公开(公告)号：US20240290841A1

公开(公告)日：2024-08-29

申请号：US18581565

申请日：2024-02-20

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven Koester

IPC: H01L29/16 ,  A61B5/08 ,  A61L31/02 ,  C01B32/194 ,  G01N27/04 ,  G01N27/22 ,  G01N33/497 ,  H01L21/02 ,  H01L29/93

CPC classification number: H01L29/1606 ,  A61B5/082 ,  A61L31/024 ,  C01B32/194 ,  G01N27/045 ,  G01N27/228 ,  G01N33/497 ,  H01L29/93 ,  C01B2204/22 ,  G01N2027/222 ,  H01L21/02499 ,  H01L2229/00

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20190331661A1

公开(公告)日：2019-10-31

申请号：US16393177

申请日：2019-04-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/22 ,  G01N27/12

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20220291198A1

公开(公告)日：2022-09-15

申请号：US17707214

申请日：2022-03-29

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/12 ,  G01N27/22

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20220334075A1

公开(公告)日：2022-10-20

申请号：US17719760

申请日：2022-04-13

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Steven Koester ,  Qun Su ,  Philippe Pierre Joseph Buhlmann ,  Xue Zhen ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: G01N27/22 ,  G01N33/497

Abstract: Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.

公开(公告)号：US20220304589A1

公开(公告)日：2022-09-29

申请号：US17689760

申请日：2022-03-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Blair K. Troudt ,  Philippe Pierre Joseph Buhlmann ,  Steven Koester ,  Xue Zhen

IPC: A61B5/08 ,  C01B32/194 ,  B05D1/00 ,  A61B5/05 ,  G01N27/22

Abstract: Embodiments herein relate to chemical sensors based on the non-covalent surface modification of graphene with compounds containing hydrazine or hydroxylamine functional groups for the detection of aldehyde and ketone-bearing analytes. In an embodiment, a medical device is included having a graphene varactor included a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more compounds having one or more hydrazine groups or hydroxylamine groups, substituted hydrazine or hydroxylamine groups, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20210369250A1

公开(公告)日：2021-12-02

申请号：US17328478

申请日：2021-05-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson ,  Xue Zhen

IPC: A61B10/00 ,  C01B32/194 ,  C01G7/00

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor. The graphene varactor includes a graphene layer and at least one non-covalent modification layer disposed on an outer surface of the graphene layer. The non-covalent modification layer can include nanoparticles selected from a group that can include one or more metals, metal oxides, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20210147238A1

公开(公告)日：2021-05-20

申请号：US17096104

申请日：2020-11-12

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Steven J. Koester ,  Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Qun Su ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: C01B32/19 ,  C09D5/00 ,  C09D9/00 ,  C09D127/12 ,  G01N33/00 ,  G01N27/22

Abstract: Embodiments herein relate to methods and systems for applying a transfer material layer to graphene during a graphene fabrication process. In an embodiment, a method of producing a graphene sensor element is included. The method includes forming a graphene layer on a growth substrate and applying a fluoropolymer coating layer over the graphene layer. The method includes removing the growth substrate and transferring the graphene and fluoropolymer coating layers onto a transfer substrate, where the graphene layer is disposed on the transfer substrate and the fluoropolymer layer is disposed on the graphene layer. The method also includes removing the fluoropolymer coating layer. Other embodiments are also included herein.

公开(公告)号：US11923419B2

公开(公告)日：2024-03-05

申请号：US16996537

申请日：2020-08-18

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester

IPC: H01L29/16 ,  A61B5/08 ,  A61L31/02 ,  C01B32/194 ,  G01N27/04 ,  G01N27/22 ,  G01N33/497 ,  H01L29/93 ,  H01L21/02

CPC classification number: H01L29/1606 ,  A61B5/082 ,  A61L31/024 ,  C01B32/194 ,  G01N27/045 ,  G01N27/228 ,  G01N33/497 ,  H01L29/93 ,  C01B2204/22 ,  G01N2027/222 ,  H01L21/02499 ,  H01L2229/00

Abstract: Chemical sensors, devices and systems including the same, and related methods are disclosed. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives of each. Other embodiments are also included.

公开(公告)号：US11867596B2

公开(公告)日：2024-01-09

申请号：US17707214

申请日：2022-03-29

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/12 ,  G01N27/22

CPC classification number: G01N33/497 ,  G01N27/125 ,  G01N27/227 ,  G01N2610/00

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US11307165B2

公开(公告)日：2022-04-19

申请号：US15655457

申请日：2017-07-20

Applicant: Regents of the University of Minnesota

Inventor： Jinbo Hu ,  Philippe Buhlmann ,  Andreas Stein ,  Xue Zhen

IPC: G01N27/333

Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.