公开(公告)号：US20230121541A1

公开(公告)日：2023-04-20

申请号：US17961200

申请日：2022-10-06

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886 ,  C12Q1/6851

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

公开(公告)号：US20160304937A1

公开(公告)日：2016-10-20

申请号：US15130486

申请日：2016-04-15

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Rajiv Dua ,  Dwight Kuo ,  Xiaoju Max Ma ,  Ellen Ordinario

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q2537/143 ,  C12Q2537/16 ,  C12Q2539/105 ,  C12Q2545/101 ,  C12Q2561/101 ,  C12Q2561/113 ,  C12Q2563/107

摘要： Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.

摘要翻译： 本文提供了用于检测基因融合物的方法和组合物，例如与癌症相关。 本发明的方法和组合物可用于以非常高的灵敏度和特异性检测基因融合体。 本发明的方法和组合物可以检测基因融合物，例如来自血浆样品的游离循环肿瘤RNA。

公开(公告)号：US11505830B2

公开(公告)日：2022-11-22

申请号：US15993375

申请日：2018-05-30

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q1/686

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

公开(公告)号：US10253349B2

公开(公告)日：2019-04-09

申请号：US15130486

申请日：2016-04-15

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Rajiv Dua ,  Dwight Kuo ,  Xiaoju Max Ma ,  Ellen Ordinario

IPC分类号： C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6858 ,  C12Q1/686

摘要： Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.

公开(公告)号：US20180346994A1

公开(公告)日：2018-12-06

申请号：US15993375

申请日：2018-05-30

申请人： Roche Molecular Systems, Inc.

发明人： Ann Begovich ,  Cindy Cheung ,  Javelin Chi ,  Grantland Hillman ,  Dwight Kuo ,  Michael Lee ,  Chitra Manohar ,  Xiaoju Max Ma ,  Ellen Ordinario ,  Jaya Rajamani ,  Huan Truong

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/156 ,  C12Q2537/143 ,  C12Q2561/101

摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.