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公开(公告)号：US08323646B2
公开(公告)日：2012-12-04
申请号：US12539630
申请日：2009-08-12
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US08399630B2
公开(公告)日：2013-03-19
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US20120045438A1
公开(公告)日：2012-02-23
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P11/06 , C12P21/00 , G01N33/566 , A61K39/00 , A61P37/04 , C12N5/10 , C12N1/19 , C12N1/21 , A61P31/00 , A61P9/00 , A61P25/00 , A61P11/00 , A61P1/00 , A61P7/00 , A61P37/02 , A61P35/00 , A61P3/12 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US20100111959A1
公开(公告)日：2010-05-06
申请号：US12539630
申请日：2009-08-12
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US08580714B2
公开(公告)日：2013-11-12
申请号：US12904549
申请日：2010-10-14
IPC分类号： C40B10/00
CPC分类号： C07K16/00 , C07K16/248 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The invention relates to methods of affinity maturing antibodies.
摘要翻译： 本发明涉及亲和力成熟抗体的方法。
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公开(公告)号：US20100261620A1
公开(公告)日：2010-10-14
申请号：US12578803
申请日：2009-10-14
IPC分类号： C40B50/06
CPC分类号： C07K16/2803 , C07K16/244 , C07K16/461 , C07K2317/55 , C07K2317/56 , C07K2317/92
摘要： Methods of humanizing and affinity-maturing antibodies are disclosed.
摘要翻译： 公开了人源化和亲和力成熟抗体的方法。
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公开(公告)号：US08728985B2
公开(公告)日：2014-05-20
申请号：US13509292
申请日：2010-11-15
申请人： Chichi Huang , Tracy Spinka-Doms , Johan Fransson
发明人： Chichi Huang , Tracy Spinka-Doms , Johan Fransson
IPC分类号： C40B40/10
CPC分类号： C12N15/70 , C12N15/1037
摘要： Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention.
摘要翻译： 提供了用于在噬菌体颗粒的表面上显示复合同源二聚体蛋白的方法和显示为具有丝状噬菌体pIX外壳蛋白的融合多肽的这种蛋白质的组合合成文库。 可以使用本发明的方法显示异二聚体或更复杂的链间结合结构，例如二硫键连接的多聚体蛋白质。
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公开(公告)号：US20090285750A1
公开(公告)日：2009-11-19
申请号：US12296819
申请日：2007-04-11
申请人： Carl Borrebaeck , Johan Fransson
发明人： Carl Borrebaeck , Johan Fransson
IPC分类号： A61K51/10 , A61K38/00 , A61K31/7088 , A61K51/00 , A61K51/08 , A61P35/00 , G01N33/53 , C07H21/00 , C12N15/63 , C12N1/21 , C12N5/10 , C12P1/00
CPC分类号： C07K16/30 , A61K47/6809 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/77 , G01N33/57492
摘要： The present application relates to agents, compositions and methods for use in medicine. In particular, the application relates to an agent comprising a binding moiety capable of selectively binding to Ku protein for use in medicine, in particular in the treatment and diagnosis of cancers.
摘要翻译： 本申请涉及用于药物的药剂，组合物和方法。 特别地，本申请涉及包含能够选择性结合Ku蛋白的结合部分用于药物，特别是用于治疗和诊断癌症的药剂。
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9.发明申请公开(公告)号：US20120225085A1
公开(公告)日：2012-09-06
申请号：US13509292
申请日：2010-11-15
申请人： Chichi Huang , Tracy Spinka-Doms , Johan Fransson
发明人： Chichi Huang , Tracy Spinka-Doms , Johan Fransson
IPC分类号： A61K39/395 , C12N15/13 , C07K16/28 , C40B30/06 , C12N1/21 , C40B40/02 , C40B50/06 , C07K14/00 , C12N15/63
CPC分类号： C12N15/70 , C12N15/1037
摘要： Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention.
摘要翻译： 提供了用于在噬菌体颗粒的表面上显示复合同源二聚体蛋白的方法和显示为具有丝状噬菌体pIX外壳蛋白的融合多肽的这种蛋白质的组合合成文库。 可以使用本发明的方法显示异二聚体或更复杂的链间结合结构，例如二硫键连接的多聚体蛋白质。
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公开(公告)号：US20120093833A1
公开(公告)日：2012-04-19
申请号：US13269976
申请日：2011-10-10
IPC分类号： C07K16/24 , C12N15/13 , C12N5/10 , C12P21/02 , A61P19/02 , A61P17/06 , A61P11/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P19/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07H21/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
摘要翻译： 能够中和制瘤素M生物功能的抗体和组合物可用于治疗与制瘤素M相关的疾病和病症，例如骨关节炎和特发性肺纤维化。
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