公开(公告)号：US4237275A

公开(公告)日：1980-12-02

申请号：US42828

申请日：1979-05-29

申请人： Rolf Bader ,  Dieter Reinehr

发明人： Rolf Bader ,  Dieter Reinehr

IPC分类号： C07D213/38 ,  C07D213/48 ,  C07D213/53 ,  C09B26/02 ,  C09B55/00

CPC分类号： C07D213/53 ,  C07D213/38 ,  C07D213/48 ,  C09B26/02

摘要： An improved process for producing pyridinaldehydes and hydrazone derivatives thereof, for example, pyridinaldehyde-phenylhydrazones, is described. This comprises reacting a aminomethylpyridine with an aldehyde or a ketone to give a compound of the formula ##STR1## isomerizing the compound (III), in the presence of suitable catalysts, to a compound of the formula ##STR2## and converting the compound (V), in the presence of an acid and optionally in the presence of a hydrazine, into a pyridinaldehyde or a pyridinaldehyde-hydrazone. It is possible to produce by the process according to the invention pyridinaldehydes and pyridinaldehyde-hydrazones in a simple manner, under mild ecologically favorable conditions and in good to very good yields.

摘要翻译： 描述了用于制备吡啶酮及其腙衍生物的改进方法，例如吡啶酮醛 - 苯腙。 这包括使氨基甲基吡啶与醛或酮反应，得到下式的化合物（III）; 在合适的催化剂存在下将化合物（III）异构化为式（V）化合物; 和在酸的存在下和任选地在肼的存在下将化合物（V）转化成吡啶甲醛或吡哆醛 - 腙。 根据本发明的方法，可以在温和的生态有利条件下以良好至非常好的产率，以简单的方式生产吡哆醛和吡哆醛 - 腙。

公开(公告)号：US4322536A

公开(公告)日：1982-03-30

申请号：US164459

申请日：1980-06-30

申请人： Rolf Bader ,  Dieter Reinehr

发明人： Rolf Bader ,  Dieter Reinehr

IPC分类号： C07D213/38 ,  C07D213/48 ,  C07D213/53 ,  C09B26/02 ,  C09B55/00

CPC分类号： C07D213/53 ,  C07D213/38 ,  C07D213/48 ,  C09B26/02

摘要： A new improved process for producing pyridinaldehydes and hydrazone derivatives thereof, for example, pyridinaldehyde-phenylhydrazones, is described. This comprises reacting an aminomethylpyridine with an aldehyde or a ketone to give a compound of the formula ##STR1## isomerizing the compound (III), in the presence of suitable catalysts, to a compound of the formula ##STR2## and converting the compound (V), in the presence of an acid and optionally in the presence of a hydrazine, into a pyridinaldehyde or a pyridinaldehyde-hydrazone. It is possible to produce by the process according to the invention pyridinaldehydes and pyridinaldehyde-hydrazones in a simple manner, under mild ecologically favorable conditions and in good to very good yields.

摘要翻译： 描述了一种新的改进的吡啶醛和腙衍生物的制备方法，例如吡啶酮醛 - 苯腙。 这包括使氨基甲基吡啶与醛或酮反应，得到在合适的催化剂存在下将化合物（III）异构化的式（III）化合物转化为式（V）化合物， 和在酸的存在下和任选地在肼的存在下将化合物（V）转化成吡啶甲醛或吡哆醛 - 腙。 根据本发明的方法，可以在温和的生态有利条件下以良好至非常好的产率，以简单的方式生产吡哆醛和吡哆醛 - 腙。

公开(公告)号：US4220788A

公开(公告)日：1980-09-02

申请号：US932730

申请日：1978-08-10

申请人： Rolf Bader ,  Leopold Kung ,  Peter Waldvogel

发明人： Rolf Bader ,  Leopold Kung ,  Peter Waldvogel

IPC分类号： C07D249/20

CPC分类号： C07D249/20

摘要： A process for producing benzotriazoles of the formula I ##STR1## wherein R.sub.1 is hydrogen or chlorine,R.sub.2 is hydrogen, chlorine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.9 alkoxycarbonyl, carboxyl or sulfo,R.sub.3 is C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.4 alkoxy, phenyl, (C.sub.1 -C.sub.8 alkyl)-phenyl, C.sub.5 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.9 alkoxycarbonyl, chlorine, carboxyethyl or C.sub.7 -C.sub.9 phenylalkyl,R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, chlorine or hydroxyl, andR.sub.5 is hydrogen, C.sub.1 -C.sub.12 alkyl, chlorine, C.sub.5 -C.sub.6 cycloalkyl or C.sub.7 -C.sub.9 phenylalkyl,which process comprises treating a benzotriazole-N-oxide of the formula II ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 have the above meanings, at a temperature of 20.degree.-150.degree. C., with an amine; or treating an o-nitroazobenzene of the formula III ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 have the above meanings, at a temperature of 20.degree.-150.degree. C., with an amine.

摘要翻译： 制备式I的苯并三唑的方法其中R1是氢或氯，R2是氢，氯，C1-C4烷基，C1-C4烷氧基，C2-C9烷氧基羰基，羧基或磺基，R3是C1 -C 12烷基，C 1 -C 4烷氧基，苯基，（C 1 -C 8烷基） - 苯基，C 5 -C 6环烷基，C 2 -C 9烷氧基羰基，氯，羧乙基或C 7 -C 9苯基烷基，R 4是氢，C 1 -C 4烷基， C4烷氧基，氯或羟基，R5是氢，C1-C12烷基，氯，C5-C6环烷基或C7-C9苯基烷基，该方法包括处理式II的苯并三唑-N-氧化物其中 R 1，R 2，R 3，R 4和R 5在20〜150℃的温度下具有上述含义; 或者在20-150℃下用胺处理其中R 1，R 2，R 3，R 4和R 5具有上述含义的式III的邻硝基偶氮（III）。

公开(公告)号：US5430188A

公开(公告)日：1995-07-04

申请号：US168034

申请日：1993-12-15

申请人： Rolf Bader ,  Peter Flatt ,  Paul Radimerski

发明人： Rolf Bader ,  Peter Flatt ,  Paul Radimerski

IPC分类号： B01J27/02 ,  A01N33/00 ,  C07B61/00 ,  C07C209/26 ,  C07C211/00 ,  C07C211/46 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C217/76 ,  C07C231/00 ,  C07C231/02 ,  C07C233/18 ,  C07C231/08

CPC分类号： C07C231/02 ,  C07C209/26 ,  C07C213/02

摘要： A process for the preparation of 2-alkyl-6-methyl-N(1'-methoxy-2'-propyl)-aniline by catalytic reductive alkylation wherein at least one mole equivalent of methoxyacetone is reacted with one mole equivalent of 2-alkyl-6-methyl-aniline in a liquid medium without an additional solvent, in the presence of a platinized carbon catalyst and hydrogen and in the presence of an acid cocatalyst under a hydrogen pressure of between 2.times.10.sup.5 and 1.times.10.sup.6 Pa at a temperature between 20.degree. and 80.degree. C., characterized in that the reaction mixture contains water from the beginning of the reaction and after the hydrogenation, base is added, the reaction mixture is filtered to separate the catalyst and the title compound recovered from the filtrate. The process is particularly useful for the preparation of N-substituted chloracetanilide herbicides.

摘要翻译： 通过催化还原烷基化制备2-烷基-6-甲基-N（1'-甲氧基-2'-丙基） - 苯胺的方法，其中至少一摩尔当量的甲氧基丙酮与1摩尔当量的2-烷基 -6-甲基 - 苯胺在没有另外的溶剂的液体介质中，在镀铂的碳催化剂和氢的存在下，在酸性助催化剂存在下，在2×10 5和1×10 6 Pa之间的氢气压力下，在20〜 其特征在于，反应混合物从反应开始起含有水，加氢后加入碱，将反应混合物过滤分离出催化剂和从滤液中回收的标题化合物。 该方法特别适用于制备N-取代的氯乙酰苯胺除草剂。

公开(公告)号：US5116518A

公开(公告)日：1992-05-26

申请号：US621644

申请日：1990-12-03

申请人： Wilfried Bachmann ,  Rolf Bader ,  Horst Buttner ,  Edgar Wetzel

发明人： Wilfried Bachmann ,  Rolf Bader ,  Horst Buttner ,  Edgar Wetzel

IPC分类号： C07C67/52 ,  C07C69/82

CPC分类号： C07C67/52

摘要： In the process for the purification of diemthyl terephthalate (DMT) by recrystallization from methanolic solution, the mother liquor containing the impurities, substantially the isomers DMI, DMO and aldehydes, is separated off and passed to a workup tank. The moist crystals are dried by melting with the evaporation of methanol. The mother liquor is then separated off by filtration, and the moist crystals obtained from the separation are washed before melting. The washing liquid is recycled together with a portion of the separated mother liquor into the recrystallization tank.

摘要翻译： 在通过从甲醇溶液中重结晶纯化对苯二甲酸二甲酯（DMT）的方法中，将含有杂质（基本上为异构体DMI，DMO和醛）的母液分离出并通入处理池。 潮湿的晶体通过用甲醇蒸发而熔化而干燥。 然后通过过滤分离母液，并将从分离得到的潮湿晶体在熔融之前洗涤。 洗涤液与一部分分离的母液一起再循环到再结晶槽中。

公开(公告)号：US4683034A

公开(公告)日：1987-07-28

申请号：US766767

申请日：1985-08-16

申请人： Rolf Bader ,  Hartmut Last ,  Manfred Mayer ,  Siegbert Rittner ,  Edgar Wetzel

发明人： Rolf Bader ,  Hartmut Last ,  Manfred Mayer ,  Siegbert Rittner ,  Edgar Wetzel

IPC分类号： C07C67/52 ,  C07C69/80 ,  B01D9/00

CPC分类号： C07C67/52 ,  C07C67/54

摘要： The invention relates to a process for separating dimethyl isophthalate (DMI) and dimethyl orthophthalate (DMO) and other by-products from their mixture with dimethyl terephthalate (DMT), formed in the oxidation of p-xylene followed by esterification with methanol, by crystallization from the melt.Initially, the esterification product is here distilled once or several times. The DMT-rich fraction obtained is then subjected wholly or partially to one or several crystallizations from the melt, and the DMI-DMO fraction thus obtained is at least partially removed from the system. As an alternative, the DMT-rich fraction is first recrystallized from methanol, the methanol is then evaporated from the mother liquor and the remaining residue is subjected to one or several crystallizations from the melt. The DMI-DMO fraction thus obtained is again at least partially removed from the system.

摘要翻译： 本发明涉及一种分离二甲基间苯二甲酸二甲酯（DMI）和邻苯二甲酸二甲酯（DMO）等副产物与其对苯二甲酸二甲酯（DMT）的混合物，在对二甲苯的氧化中形成，然后用甲醇酯化，通过结晶 从熔化。 最初，酯化产物在此蒸馏一次或几次。 然后将获得的富含DMT的级分全部或部分地从熔体中进行一次或多次结晶，并且由此获得的DMI-DMO级分至少部分地从体系中除去。 作为替代方案，富含DMT的级分首先从甲醇中重结晶，然后从母液中蒸发甲醇，剩余的残余物经受来自熔体的一种或多种结晶。 这样获得的DMI-DMO馏分再次至少部分地从系统中除去。