公开(公告)号：US5776713A

公开(公告)日：1998-07-07

申请号：US291200

申请日：1994-08-16

申请人： Ronald Colin Garner ,  David J. Phillips ,  Timothy G. Wilkinson ,  Frank G. Angella ,  Erwin R. Dorland ,  Martin W. Stow

发明人： Ronald Colin Garner ,  David J. Phillips ,  Timothy G. Wilkinson ,  Frank G. Angella ,  Erwin R. Dorland ,  Martin W. Stow

IPC分类号： G01N33/53 ,  G01N33/545

CPC分类号： G01N33/2882 ,  G01N33/5308 ,  Y10S436/822

摘要： In general, the invention features a method of marking a product for identification in which a marker, composed of a low molecular weight hapten covalently bound to a compound, is associated with the product. Where the marker is non-deleterious to the product, inert with respect to the product, and not already associated with the product. The invention also features hapten markers produced by covalently binding a hapten to a functional monomer and subsequently polymerizing the hapten-labeled monomer to form a hapten-labeled polymer.

摘要翻译： 通常，本发明的特征在于一种标记产品鉴定的方法，其中由与化合物共价结合的低分子量半抗原组成的标记与产物相关联。 当标记对产品无害时，对于产品是惰性的，并且不与产品相关。 本发明还具有通过将半抗原与功能性单体共价结合而产生的半抗原标记，随后聚合半抗原标记的单体以形成半抗原标记的聚合物。

公开(公告)号：US6068981A

公开(公告)日：2000-05-30

申请号：US943639

申请日：1997-10-03

申请人： James H. Rittenburg ,  Frank G. Angella ,  Michael G. Pappas

发明人： James H. Rittenburg ,  Frank G. Angella ,  Michael G. Pappas

IPC分类号： A61K9/22 ,  G01N33/53 ,  A61K49/00 ,  G01N33/48

CPC分类号： G01N33/5308 ,  Y10S436/822 ,  Y10S514/811 ,  Y10S514/812 ,  Y10S514/964 ,  Y10T436/13

摘要： A method of monitoring a therapeutic regimen in an animal, the method involving a) providing to the animal a therapeutic compound and a detectable compound that passes into the bloodstream, excretory system, or other tissue or body fluid in detectable form; b) after a period of time, following step (a), sufficient for passage of a detectable amount of the detectable compound into the body fluid or tissue, collecting a sample of the fluid or tissue from the animal; and c) measuring or detecting the detectable compound, or a detectable metabolite thereof, in the sample, wherein the detectable compound involves one member of a specific binding pair, and detection is carried out using the second member of the specific binding pair.

摘要翻译： 一种监测动物中治疗方案的方法，所述方法包括：a）向动物提供治疗化合物和可检测化合物，其以可检测的形式进入血流，排泄系统或其他组织或体液; b）在步骤（a）之后一段时间后，足以使可检测量的可检测化合物通过体液或组织，从动物收集流体或组织的样品; 和c）测量或检测样品中可检测化合物或其可检测的代谢物，其中可检测化合物涉及特异性结合对的一个成员，并且使用特异性结合对的第二个成员进行检测。