公开(公告)号：US11740254B2

公开(公告)日：2023-08-29

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro Ota ,  Takaaki Hagiwara ,  Yoshihiro Yamashita ,  Koshin Hamasaki ,  Michaela Windfuhr ,  Heike Guggemos ,  Johannes Stoeckel ,  Guenter Ziegler ,  Michael Kuehnl

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  G01N35/1016 ,  G01N2035/1025

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US11726044B2

公开(公告)日：2023-08-15

申请号：US16739236

申请日：2020-01-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reinhold Kraemer ,  Michael Kuehnl ,  Uwe Mertsch ,  Marion Borchers

IPC: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N21/84

CPC classification number: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N2021/4726 ,  G01N2021/8411 ,  G01N2458/30

Abstract: A method of monitoring detection of an analyte in a liquid sample using a measuring cell, the measuring cell comprising a working electrode for excitation of electrochemiluminescence in the liquid sample, an optical detector for detecting the excited electrochemiluminescence, the excitation and detection being performed in an measurement cycle, the measurement cycle comprising transporting the liquid sample via a transport path to the working electrode using a support liquid, the method comprising: coupling light of a light source into the transport path during part of the measurement cycle, the transport path forming a light guide between the light source and the optical detector, detecting the coupled light by the optical detector, analyzing the detected light for a gas bubble in the transport path, providing a measurement state if the result of the analysis deviates from a target state regarding the presence of a gas bubble in the transport path.

公开(公告)号：US20200150046A1

公开(公告)日：2020-05-14

申请号：US16739236

申请日：2020-01-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reinhold Kraemer ,  Michael Kuehnl ,  Uwe Mertsch ,  Marion Borchers

IPC: G01N21/69 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N21/47

Abstract: A method of monitoring detection of an analyte in a liquid sample using a measuring cell, the measuring cell comprising a working electrode for excitation of electrochemiluminescence in the liquid sample, an optical detector for detecting the excited electrochemiluminescence, the excitation and detection being performed in an measurement cycle, the measurement cycle comprising transporting the liquid sample via a transport path to the working electrode using a support liquid, the method comprising: coupling light of a light source into the transport path during part of the measurement cycle, the transport path forming a light guide between the light source and the optical detector, detecting the coupled light by the optical detector, analyzing the detected light for a gas bubble in the transport path, providing a measurement state if the result of the analysis deviates from a target state regarding the presence of a gas bubble in the transport path.