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公开(公告)号：US6143516A
公开(公告)日：2000-11-07
申请号：US404926
申请日：1999-09-24
CPC分类号： C12Q1/18 , Y10S435/911 , Y10S435/968
摘要： Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.
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2.发明授权Identification of novel antimicrobial agents using membrane potential indicator dyes 失效使用膜电位指示剂染料鉴定新型抗微生物剂公开(公告)号：US06455271B1
公开(公告)日：2002-09-24
申请号：US09626995
申请日：2000-07-27
IPC分类号： C12Q102
CPC分类号： C12Q1/18 , Y10S435/911 , Y10S435/968
摘要： Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.
摘要翻译： 提供了用于鉴定涉及使用膜电位指示剂染料的抗微生物剂的新型筛选方法。
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公开(公告)号：US06376211B1
公开(公告)日：2002-04-23
申请号：US09545112
申请日：2000-04-06
IPC分类号： C12Q142
CPC分类号： C12Q1/34 , C12Q1/18 , G01N2333/916
摘要： Novel methods of identifying antimicrobial and anti-proliferative agents and therapeutic uses are provided.
摘要翻译： 提供了鉴定抗微生物和抗增殖剂和治疗用途的新方法。
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公开(公告)号：US07045500B2
公开(公告)日：2006-05-16
申请号：US10319786
申请日：2002-12-13
申请人： Roger G. Little, II
发明人： Roger G. Little, II
IPC分类号： C07K14/00
CPC分类号： A61K38/1751 , C07K14/4742
摘要： The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
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公开(公告)号：US06664231B1
公开(公告)日：2003-12-16
申请号：US09677664
申请日：2000-10-02
IPC分类号： A61K3800
CPC分类号： A61K38/1751 , C07K14/4742
摘要： The present invention relates generally to anti-fungal peptides derived from or based on Domain III (amino acids 142-169) of bactericidal/permeability-increasing protein (BPI) and in vivo or in vitro uses of such peptides.
摘要翻译： 本发明一般涉及衍生自或基于杀菌/通透性增加蛋白（BPI）的领域III（氨基酸142-169）和这种肽的体内或体外应用的抗真菌肽。
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公开(公告)号：US6054431A
公开(公告)日：2000-04-25
申请号：US119263
申请日：1998-07-20
IPC分类号： C12N15/09 , A01N37/18 , A61K31/70 , A61K38/00 , A61K38/17 , A61K45/06 , A61P3/00 , A61P31/04 , C07H21/04 , C07K14/47 , C12P21/02 , A61K31/43 , C07K1/00
CPC分类号： C07K14/4742 , A61K38/00
摘要： The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
摘要翻译： 本发明涉及通过单独施用BPI蛋白质产品或与抗生素组合来治疗革兰氏阳性细菌感染的方法。 单独的BPI蛋白质产物对选择的革兰氏阳性生物体具有杀菌或生长抑制作用。 BPI蛋白质产品也增加了革兰氏阳性生物对抗生素的敏感性，甚至可以逆转革兰氏阳性生物对抗生素的抵抗力。
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7.发明授权Therapeutic uses of bactericidal/permeability increasing protein (BPI) protein products 失效杀菌/渗透性增加蛋白（BPI）蛋白产品的治疗用途
公开(公告)号：US5807818A
公开(公告)日：1998-09-15
申请号：US435855
申请日：1995-05-05
申请人： Roger G. Little, II
发明人： Roger G. Little, II
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P7/04 , A61P9/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/47 , C12P21/02 , A61K38/02 , A61K38/16
CPC分类号： C07K14/4742 , A61K38/1751
摘要： The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
摘要翻译： 本发明提供治疗包括中和肝素抗凝血活性，抑制血管生成，肿瘤和内皮细胞增殖以及通过施用杀菌/渗透性增加（BPI）蛋白治疗慢性炎性疾病的病症的治疗方法 产品。
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8.发明授权
公开(公告)号：US5348942A
公开(公告)日：1994-09-20
申请号：US30644
申请日：1993-03-12
CPC分类号： C07K14/4742 , A61K38/1751
摘要： The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
摘要翻译： 本发明提供治疗包括中和肝素抗凝血活性，抑制血管生成，肿瘤和内皮细胞增殖以及通过施用杀菌/渗透性增加（BPI）蛋白治疗慢性炎性疾病的病症的治疗方法 产品。
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9.发明授权Identification of novel antimicrobial agents using metabolic oxidation-reduction indicator dyes 失效使用代谢氧化还原指示剂染料鉴定新型抗微生物剂公开(公告)号：US06436660B1
公开(公告)日：2002-08-20
申请号：US09543955
申请日：2000-04-06
申请人： Roger G. Little, II
发明人： Roger G. Little, II
IPC分类号： C12Q118
CPC分类号： C12Q1/18 , C12Q1/26 , C12Q2326/92 , G01N2333/195 , G01N2333/37 , Y10S435/968
摘要： Novel screening methods for identifying antimicrobial agents involving use of metabolic oxidation-reduction indicator dyes are provided.
摘要翻译： 提供了用于鉴定涉及使用代谢氧化还原指示剂染料的抗微生物剂的新型筛选方法。
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10.发明授权Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof 失效来自杀菌/渗透性增加蛋白质的功能结构域的生物活性肽及其用途公开(公告)号：US06228834B1
公开(公告)日：2001-05-08
申请号：US09093539
申请日：1998-06-08
申请人： Roger G. Little, II
发明人： Roger G. Little, II
IPC分类号： C07K1400
CPC分类号： A61K38/1751 , C07K14/4742
摘要： The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
摘要翻译： 本发明提供具有氨基酸序列的氨基酸序列，该氨基酸序列是人类杀菌/增殖蛋白（BPI）功能结构域或其子序列的氨基酸序列，其序列或其子序列的变体具有至少一个 BPI生物活性，如肝素结合，肝素中和，LPS结合，LPS中和或杀菌活性。 本发明提供了用于各种治疗用途的这些肽的肽和药物组合物。
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