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公开(公告)号：US5374242A
公开(公告)日：1994-12-20
申请号：US164663
申请日：1993-12-07
CPC分类号： A61N1/30
摘要： An iontophoretic drug-delivery device incorporating a power supply which minimizes the cost of the batteries needed by operating the batteries in a series configuration at the start of delivery, when the patient's skin resistance is high, and by switching the batteries into a parallel configuration when skin resistance drops. An automatic switching circuit for achieving this transition is included.
摘要翻译： 一种离子电渗药物输送装置，其包含电源，其在患者开始输送时，当患者的皮肤电阻高时将串联配置中的电池操作所需的电池成本最小化，并且通过将电池切换成并行配置， 皮肤阻力下降。 包括用于实现该转换的自动切换电路。
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2.发明授权Electrotransport delivery device having improved safety and reduced abuse potential 失效电传输装置具有改进的安全性和降低的滥用潜力公开(公告)号：US07027859B1
公开(公告)日：2006-04-11
申请号：US08312336
申请日：1994-09-26
申请人： Larry A. McNichols , John D. Badzinski , William N. Reining , Gary A. Lattin , Ronald P Haak , Joseph B. Phipps
发明人： Larry A. McNichols , John D. Badzinski , William N. Reining , Gary A. Lattin , Ronald P Haak , Joseph B. Phipps
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device (20) for delivering one or more therapeutic agents through the skin includes electrodes (30,32) for contacting the skin (34), at least one electrode containing the agent, a power source (22) for generating electrical current (IL) for delivering the agent, a current generating and controlling means (24), and a disabling means (26) for permanently and irreversibly disabling the current. The disabling means (26) may include a timer means (66), a counter means (82), or a body parameter sensor (134) and limit comparator (132) to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source (22), or a permanent diversion of electrotransport current from the electrodes (30,32), or a combination of the above. The permanent disabling means may include a circuit connection means (304,308,326,328) having a frangible conducting member (332) which permanently fractures and causes an irreversible open circuit in the connection to the electrodes (334,342) upon removing a disposable/single use electrode assembly (300) from a reusable portion of an electrotransport device.
摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置（20）包括用于接触皮肤（34）的电极（30,32），包含该药剂的至少一个电极，用于产生电流的电源（22） 用于传送代理，电流产生和控制装置（24）以及用于永久地且不可逆地禁用电流的禁用装置（26）。 禁用装置（26）可以包括定时器装置（66），计数装置（82）或身体参数传感器（134）和限制比较器（132）以实现永久禁用。 禁用装置可以是永久地转换到禁用的逻辑状态，电源的永久放电（22），或者电极（30,32）的永久转移或电转移电流的永久转移，或上述的组合。 永久禁用装置可以包括电路连接装置（304,308,326,328），该电路连接装置具有易失性的导电构件（332），其在移除一次性/单次使用的电极组件（300）后永久地断裂并且在与电极（334,342）的连接中引起不可逆的开路 ）从电输送装置的可重复使用的部分。
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公开(公告)号：US6090095A
公开(公告)日：2000-07-18
申请号：US881529
申请日：1997-06-24
IPC分类号： A61N1/30
CPC分类号： A61N1/0412 , A61N1/0428 , A61N1/303
摘要： An electrotransport delivery device (410) includes control circuitry for discontinuously delivering a beneficial agent (eg, a drug) through a body surface (eg, skin 400). For example, the device may be the type which is manually activated by the patient or other medical personnel to activate electrotransport drug delivery. Once electrotransport delivery has been activated, a timer (221) counts a transition interval, typically about one minute, during which the device is allowed to operate and the impedance of the body surface (400) is allowed to stabilize. Thereafter, the electrotransport current and voltage are then monitored and compared to predetermined limits. Allowing for the transition interval permits tighter tolerances in monitoring the applied current.
摘要翻译： 电输送装置（410）包括控制电路，用于通过身体表面（例如，皮肤400）不连续地递送有益药剂（例如药物）。 例如，该装置可以是由患者或其他医务人员手动激活以激活电转运药物递送的类型。 一旦电运输递送已被激活，计时器（221）计数通常约1分钟的过渡间隔，在该过程间隔期间该装置被允许操作并允许体表（400）的阻抗稳定。 此后，监测电输送电流和电压，并将其与预定限度进行比较。 允许过渡间隔允许更严格的监测施加电流的公差。
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公开(公告)号：US5697896A
公开(公告)日：1997-12-16
申请号：US353036
申请日：1994-12-08
IPC分类号： A61N1/30
CPC分类号： A61N1/0412 , A61N1/0428 , A61N1/303
摘要： An electrotransport delivery device (410) includes control circuitry for discontinuously delivering a beneficial agent (eg, a drug) through a body surface (eg, skin 400). For example, the device may be the type which is manually activated by the patient or other medical personnel to activate electrotransport drug delivery. Once electrotransport delivery has been activated, a timer (221) counts a transition interval, typically about one minute, during which the device is allowed to operate and the impedance of the body surface (400) is allowed to stabilize. Thereafter, the electrotransport current and voltage are then monitored and compared to predetermined limits. Allowing for the transition interval permits tighter tolerances in monitoring the applied current.
摘要翻译： 电输送装置（410）包括控制电路，用于通过身体表面（例如，皮肤400）不连续地递送有益药剂（例如药物）。 例如，该装置可以是由患者或其他医务人员手动激活以激活电转运药物递送的类型。 一旦电运输递送已被激活，计时器（221）计数通常约1分钟的过渡间隔，在该过程间隔期间该装置被允许操作并允许体表（400）的阻抗稳定。 此后，监测电输送电流和电压，并将其与预定限度进行比较。 允许过渡间隔允许更严格的监测施加电流的公差。
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5.发明申请Electrotransport Delivery Device Having Improved Safety and Reduced Abuse Potential 审中-公开电子输送装置具有改进的安全性和减少的滥用潜力公开(公告)号：US20100076368A1
公开(公告)日：2010-03-25
申请号：US12627230
申请日：2009-11-30
申请人： Larry A. McNichols , John D. Badzinski , William N. Reining , Gary A. Lattin , Ronald P. Haak , Joseph B. Phipps
发明人： Larry A. McNichols , John D. Badzinski , William N. Reining , Gary A. Lattin , Ronald P. Haak , Joseph B. Phipps
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.
摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。
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6.发明授权Electrotransport delivery device having improved safety and reduced abuse potential 失效电传输装置具有改进的安全性和降低的滥用潜力公开(公告)号：US07660627B2
公开(公告)日：2010-02-09
申请号：US11334001
申请日：2006-01-18
申请人： Larry A. McNichols , Joseph B. Phipps , Gary A. Lattin , John D. Badzinski , Wiliam N. Reining , Ronald P. Haak
发明人： Larry A. McNichols , Joseph B. Phipps , Gary A. Lattin , John D. Badzinski , Wiliam N. Reining , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.
摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。
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公开(公告)号：US6035234A
公开(公告)日：2000-03-07
申请号：US939921
申请日：1997-09-29
CPC分类号： A61N1/044 , A61N1/30 , A61N1/325 , A61N1/0448
摘要： An electrotransport device (10) for delivering therapeutic agents includes an adjustable voltage boost multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage V.sub.w having a value just sufficient to provide the desired therapeutic current level I.sub.I through the electrodes (108, 112), at least one of which contains the therapeutic agent to be delivered.
摘要翻译： 用于递送治疗剂的电输送装置（10）包括用于将来自电源（102,202）的电压升压到具有刚好足以提供所需治疗剂的值的工作电压Vw的可调升压多重控制器（100,200） 电流水平II通过电极（108,112），其中至少一个含有待递送的治疗剂。
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公开(公告)号：US4458689A
公开(公告)日：1984-07-10
申请号：US415044
申请日：1982-09-03
CPC分类号： A61B8/4209 , A61B8/0875 , A61B8/4245 , G01S15/8938 , G01S7/5206 , G10K11/352
摘要： An ultrasound scanning system including an array of ultrasound transducers and a transporter for moving the transducers over a human back. The movement of the ultrasound transducers define a plane and a position transducer produces a position signal representative of the position of the ultrasound transducers in the plane. There is a means for producing a range signal representative of the distance between the transducers and the objects imaged in the back. The range signals are digitized and stored in an array in a digital memory with the position of each stored range signal in the array corresponding to the position of the transducer from which the range signal was obtained in the plane at the time the range signal was received. The range information is printed on a page or displayed on a cathode ray tube with the position of the printed data on the page or the data displayed on the cathode ray tube corresponding to the position on the plane of the back from which the data was obtained.
摘要翻译： 一种超声波扫描系统，包括超声换能器阵列和用于将换能器在人背上移动的运送器。 超声换能器的运动定义一个平面，位置传感器产生一个代表超声换能器在平面中的位置的位置信号。 存在用于产生表示换能器与在背面成像的物体之间的距离的范围信号的装置。 范围信号被数字化并存储在数字存储器中的阵列中，其中阵列中的每个存储的范围信号的位置对应于在接收到范围信号时从平面获得范围信号的换能器的位置 。 范围信息被打印在页面上或显示在阴极射线管上，其中印刷数据位于页面上，或显示在阴极射线管上的数据对应于从其获得数据的背面平面上的位置 。
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公开(公告)号：US07708731B2
公开(公告)日：2010-05-04
申请号：US10999504
申请日：2004-11-30
IPC分类号： A61M31/00
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device (10) for delivering therapeutic agents includes an adjustable voltage boos multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage Vw having a value just sufficient to provide the desired therapeutic current level II through the electrodes (108, 112), at least of which contains the therapeutic agent to be delivered.
摘要翻译： 用于递送治疗剂的电输送装置（10）包括用于将来自电源（102,202）的电压升高到具有刚好足以提供所需治疗剂的值的工作电压Vw的可调节电压波形多重控制器（100,200） 电流水平II通过电极（108,112），其至少包含待递送的治疗剂。
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公开(公告)号：US07054683B2
公开(公告)日：2006-05-30
申请号：US11214246
申请日：2005-08-29
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of the same reservoir configurations and drug formulations. A method of making a reservoir and a family of reservoirs and incorporating them into an electrotransport system is disclosed.
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