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公开(公告)号：US20130280263A1
公开(公告)日：2013-10-24
申请号：US13798494
申请日：2013-03-13
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
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公开(公告)号：US08399630B2
公开(公告)日：2013-03-19
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US20120045438A1
公开(公告)日：2012-02-23
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P11/06 , C12P21/00 , G01N33/566 , A61K39/00 , A61P37/04 , C12N5/10 , C12N1/19 , C12N1/21 , A61P31/00 , A61P9/00 , A61P25/00 , A61P11/00 , A61P1/00 , A61P7/00 , A61P37/02 , A61P35/00 , A61P3/12 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译： 本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。
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公开(公告)号：US20110008352A1
公开(公告)日：2011-01-13
申请号：US12770147
申请日：2010-04-29
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： A61K39/395 , C07K16/28 , A61P29/00 , A61P19/02 , A61P37/02 , A61P11/06 , A61P11/00 , A61P31/12 , A61P31/16 , A61P1/04 , A61P3/10 , A61P3/00
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US5969105A
公开(公告)日：1999-10-19
申请号：US955848
申请日：1997-10-21
申请人： Yiqing Feng , Charles A. McWherter
发明人： Yiqing Feng , Charles A. McWherter
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/22 , A61K39/00 , A61K45/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K14/475 , C12N15/12 , C12P21/02 , C12P21/00 , A61K38/16 , C07H21/04 , C07K1/00
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention is drawn to human stem cell factor receptor agonist polypeptides, nucleic acid molecules encoding same, methods of producing the agonist polypeptides from the nucleic acid sequences and therapeutic compositions comprising the agonist polypeptides. The polypeptides of the instant invention are derived from the sequnce of SEQ ID NO:1, wherein 1-23 amino acids are optionally deleted from the C-terminus and the N-terminus is joined to the C-terminus, either directly or through a linker and C- and N-termini are created between an amino acid pair chosen from 23-24 through 110-111 of SEQ ID NO:1, generating said human stem cell factor receptor agonist polypeptide. The human stem cell factor receptor agonist polypeptide may additionally be immediately be preceded by a (methionine.sup.-1), (alanine.sup.-1) or (methionine.sup.-2, alanine.sup.-1).
摘要翻译： 本发明涉及人干细胞因子受体激动剂多肽，编码它们的核酸分子，从核酸序列产生激动剂多肽的方法和包含激动剂多肽的治疗组合物。 本发明的多肽衍生自SEQ ID NO：1的序列，其中1-23个氨基酸任选地从C末端缺失，并且N末端直接连接到C-末端，或通过 在选自SEQ ID NO：1的23-24至110-111的氨基酸对之间产生接头和C-和N-末端，产生所述人干细胞因子受体激动剂多肽。 人类干细胞因子受体激动剂多肽可以另外紧接在之前是（甲硫氨酸-1），（丙氨酸-1）或（甲硫氨酸-2，丙氨酸-1）。
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6.发明申请Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases 审中-公开Toll样受体3治疗代谢和心血管疾病的拮抗剂公开(公告)号：US20140017250A1
公开(公告)日：2014-01-16
申请号：US13887797
申请日：2013-05-06
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US06730303B1
公开(公告)日：2004-05-04
申请号：US09510238
申请日：2000-02-22
申请人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
发明人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
IPC分类号： C07K1900
CPC分类号： C07K14/5403 , A61K38/00 , A61K48/00 , A61K2035/124 , A61K2039/51 , C07K14/524 , C07K14/53 , C07K2319/00 , C07K2319/75 , C12N15/62
摘要： Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
摘要翻译： 公开了新型多功能造血受体激动剂蛋白质，编码多功能造血受体激动剂蛋白质的DNA，制备多功能造血受体激动剂蛋白质的方法和使用多功能造血受体激动剂蛋白质的方法。
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公开(公告)号：US09493489B2
公开(公告)日：2016-11-15
申请号：US13062450
申请日：2009-10-15
申请人： Robert Jacobs , Matthew Orr , Stephen Wring , Daitao Chen , Huchen Zhou , Dazhong Ding , Yiqing Feng , Long Yi , Vincent S. Hernandez , Yong-Kang Zhang , Jacob J. Plattner
发明人： Robert Jacobs , Matthew Orr , Stephen Wring , Daitao Chen , Huchen Zhou , Dazhong Ding , Yiqing Feng , Long Yi , Vincent S. Hernandez , Yong-Kang Zhang , Jacob J. Plattner
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US20140212426A1
公开(公告)日：2014-07-31
申请号：US13751718
申请日：2013-01-28
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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10.发明申请Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases 审中-公开Toll样受体3治疗代谢和心血管疾病的拮抗剂公开(公告)号：US20130090457A1
公开(公告)日：2013-04-11
申请号：US13628434
申请日：2012-09-27
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/28 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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