公开(公告)号：US20210033561A1

公开(公告)日：2021-02-04

申请号：US16684285

申请日：2019-11-14

Applicant: Rosemount Inc. ,  Regents of the University of Minnesota

Inventor： Xin Chen ,  Jinbo Hu ,  Philippe Buhlmann

IPC: G01N27/333 ,  B01D69/10 ,  B01D67/00 ,  B01D61/48 ,  B01D71/82 ,  B01D71/40

Abstract: An electrochemical sensor with an ion-selective membrane that comprises a crosslinked alkyl methacrylate homopolymer or copolymer of two or more alkyl methacrylates 1. with a covalently attached electrically neutral or electrically charged ionophore that is selective for a target cation or anion, or 2. with a covalently attached cationic or anionic ionic site, or 3. with a covalently attached cationic or anionic ionic site and covalently attached electrically neutral or electrically charged ionophore

公开(公告)号：US11567030B2

公开(公告)日：2023-01-31

申请号：US16684285

申请日：2019-11-14

Applicant: Rosemount Inc. ,  Regents of the University of Minnesota

Inventor： Xin Chen ,  Jinbo Hu ,  Philippe Buhlmann

IPC: G01N27/333 ,  B01D61/48 ,  B01D67/00 ,  B01D69/10 ,  B01D71/40 ,  B01D71/82

Abstract: An electrochemical sensor with an ion-selective membrane that comprises a crosslinked alkyl methacrylate homopolymer or copolymer of two or more alkyl methacrylates
1. with a covalently attached electrically neutral or electrically charged ionophore that is selective for a target cation or anion, or
2. with a covalently attached cationic or anionic ionic site, or
3. with a covalently attached cationic or anionic ionic site and covalently attached electrically neutral or electrically charged ionophore.

公开(公告)号：US20240310317A1

公开(公告)日：2024-09-19

申请号：US18243010

申请日：2023-09-06

Applicant: Rosemount Inc. ,  Regents of the University of Minnesota

Inventor： Kwangrok R. Choi ,  Ye Lin ,  Chad McGuire ,  Philippe Buhlmann

IPC: G01N27/333

CPC classification number: G01N27/3335

Abstract: An electrochemical sensor with an ion-selective membrane that is attached through covalent chemical bonds to both an electrically non-conducting polymer substrate (electrode body) and an underlying ion to electron transducer.

公开(公告)号：US11573194B2

公开(公告)日：2023-02-07

申请号：US17095426

申请日：2020-11-11

Applicant: Regents of the University of Minnesota

Inventor： Xin Chen ,  Andreas Stein ,  Philippe Buhlmann

IPC: G01N27/30

Abstract: Reference electrodes that include a solid electron conductor; an interlayer; and a polymeric membrane layer comprising a polymer composition, the polymer composition comprising at least one silicone-containing polymer and at least one ionic liquid, wherein the polymeric membrane layer and the polymer composition are essentially plasticizer free and the silicone-containing polymer and the ionic liquid are miscible as determined using a thermodynamic method that shows a single glass transition temperature (Tg) of a composition including the at least one silicone-containing polymer and the at least one ionic liquid, wherein the interlayer is disposed between the solid electron conductor and the polymeric membrane layer. Also disclosed are electrochemical measurement systems including such reference electrodes.

公开(公告)号：US11307165B2

公开(公告)日：2022-04-19

申请号：US15655457

申请日：2017-07-20

Applicant: Regents of the University of Minnesota

Inventor： Jinbo Hu ,  Philippe Buhlmann ,  Andreas Stein ,  Xue Zhen

IPC: G01N27/333

Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.

公开(公告)号：US11193906B1

公开(公告)日：2021-12-07

申请号：US16818727

申请日：2020-03-13

Applicant: Regents of the University of Minnesota

Inventor： Evan Anderson ,  Philippe Buhlmann ,  Sujay Chopade ,  Marc Hillmyer ,  Tim Lodge

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  G01N27/333 ,  C08J3/24 ,  C08J3/28

Abstract: An electrode and a method of making an electrode includes treating polymers that contain functional groups, which by surface functionalization, such as hydrolysis, ozone treatment or carbon-carbon double-bond oxidation to produce hydroxyl functional groups on the surface. Reacting methacryloyl chloride with the resulting hydroxyl functional groups thereby providing a reactive surface. Photopolymerizing or thermal polymerization of crosslinked acrylate or methacrylate polymers on the reactive surface to produce a membrane covalently bonded to the underlying substrate. In addition such an electrode can also be produced on a polystyrene substrate by reacting methacryloyl chloride with the polystyrene substrate and photopolymerizing or thermally polymerizing to produce crosslinked acrylate or methacrylate polymers on the reactive surface to produce a membrane covalently bonded to the underlying polystyrene substrate.

公开(公告)号：US20210140910A1

公开(公告)日：2021-05-13

申请号：US17095426

申请日：2020-11-11

Applicant: Regents of the University of Minnesota

Inventor： Xin Chen ,  Andreas Stein ,  Philippe Buhlmann

IPC: G01N27/30

Abstract: Reference electrodes that include a solid electron conductor; an interlayer; and a polymeric membrane layer comprising a polymer composition, the polymer composition comprising at least one silicone-containing polymer and at least one ionic liquid, wherein the polymeric membrane layer and the polymer composition are essentially plasticizer free and the silicone-containing polymer and the ionic liquid are miscible as determined using a thermodynamic method that shows a single glass transition temperature (Tg) of a composition including the at least one silicone-containing polymer and the at least one ionic liquid, wherein the interlayer is disposed between the solid electron conductor and the polymeric membrane layer. Also disclosed are electrochemical measurement systems including such reference electrodes.

公开(公告)号：US20180024087A1

公开(公告)日：2018-01-25

申请号：US15655457

申请日：2017-07-20

Applicant: Regents of the University of Minnesota

Inventor： Jinbo Hu ,  Philippe Buhlmann ,  Andreas Stein ,  Xue Zhen

IPC: G01N27/333

CPC classification number: G01N27/333

Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.

公开(公告)号：US09874539B2

公开(公告)日：2018-01-23

申请号：US14716564

申请日：2015-05-19

Applicant: Regents of the University of Minnesota

Inventor： Jinbo Hu ,  Philippe Buhlmann ,  Andreas Stein

IPC: G01N27/414 ,  G01N27/333 ,  G01N27/406 ,  G01N27/403

CPC classification number: G01N27/333 ,  G01N27/4035 ,  G01N27/406 ,  G01N27/414

Abstract: The present description discloses solid-contact (SC) electrodes that use mesoporous carbon such as colloid-imprinted mesoporous (CIM) carbon as the interlayer. The electrodes can be ion-selective electrodes (ISEs) or reference electrodes. The CIM carbon with the interconnected mesopores is used as the intermediate layer between the solid electron conductor, such as gold, and a membrane such as an ionophore-doped ion-selective membrane or a reference membrane. The disclosure includes methods of constructing solid contact electrodes such as SC-ISE or reference electrodes with a CIM carbon interlayer, and methods of using the electrodes to determine the quantity of an analyte in a sample. The description also includes disposable paper-based devices for measuring analytes in a sample.