公开(公告)号：US20110092517A1

公开(公告)日：2011-04-21

申请号：US12856532

申请日：2010-08-13

申请人： Ronald Barbaras ,  Daniela Carmen Oniciu ,  Jean-Louis H. Dasseux ,  Robert A. Scott ,  John R. Wetterau

发明人： Ronald Barbaras ,  Daniela Carmen Oniciu ,  Jean-Louis H. Dasseux ,  Robert A. Scott ,  John R. Wetterau

IPC分类号： A61K31/496 ,  A61P11/00 ,  A61P11/06 ,  A61P29/00 ,  A61P9/10 ,  A61P19/02 ,  A61P3/10 ,  A61P3/04 ,  A61P5/50 ,  A61P9/12 ,  A61P3/06 ,  A61P21/00 ,  A61P25/08 ,  A61P17/14 ,  A61K31/426 ,  A61K31/423 ,  A61P17/02 ,  A61K31/421 ,  A61K31/4164 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/415 ,  A61K31/381

CPC分类号： A61K31/381 ,  A61K31/382 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426

摘要： Provided herein are methods for treatment, prevention, or amelioration of one or more symptoms of a disease or condition related to disorders of insulin and/or glucose metabolism, inflammatory conditions, mitochondrial disease, muscle disorders, or pulmonary disorders, involving administering a PPARδ agonist or a pharmaceutical composition comprising a PPARδ agonist. In one embodiment, the disease or condition is selected from myopathy, inflammatory vascular diseases, Parkinson's and Alzheimer's diseases, systemic inflammatory disorders, renal ischemia, inflammatory rheumatic disorders, and inflammatory diseases of the lung. In another embodiment, methods for increasing oxidative muscle fibers, reducing mitochondria disease, decreasing insulin resistance, decreasing plasma glucose, or decreasing weight, involving administering a PPARδ agonist or a pharmaceutical composition comprising a PPARδ agonist, are provided.

摘要翻译： 本文提供了治疗，预防或改善与胰岛素和/或葡萄糖代谢紊乱，炎性病症，线粒体疾病，肌肉病症或肺部疾病相关的疾病或病症的一种或多种症状的方法，包括施用PPARδ激动剂 或包含PPARδ激动剂的药物组合物。 在一个实施方案中，疾病或病症选自肌病，炎性血管疾病，帕金森病和阿尔茨海默病，全身性炎性疾病，肾缺血，炎性风湿病和肺炎性疾病。 在另一个实施方案中，提供了包括施用PPARδ激动剂或包含PPARδ激动剂的药物组合物的用于增加氧化性肌纤维，减少线粒体疾病，降低胰岛素抵抗，降低血浆葡萄糖或降低体重的方法。

公开(公告)号：US20100015220A1

公开(公告)日：2010-01-21

申请号：US12469653

申请日：2009-05-20

申请人： John R. WETTERAU ,  Lingyu Zhu ,  Robert A. Scott ,  Constance H. Keyserling ,  Jean-Louis H. Dasseux ,  Daniela Carmen Oniciu ,  Pierre Autant ,  Roger Kravtzoff ,  Catherine Castan ,  Hervé Guillard

发明人： John R. WETTERAU ,  Lingyu Zhu ,  Robert A. Scott ,  Constance H. Keyserling ,  Jean-Louis H. Dasseux ,  Daniela Carmen Oniciu ,  Pierre Autant ,  Roger Kravtzoff ,  Catherine Castan ,  Hervé Guillard

IPC分类号： A61K9/48 ,  A61K9/20 ,  A61K31/455 ,  A61K9/50 ,  A61K31/60 ,  A61P25/34

CPC分类号： A61K31/455 ,  A61K31/616 ,  A61K2300/00

摘要： Provided are pharmaceutical compositions and methods for preventing or reducing niacin-induced flushing comprising an aspirin component and a niacin component having different release profiles. Also provided are methods and compositions for preventing or reducing niacin-induced flushing comprising niacin, aspirin and a lipid-lowering drug other than niacin.

摘要翻译： 提供了用于预防或减少烟酸诱发的潮红的药物组合物和方法，其包含具有不同释放特征的阿司匹林组分和烟酸组分。 还提供了用于预防或减少烟酸诱发的潮红的方法和组合物，其包含烟酸，阿司匹林和除了烟酸以外的降脂药物。

公开(公告)号：US06974702B2

公开(公告)日：2005-12-13

申请号：US10657810

申请日：2003-09-08

申请人： Jean-Louis H. Dasseux ,  Roger S. Newton ,  Thomas J. Rea ,  Charles L. Bisgaier ,  Michael E. Pape

发明人： Jean-Louis H. Dasseux ,  Roger S. Newton ,  Thomas J. Rea ,  Charles L. Bisgaier ,  Michael E. Pape

IPC分类号： G01N27/62 ,  C12Q1/08 ,  G01N33/00 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5038 ,  G01N33/5091 ,  Y02A90/26 ,  Y10T436/24

摘要： The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).

公开(公告)号：US06680203B2

公开(公告)日：2004-01-20

申请号：US09735707

申请日：2000-12-12

申请人： Jean-Louis H. Dasseux ,  Roger S. Newton ,  Thomas J. Rea ,  Charles L. Bisgaier ,  Michael E. Pape

发明人： Jean-Louis H. Dasseux ,  Roger S. Newton ,  Thomas J. Rea ,  Charles L. Bisgaier ,  Michael E. Pape

IPC分类号： G01N3300

CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5038 ,  G01N33/5091 ,  Y02A90/26 ,  Y10T436/24

摘要： The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).

摘要翻译： 本发明涉及使用傅里叶变换质谱（FTMS）的复杂生物系统的高信息含量（HIC）分析或筛选方法。 本方法可用于分析含有高分子量分子（例如多核苷酸，蛋白质，多糖）和低分子量分子（例如寡核苷酸，肽，脂质，寡糖，类固醇激素，分解代谢和代谢中间体）的复杂生物混合物 澄清复杂生物样品之间的分子差异，并允许鉴定生物活性分子（例如治疗活性药物等）。

公开(公告)号：US20130289117A1

公开(公告)日：2013-10-31

申请号：US13925818

申请日：2013-06-24

申请人： Jean-Louis H. Dasseux ,  Carmen Daniela Oniciu

发明人： Jean-Louis H. Dasseux ,  Carmen Daniela Oniciu

IPC分类号： C07C59/245

CPC分类号： C07C31/27 ,  A61K31/191 ,  A61K31/194 ,  A61K31/20 ,  A61K31/23 ,  C07C31/20 ,  C07C31/22 ,  C07C31/24 ,  C07C33/26 ,  C07C47/19 ,  C07C47/34 ,  C07C59/01 ,  C07C59/105 ,  C07C59/11 ,  C07C59/245 ,  C07C59/285 ,  C07C59/29 ,  C07C59/46 ,  C07C59/48 ,  C07C59/54 ,  C07C61/12 ,  C07C62/02 ,  C07C62/06 ,  C07C65/17 ,  C07C69/003 ,  C07C69/017 ,  C07C69/675 ,  C07C69/757 ,  C07C255/00 ,  C07C309/08 ,  C07C309/24 ,  C07C309/25 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D213/80 ,  C07D257/04 ,  C07D261/08 ,  C07D261/12 ,  C07D305/12 ,  C07D307/33 ,  C07D309/10 ,  C07D309/12 ,  C07D309/30 ,  C07D405/12 ,  C07D495/04 ,  C07F9/093 ,  C07F9/094 ,  C07F9/11 ,  C07F9/117 ,  C07F9/12 ,  C07F9/2408 ,  C07F9/2416 ,  C07F9/242 ,  C07F9/2425 ,  C07F9/4423

摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.