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    Formulated insulin-containing composition
    1.
    发明授权
    Formulated insulin-containing composition 失效
    配制含胰岛素的组合物

    公开(公告)号：US5783556A

    公开(公告)日：1998-07-21

    申请号：US696314

    申请日：1996-08-13

    申请人： Ross G. Clark ,  James Q. Oeswein ,  Douglas A. Yeung

    发明人： Ross G. Clark ,  James Q. Oeswein ,  Douglas A. Yeung

    IPC分类号： A61K45/00 ,  A61K9/00 ,  A61K38/27 ,  A61K38/28 ,  A61K38/30 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61P3/10 ,  A61K38/00 ,  A61K38/24

    CPC分类号： A61K9/0019 ,  A61K38/30 ,  A61K47/12 ,  A61K47/02 ,  A61K47/10

    摘要： Formulations containing NPH insulin are useful for treating hyperglycemic disorders, such as diabetes, in a mammal in need of treatment. One such formulation, which is preferably administered parenterally, more preferably by injection, comprises IGF-I and NPH insulin, in amounts of from or about 1 to 10 mg IGF-I and from or about 0.2 to 2 mg NPH insulin in a pharmaceutically acceptable carrier. Another such formulation comprises IGF-I and NPH insulin in an acetic acid salt buffer. Still another formulation comprises IGF-I and NPH insulin in a weight ratio of NPH insulin to IGF-I of from or about 10:1 to 1:50 (w/w), from or about 0.05 to 0.3M of an osmolyte, from or about 0.1 to 10 mg/mL of a stabilizer, and from or about 5 to 100 mM of a buffer at from or about pH 5 to 7. A still further composition comprises NPH insulin in an acetic acid salt buffer.

    摘要翻译： 含有NPH胰岛素的制剂可用于治疗需要治疗的哺乳动物中的高血糖病症，例如糖尿病。 一种这样的制剂，其优选通过胃肠外，更优选通过注射施用，包含IGF-1和NPH胰岛素，其量为约1-10mg IGF-I和约0.2至2mg NPH胰岛素，其药学上可接受的 载体 另一种这样的制剂在乙酸盐缓冲液中包含IGF-1和NPH胰岛素。 另一制剂包含IGF-I和NPH胰岛素，NPH胰岛素与IGF-I的重量比为约10:1至1:50（w / w），或约0.05至0.3M的渗透液，来自 或约0.1至10mg / mL的稳定剂，以及约或约5至100mM的缓冲液，其pH值至约为5至7.还有一种组合物包含在乙酸盐缓冲液中的NPH胰岛素。