公开(公告)号：US11982657B2

公开(公告)日：2024-05-14

申请号：US17806764

申请日：2022-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Nadja Arens ,  Andrea Geistanger ,  Anton Hilger ,  Daniel Intelmann ,  Shirin Shahriari

IPC: G01N30/72 ,  G01N30/86

CPC classification number: G01N30/8665 ,  G01N30/7233

Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.

公开(公告)号：US12074015B2

公开(公告)日：2024-08-27

申请号：US17805133

申请日：2022-06-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Geistanger ,  Daniel Intelmann ,  Shirin Shahriari ,  Anton Hilger

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

公开(公告)号：US20230251277A1

公开(公告)日：2023-08-10

申请号：US18125708

申请日：2023-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Silvia Baecher ,  Andrea Geistanger ,  Dominik Gruber ,  Hans-Peter Josel

IPC: G01N33/82

CPC classification number: G01N33/82

Abstract: The present invention relates to a method and the use thereof for for determining the level of Vitamin D and metabolites thereof. Further, it is an object of the present invention to provide a kit and the use thereof for determining the level of Vitamin D and metabolites thereof.

公开(公告)号：US20220293404A1

公开(公告)日：2022-09-15

申请号：US17805133

申请日：2022-06-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Geistanger ,  Daniel Intelmann ,  Shirin Shahriari ,  Anton Hilger

IPC: H01J49/00

Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

公开(公告)号：US20220308024A1

公开(公告)日：2022-09-29

申请号：US17806764

申请日：2022-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Nadja Arens ,  Andrea Geistanger ,  Anton Hilger ,  Daniel Intelmann ,  Shirin Shahriari

IPC: G01N30/86 ,  G01N30/72

Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.

公开(公告)号：US20170115294A1

公开(公告)日：2017-04-27

申请号：US15399801

申请日：2017-01-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Ursula Garczarek ,  Andrea Geistanger ,  Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Freidemann Krause ,  Michael Pfeffer ,  Wolfgang Rollinger ,  Michael Tacke ,  Michael Thierolf

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  C12Q1/6886 ,  G01N2333/4727 ,  G01N2333/805 ,  G01N2333/8146 ,  G01N2333/9121

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

公开(公告)号：US20150192587A1

公开(公告)日：2015-07-09

申请号：US14463975

申请日：2014-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Ursula Garczarek ,  Andrea Geistanger ,  Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Friedemann Krause ,  Michael Pfeffer ,  Wolfgang Rollinger ,  Michael Tacke ,  Michael Thierolf

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  C12Q1/6886 ,  G01N2333/4727 ,  G01N2333/805 ,  G01N2333/8146 ,  G01N2333/9121

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.