公开(公告)号：US20160169895A1

公开(公告)日：2016-06-16

申请号：US15046525

申请日：2016-02-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Marie-Luise Hagmann ,  Johann Karl ,  Julia Riedlinger ,  Markus Roessler ,  Michael Tacke

IPC: G01N33/573

CPC classification number: G01N33/573 ,  G01N33/54306 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57488 ,  G01N2333/922 ,  G01N2800/52 ,  G01N2800/7028 ,  G16H50/30 ,  Y02A90/26

Abstract: Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal.

公开(公告)号：US20170115294A1

公开(公告)日：2017-04-27

申请号：US15399801

申请日：2017-01-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Ursula Garczarek ,  Andrea Geistanger ,  Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Freidemann Krause ,  Michael Pfeffer ,  Wolfgang Rollinger ,  Michael Tacke ,  Michael Thierolf

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  C12Q1/6886 ,  G01N2333/4727 ,  G01N2333/805 ,  G01N2333/8146 ,  G01N2333/9121

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

公开(公告)号：US20150192587A1

公开(公告)日：2015-07-09

申请号：US14463975

申请日：2014-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Ursula Garczarek ,  Andrea Geistanger ,  Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Friedemann Krause ,  Michael Pfeffer ,  Wolfgang Rollinger ,  Michael Tacke ,  Michael Thierolf

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  C12Q1/6886 ,  G01N2333/4727 ,  G01N2333/805 ,  G01N2333/8146 ,  G01N2333/9121

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

公开(公告)号：US20160109461A1

公开(公告)日：2016-04-21

申请号：US14919456

申请日：2015-10-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Johann Karl ,  Julia Riedlinger ,  Norbert Wild

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6884 ,  G01N2333/914 ,  G01N2333/916 ,  G01N2800/122 ,  G01N2800/60

Abstract: An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein FEN1 in said sample in vitro.

Abstract translation: 一种协助慢性阻塞性肺疾病（COPD）评估的体外方法。 本公开还涉及通过在体外测量所述样品中的蛋白质FEN1来评估来自个体的样品的COPD的方法。

公开(公告)号：US20150126401A1

公开(公告)日：2015-05-07

申请号：US14598630

申请日：2015-01-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Johann Karl ,  Norbert Wild ,  Ursula Garczarek

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  G01N33/721 ,  G01N2333/4727 ,  G01N2333/805

Abstract: The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of the hemoglobin/haptoglobin complex and calprotectin and correlating the concentrations determined to the absence or presence of colorectal cancer. To further improve the assessment of colorectal cancer based on a method of this invention the level of one or more additional marker may be determined together with the hemoglobin/haptoglobin complex and calprotectin in a stool sample and be correlated to the absence or presence of colorectal cancer. The invention also relates to the use of a marker panel comprising the hemoglobin/haptoglobin complex and calprotectin in the early diagnosis of colorectal cancer and it teaches a kit for performing the method of the invention.

Abstract translation: 本发明涉及一种协助评估结肠直肠癌的方法。 该方法特别用于评估体外存在或不存在结肠直肠癌。 该方法例如通过分析生物化学标记来实施，包括在粪便样品中测量血红蛋白/触珠蛋白复合物和钙卫蛋白的浓度，并将确定的浓度与不存在或存在结肠直肠癌相关联。 为了进一步改进基于本发明方法的结肠直肠癌的评估，可以在粪便样品中与血红蛋白/触珠蛋白复合物和钙卫蛋白一起测定一种或多种另外的标记物的水平，并与结肠直肠癌的存在或不存在相关 。 本发明还涉及包含血红蛋白/触珠蛋白复合物和钙卫蛋白的标记物在早期诊断结肠直肠癌中的用途，并且其教导了用于实施本发明方法的试剂盒。

公开(公告)号：US20150072355A1

公开(公告)日：2015-03-12

申请号：US14529702

申请日：2014-10-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Norbert Wild ,  Marie-Luise Hagmann ,  Johann Karl ,  Julia Riedlinger ,  Markus Roessler ,  Michael Tacke

IPC: G01N33/543 ,  G06F19/00

CPC classification number: G01N33/573 ,  G01N33/54306 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57488 ,  G01N2333/922 ,  G01N2800/52 ,  G01N2800/7028 ,  G16H50/30 ,  Y02A90/26

Abstract: Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal.

Abstract translation: 提供了帮助评估癌症的方法，包括使用Flap核酸内切酶-1蛋白（= FEN1）作为不同癌症类型的通用标记。 特别地，公开了从样品中得到的来自个体的液体样品中评估癌症的方法，其包括测量样品中的FEN1。 FEN1的测量可用于癌症的早期检测或用于手术切除肿瘤的患者的监测。