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    Electrotransport delivery device having improved safety and reduced abuse potential
    1.
    发明授权
    Electrotransport delivery device having improved safety and reduced abuse potential 失效
    电传输装置具有改进的安全性和降低的滥用潜力

    公开(公告)号：US07027859B1

    公开(公告)日：2006-04-11

    申请号：US08312336

    申请日：1994-09-26

    申请人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P Haak ,  Joseph B. Phipps

    发明人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P Haak ,  Joseph B. Phipps

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

    摘要： An electrotransport device (20) for delivering one or more therapeutic agents through the skin includes electrodes (30,32) for contacting the skin (34), at least one electrode containing the agent, a power source (22) for generating electrical current (IL) for delivering the agent, a current generating and controlling means (24), and a disabling means (26) for permanently and irreversibly disabling the current. The disabling means (26) may include a timer means (66), a counter means (82), or a body parameter sensor (134) and limit comparator (132) to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source (22), or a permanent diversion of electrotransport current from the electrodes (30,32), or a combination of the above. The permanent disabling means may include a circuit connection means (304,308,326,328) having a frangible conducting member (332) which permanently fractures and causes an irreversible open circuit in the connection to the electrodes (334,342) upon removing a disposable/single use electrode assembly (300) from a reusable portion of an electrotransport device.

    摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置（20）包括用于接触皮肤（34）的电极（30,32），包含该药剂的至少一个电极，用于产生电流的电源（22） 用于传送代理，电流产生和控制装置（24）以及用于永久地且不可逆地禁用电流的禁用装置（26）。 禁用装置（26）可以包括定时器装置（66），计数装置（82）或身体参数传感器（134）和限制比较器（132）以实现永久禁用。 禁用装置可以是永久地转换到禁用的逻辑状态，电源的永久放电（22），或者电极（30,32）的永久转移或电转移电流的永久转移，或上述的组合。 永久禁用装置可以包括电路连接装置（304,308,326,328），该电路连接装置具有易失性的导电构件（332），其在移除一次性/单次使用的电极组件（300）后永久地断裂并且在与电极（334,342）的连接中引起不可逆的开路 ）从电输送装置的可重复使用的部分。

    Electrotransport Delivery Device Having Improved Safety and Reduced Abuse Potential
    2.
    发明申请
    Electrotransport Delivery Device Having Improved Safety and Reduced Abuse Potential 审中-公开
    电子输送装置具有改进的安全性和减少的滥用潜力

    公开(公告)号：US20100076368A1

    公开(公告)日：2010-03-25

    申请号：US12627230

    申请日：2009-11-30

    申请人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

    发明人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

    摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

    摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

    Electrotransport delivery device having improved safety and reduced abuse potential
    3.
    发明授权
    Electrotransport delivery device having improved safety and reduced abuse potential 失效
    电传输装置具有改进的安全性和降低的滥用潜力

    公开(公告)号：US07660627B2

    公开(公告)日：2010-02-09

    申请号：US11334001

    申请日：2006-01-18

    申请人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

    发明人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

    摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

    摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

    Iontophoretic drug delivery system with two-stage delivery profile
    7.
    发明授权
    Iontophoretic drug delivery system with two-stage delivery profile 失效
    具有两级交付配置文件的IOPOPHORETIC DRUG DELIVERY SYSTEM

    公开(公告)号：US5207752A

    公开(公告)日：1993-05-04

    申请号：US671306

    申请日：1991-03-21

    申请人： Paul D. Sorenson ,  John D. Badzinski ,  Gary A. Lattin ,  Larry A. McNichols

    发明人： Paul D. Sorenson ,  John D. Badzinski ,  Gary A. Lattin ,  Larry A. McNichols

    IPC分类号： A61N1/30 ,  A61N1/32

    CPC分类号： A61N1/0428 ,  A61N1/325

    摘要： A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level to maintain a desired steady-state therapeutic level of the agent. One embodiment provides that the initial interval is maintained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief interval of increased iontophoretic current level to attain a brief interval of increased dosage.

    摘要翻译： 两阶段离子电渗药物递送系统提供离子电渗电流在第一水平上递送第一预定间隔，以将治疗剂快速引入血流中，然后还原至第二较低水平，以保持所需的稳态治疗水平 中介。 一个实施方案规定，初始间隔保持足够长以提供峰值剂量，之后电流被切断以允许试剂浓缩在血流中，从而启动离子电渗电流的维持水平。 另一个实施方案提供了患者可以选择性地启动增加的离子电渗电流水平的短暂间隔以获得增加剂量的短暂间隔。

    Electrotransport device and method of setting output
    9.
    发明授权
    Electrotransport device and method of setting output 失效
    电子输送设备和设置输出方法

    公开(公告)号：US6086572A

    公开(公告)日：2000-07-11

    申请号：US952656

    申请日：1998-03-09

    申请人： Susan A. Johnson ,  Gary A. Lattin ,  Larry A. McNichols

    发明人： Susan A. Johnson ,  Gary A. Lattin ,  Larry A. McNichols

    IPC分类号： A61N1/32 ,  A61M31/00

    CPC分类号： A61N1/0432 ,  A61N1/325 ,  A61N1/0436 ,  A61N1/044

    摘要： A two-part electrotransport drug delivery device (20) is comprised of a controller (22) which has a plurality of different electronic outputs. The controller (22) is adapted to be mechanically and electrically coupled to a plurality of different drug-containing units (24). Each drug unit (24) includes a means (40, 42, Rx, Cx) for signaling the controller (22). The signal is read by the controller (22) and a predetermined electronic output is thereby selected and applied through the drug unit (24) in order to deliver the drug contained therein by electrotransport. The signal sent by the drug unit (24) to the controller (22) may be an optical signal (e.g., reflected light), a signal sent by an electro-mechanical connector, an electrical signal (e.g., resistance or capacitance), a magnetic signal or a metal detector sensing signal.

    摘要翻译： PCT No.PCT / US96 / 08242 Sec。 371日期1998年3月9日 102（e）1998年3月9日PCT PCT 1996年5月31日PCT公布。 出版物WO96 / 38198 日期1996年12月5日两部分电传送药物输送装置（20）由具有多个不同电子输出的控制器（22）组成。 控制器（22）适于机械地和电耦合到多个不同的含药单元（24）。 每个药物单元（24）包括用于发信号通知控制器（22）的装置（40,42，Rx，Cx）。 该信号由控制器（22）读取，由此通过药物单元（24）选择并施加预定的电子输出，以通过电输送来输送其中所含的药物。 由药物单元（24）发送到控制器（22）的信号可以是光信号（例如，反射光），由机电连接器发送的信号，电信号（例如，电阻或电容）， 磁信号或金属检测器感测信号。

    Electrotransport agent delivery method and apparatus
    10.
    发明授权
    Electrotransport agent delivery method and apparatus 失效
    电子输送剂输送方法和装置

    公开(公告)号：US07212853B1

    公开(公告)日：2007-05-01

    申请号：US08952368

    申请日：1996-06-07

    申请人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    发明人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/044 ,  A61N1/0448

    摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.

    摘要翻译： 提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。 该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。 最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。