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1.
公开(公告)号:US08323646B2
公开(公告)日:2012-12-04
申请号:US12539630
申请日:2009-08-12
申请人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
发明人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要: The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译: 本发明涉及针对人白细胞介素-13(IL-13)蛋白或其片段免疫特异性的工程化抗体,以及其制备和使用方法,包括治疗适应症。
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2.
公开(公告)号:US08399630B2
公开(公告)日:2013-03-19
申请号:US13058453
申请日:2009-08-11
申请人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号: A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要: The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译: 本发明涉及针对人白细胞介素-13(IL-13)蛋白或其片段免疫特异性的工程化抗体,以及其制备和使用方法,包括治疗适应症。
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3.
公开(公告)号:US20120045438A1
公开(公告)日:2012-02-23
申请号:US13058453
申请日:2009-08-11
申请人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号: A61K39/395 , C12N15/13 , C12N15/63 , A61P11/06 , C12P21/00 , G01N33/566 , A61K39/00 , A61P37/04 , C12N5/10 , C12N1/19 , C12N1/21 , A61P31/00 , A61P9/00 , A61P25/00 , A61P11/00 , A61P1/00 , A61P7/00 , A61P37/02 , A61P35/00 , A61P3/12 , C07K16/24
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要: The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译: 本发明涉及针对人白细胞介素-13(IL-13)蛋白或其片段免疫特异性的工程化抗体,以及其制备和使用方法,包括治疗适应症。
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4.
公开(公告)号:US20100111959A1
公开(公告)日:2010-05-06
申请号:US12539630
申请日:2009-08-12
申请人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
发明人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要: The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译: 本发明涉及针对人白细胞介素-13(IL-13)蛋白或其片段免疫特异性的工程化抗体,以及其制备和使用方法,包括治疗适应症。
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公开(公告)号:US20130189250A1
公开(公告)日:2013-07-25
申请号:US13803887
申请日:2013-03-14
申请人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号: C07K16/46
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译: 本发明涉及能够预防组织因子(凝血因子F3)信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症,例如肿瘤进展。
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公开(公告)号:US20120237528A1
公开(公告)日:2012-09-20
申请号:US13398881
申请日:2012-02-17
申请人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号: A61K39/395 , C12N1/21 , C12N1/19 , C12N15/63 , C07K16/18 , C07H21/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P27/02 , A61P27/06 , A61P7/00 , A61P19/02 , A61P17/06 , A61P17/02 , A61P9/00 , A61P21/00 , A61P1/00 , A61P9/10 , C12N5/10
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译: 本发明涉及能够预防组织因子(凝血因子F3)信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症,例如肿瘤进展。
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公开(公告)号:US08722044B2
公开(公告)日:2014-05-13
申请号:US13398881
申请日:2012-02-17
申请人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号: A61K39/395 , C07K16/36 , C07K16/28 , A61K39/00
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译: 本发明涉及能够预防组织因子(凝血因子F3)信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症,例如肿瘤进展。
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