公开(公告)号：US20210381987A1

公开(公告)日：2021-12-09

申请号：US17405742

申请日：2021-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter JOSEL ,  Herbert ANDRES ,  Michaela WINDFUHR ,  Oliver LARBOLETTE ,  Stefan QUINT

IPC: G01N21/76 ,  G01N33/543 ,  C07F15/00 ,  G01N21/66

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

公开(公告)号：US20190310275A1

公开(公告)日：2019-10-10

申请号：US16307787

申请日：2017-04-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS INC.

Inventor： Takeshi ISHIDA ,  Sakuichiro ADACHI ,  Yoshihiro YAMASHITA ,  Shunichirou NOBUKI ,  Hisashi YABUTANI ,  Isao YAMAZAKI ,  Michaela WINDFUHR ,  Bernhard HAUPTMANN ,  Simon KUESTER

IPC: G01N35/00 ,  G01N35/10 ,  A61L2/10 ,  A61L2/24

Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.

公开(公告)号：US20220283094A1

公开(公告)日：2022-09-08

申请号：US17631061

申请日：2019-07-31

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Toshiro SAITO ,  Kyoko IMAI ,  Francesco PAOLUCCI ,  Massimo MARCACCIO ,  Giovanni VALENTI ,  Alessandra ZANUT ,  Michaela WINDFUHR ,  Hans-Peter JOSEL

IPC: G01N21/66 ,  G01N33/543 ,  B01L3/00

Abstract: An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.

公开(公告)号：US20200240981A1

公开(公告)日：2020-07-30

申请号：US16652698

申请日：2019-01-29

Applicant: HITACHI HIGH-TECH CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Tatsuki TAKAKURA ,  Kenta IMAI ,  Takaaki HAGIWARA ,  Yoshihiro YAMASHITA ,  Taku SAKAZUME ,  Beatus OFENLOCH-HAEHNLE ,  Michaela WINDFUHR ,  Ursula PAUSELIUS-FUCHS ,  Rita HAERTEIS

IPC: G01N33/543 ,  G01N35/02

Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.

公开(公告)号：US20200209273A1

公开(公告)日：2020-07-02

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Technologies Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro OTA ,  Takaaki HAGIWARA ,  Yoshihiro YAMASHITA ,  Koshin HAMASAKI ,  Michaela WINDFUHR ,  Heike GUGGEMOS ,  Johannes STOECKEL ,  Guenter ZIEGLER ,  Michael KUEHNL

IPC: G01N35/10

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US20240044804A9

公开(公告)日：2024-02-08

申请号：US17405742

申请日：2021-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter JOSEL ,  Herbert ANDRES ,  Michaela WINDFUHR ,  Oliver LARBOLETTE ,  Stefan QUINT

IPC: G01N21/76 ,  G01N33/543 ,  C07F15/00 ,  G01N21/66

CPC classification number: G01N21/76 ,  G01N33/5438 ,  C07F15/0033 ,  C07F15/0046 ,  G01N21/66 ,  G01N2458/30 ,  G01N27/308

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

公开(公告)号：US20200171182A1

公开(公告)日：2020-06-04

申请号：US16640971

申请日：2018-09-10

Applicant: Hitachi High-Technologies Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Hisashi YABUTANI ,  Takeshi ISHIDA ,  Yoshihiro YAMASHITA ,  Taku SAKAZUME ,  Michaela WINDFUHR ,  Bernhard HAUPTMANN ,  Andreas FINKE

IPC: A61L2/10 ,  C02F1/32

Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container. The third electric power switch is opened when an amount of the reagent within the shared reagent storage container is equal to or smaller than a constant value. When one of the first electric power switch, the second electric power switch, and the third electric power switch is opened, supply of the electric power to the ultraviolet LED is intercepted.