗分解蛋白抗体和fractalkine

公开(公告)号：US07390490B1

公开(公告)日：2008-06-24

申请号：US11225829

申请日：2005-09-13

申请人： Toshio Imai , Miyuki Nishimura , Kenzo Muramoto , Yoshikazu Kuboi

发明人： Toshio Imai , Miyuki Nishimura , Kenzo Muramoto , Yoshikazu Kuboi

IPC分类号： A61K39/395 , C07K16/24 , C07K16/28

CPC分类号： G01N33/56972 , A61K2039/505 , C07K16/24 , C07K16/2866 , Y10S424/81

摘要： There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotoxic activity of killer lymphocytes by suppressing an interaction between CX3CR1 and fractalkine.

摘要翻译： 提供了针对CX3CR1和fractalkine的抗体的用途。通过使用抗CX3CR1抗体可以容易地鉴定，消除和分离杀伤淋巴细胞。此外，可以提供通过抑制CX3CR1与fractalkine之间的相互作用来抑制杀伤淋巴细胞的趋化性和细胞毒性的抗体药物。

6.

发明授权
Cyclooctanone derivatives and cyclodecanone derivative, and use thereof 失效
标题翻译：环辛酮衍生物和环十一酮衍生物及其用途

公开(公告)号：US06949585B2

公开(公告)日：2005-09-27

申请号：US10473568

申请日：2002-04-01

申请人： Yoshihito Eguchi , Ken-ichi Chiba , Masaki Goto , Hiroshi Obaishi , Yoshikazu Kuboi

发明人： Yoshihito Eguchi , Ken-ichi Chiba , Masaki Goto , Hiroshi Obaishi , Yoshikazu Kuboi

IPC分类号： A61K31/12 , A61K31/235 , A61K31/24 , A61K31/4402 , A61P1/04 , A61P1/16 , A61P3/10 , A61P13/12 , A61P17/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P43/00 , C07C49/657 , C07C49/747 , C07C49/753 , C07C205/57 , C07D207/12 , C07D401/04 , C07D453/02 , C07C69/76 , C07C205/00

CPC分类号： C07D401/04 , A61K31/12 , A61K31/235 , A61K31/24 , A61K31/4402 , C07C49/657 , C07C49/747 , C07C49/753 , C07C205/57 , C07D207/12 , C07D453/02

摘要： The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -DE- represents a group represented by —CH2CH2— or —CH═CH—; W represents a group represented by —CH2—, —CH2CH2—, —CH═CH— or —CH═; the partial structure >XY— represents a group represented by >CH—(CH2)n—, >C═CH—, >CH—CH2—CH(OH)—, >CH—CH2—C(═O)—, >CH—O— or >CH—O—CO—, provided that when W is —CH═, then XY— represents C—(CH2)p—; Z represents a divalent aliphatic hydrocarbon group; R1 and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1].

摘要翻译： 本发明提供具有细胞因子产生抑制活性的化合物，可用于治疗与细胞因子相关的疾病。该化合物由以下通式（I）表示[其中A表示可以被取代的环状基团; 部分结构-D E-表示由-CH 2 CH 2 - 或-CH-CH-表示的基团。 W表示由-CH 2 - ， - CH 2 CH 2 - ， - CH-CH-或-CH-表示的基团。部分结构> X Y-表示由CH-（CH 2）n - ，> C-CH-，CH -CH 2 OH（OH） - ，> CH-CH 2 -C（-O） - ，> CH-O-或> CH-O-CO- 条件是当W是-CH-时，则X Y-表示C-（CH 2）

$Treating inflammatory diseases with antibodies that inhibit fractalkine-CXCR1 interaction$

7.

发明授权
Treating inflammatory diseases with antibodies that inhibit fractalkine-CXCR1 interaction 有权
标题翻译：用抑制fractalkine-CXCR1相互作用的抗体治疗炎性疾病

公开(公告)号：US08518401B1

公开(公告)日：2013-08-27

申请号：US11718246

申请日：2005-10-31

申请人： Yoshikazu Kuboi , Toshio Imai , Miyuki Nishimura , Keiko Mizuno

发明人： Yoshikazu Kuboi , Toshio Imai , Miyuki Nishimura , Keiko Mizuno

IPC分类号： A61K39/395

CPC分类号： C07K16/24 , A61K31/00 , A61K2039/505 , C07K2317/76

摘要： A therapeutic agent for an inflammatory disease comprising an antibody or a CX3CR1 antagonist that inhibits an interaction of fractalkine and CX3CR1 is provided.

摘要翻译： 提供一种炎症性疾病的治疗剂，其包含抑制分解素与CX3CR1相互作用的抗体或CX3CR1拮抗剂。