公开(公告)号：US20230121541A1

公开(公告)日：2023-04-20

申请号：US17961200

申请日：2022-10-06

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886 ,  C12Q1/6851

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

公开(公告)号：US11505830B2

公开(公告)日：2022-11-22

申请号：US15993375

申请日：2018-05-30

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q1/686

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

公开(公告)号：US20180346994A1

公开(公告)日：2018-12-06

申请号：US15993375

申请日：2018-05-30

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/156 ,  C12Q2537/143 ,  C12Q2561/101

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.