公开(公告)号：US08521632B2

公开(公告)日：2013-08-27

申请号：US12508987

申请日：2009-07-24

申请人： Russell E. Planitzer ,  Mark Asdoorian ,  David Brown ,  Ying Chen ,  Leonard Driscoll ,  Jeffrey B. Levering ,  Alex Magary

发明人： Russell E. Planitzer ,  Mark Asdoorian ,  David Brown ,  Ying Chen ,  Leonard Driscoll ,  Jeffrey B. Levering ,  Alex Magary

IPC分类号： G06Q40/00

CPC分类号： G06Q40/06 ,  G06Q30/018 ,  G06Q30/02

摘要： Embodiments of the invention provide techniques for improving clarity of disclosure materials provided to investors, by enabling securities issuers, intermediaries and/or other entities to create and disseminate clear and concise summary-level information on individual securities to investors to enable informed investment decisions. The information may include a summary version of the full statutory prospectus (a “summary prospectus”). A summary prospectus may include a concise, “plain English” synopsis and/or representation of certain information contained in the full statutory prospectus, such as a security's investment objectives and strategies, costs, risks and/or other information.

摘要翻译： 本发明的实施例提供了用于提高向投资者提供的披露材料的清晰度的技术，使得证券发行人，中间商和/或其他实体能够向投资者创建和传播关于个人证券的简明扼要的概要级信息，从而使投资者能够做出明智的投资决策。 该信息可能包括完整的法定招股说明书的简要版本（“简要招股说明书”）。 简要招股说明书可能包括简明扼要的“简明英文”概要和/或完整法定招股说明书中所载某些信息的表示，例如证券的投资目标和策略，成本，风险和/或其他信息。

公开(公告)号：US20100161508A1

公开(公告)日：2010-06-24

申请号：US12508987

申请日：2009-07-24

申请人： Russell E. Planitzer ,  Mark Asdoorian ,  David Brown ,  Ying Chen ,  Leonard Driscoll ,  Jeffrey B. Levering ,  Alex Magary

发明人： Russell E. Planitzer ,  Mark Asdoorian ,  David Brown ,  Ying Chen ,  Leonard Driscoll ,  Jeffrey B. Levering ,  Alex Magary

IPC分类号： G06Q40/00

CPC分类号： G06Q40/06 ,  G06Q30/018 ,  G06Q30/02

摘要： Embodiments of the invention provide techniques for improving clarity of disclosure materials provided to investors, by enabling securities issuers, intermediaries and/or other entities to create and disseminate clear and concise summary-level information on individual securities to investors to enable informed investment decisions. The information may include a summary version of the full statutory prospectus (a “summary prospectus”). A summary prospectus may include a concise, “plain English” synopsis and/or representation of certain information contained in the full statutory prospectus, such as a security's investment objectives and strategies, costs, risks and/or other information.

摘要翻译： 本发明的实施例提供了用于提高向投资者提供的披露材料的清晰度的技术，使得证券发行人，中间商和/或其他实体能够向投资者创建和传播关于个人证券的简明扼要的概要级信息，从而使投资者能够做出明智的投资决策。 该信息可能包括完整的法定招股说明书的简要版本（“简要招股说明书”）。 简要招股说明书可能包括简明扼要的“简明英文”概要和/或完整法定招股说明书中所载某些信息的表示，例如证券的投资目标和策略，成本，风险和/或其他信息。

公开(公告)号：US20050131760A1

公开(公告)日：2005-06-16

申请号：US10736770

申请日：2003-12-16

申请人： Miriam Manning ,  David Brown ,  Leo Maldonado ,  Bruce McCarthy ,  Mark Asdoorian ,  Chet Graham

发明人： Miriam Manning ,  David Brown ,  Leo Maldonado ,  Bruce McCarthy ,  Mark Asdoorian ,  Chet Graham

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q30/0281

摘要： Advanced prospecting features for generating targeted business-to-business sales leads and mailing lists allow users to save time and money by having the ability to preview all leads prior to purchasing, by suppressing previously licensed lists against new lists, by analyzing a list prior to purchasing it, searching on both primary and secondary standard industry classification (SIC) codes, and by having the ability to dedupe duplicate records in a list.

摘要翻译： 用于生成有针对性的企业对企业销售线索和邮寄列表的高级探索功能允许用户通过在购买之前预览所有潜在客户来节省时间和金钱，通过先前许可的列表对新列表进行排序，通过在 购买它，搜索主要和次要标准行业分类（SIC）代码，并具有在列表中重复数据删除重复记录的能力。

公开(公告)号：US20070249615A1

公开(公告)日：2007-10-25

申请号：US11737966

申请日：2007-04-20

申请人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

发明人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

IPC分类号： A61K31/498 ,  C07D487/02

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：US20240026317A1

公开(公告)日：2024-01-25

申请号：US18249023

申请日：2021-10-13

申请人： Dong SHEN ,  David BROWN ,  Renxiang CHEN ,  RNAimmune, Inc

发明人： Dong Shen ,  David Brown ,  Renxiang Chen

IPC分类号： C12N9/14 ,  C12P19/30 ,  A61K39/00 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61K47/54

CPC分类号： C12N9/14 ,  C12Y306/05002 ,  C12P19/30 ,  A61K39/001164 ,  A61K9/1273 ,  A61K47/6911 ,  A61P35/00 ,  A61K47/54 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/55555

摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

公开(公告)号：US11345606B2

公开(公告)日：2022-05-31

申请号：US15435318

申请日：2017-02-17

申请人： David Brown

发明人： David Brown

IPC分类号： G02B6/02 ,  C01G23/053 ,  C01G49/06 ,  C01B33/18

摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.

公开(公告)号：USD819777S1

公开(公告)日：2018-06-05

申请号：US29581051

申请日：2016-10-14

申请人： David Brown

设计人： David Brown

公开(公告)号：US20170128079A1

公开(公告)日：2017-05-11

申请号：US15343765

申请日：2016-11-04

申请人： David Brown

发明人： David Brown

IPC分类号： A61B17/15

CPC分类号： A61B17/155

摘要： An integrated instrument for arthroplasty planning comprises a cutting block having an adjustable distance between an anterior cut guide and a posterior cut guide, and a sizer mounted to the cutting block, the sizer comprising medial and lateral posterior feet having an adjustable distance from one of the cut guides and an adjustable angular position relative to the one of the cut guides.

公开(公告)号：US09612287B2

公开(公告)日：2017-04-04

申请号：US13461862

申请日：2012-05-02

申请人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

发明人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

IPC分类号： H02J7/00 ,  G01R31/36 ,  H02J9/04

CPC分类号： G01R31/3631 ,  G01R31/3658 ,  G01R31/3662 ,  H02J7/0021 ,  H02J9/04

摘要： Non-sequential monitoring of battery cells in battery monitoring systems, and related components, systems, and methods are disclosed. In one embodiment, a battery monitoring system control unit is provided. The battery monitoring system control unit is configured to control battery monitoring devices. Each battery monitoring device is configured to be coupled to a subset of battery cells electrically connected in series in a sequential order to form a battery. The battery monitoring system control unit is further configured to instruct the battery monitoring devices to test an ohmic value of each battery cell of the battery cells of the battery in a non-sequential order. In this manner, heat generated in the battery monitoring devices from the testing may be more effectively dissipated, which can also allow for the battery monitoring devices to be employed in higher operating temperature environments.

公开(公告)号：US20160130026A1

公开(公告)日：2016-05-12

申请号：US14534692

申请日：2014-11-06

申请人： David Brown ,  Sheletia Brown

发明人： David Brown ,  Sheletia Brown

IPC分类号： B65D1/02 ,  B65D41/04 ,  B65D47/06 ,  B65D1/40

CPC分类号： B65D1/0292 ,  B65D1/0284 ,  B65D1/40 ,  B65D2501/0036

摘要： A collapsible beverage containment assembly includes a bottle. The bottle has an outer wall extending between a top end and a bottom end of the bottle to contain a carbonated fluid. The outer wall is structured such that the bottle is collapsible. A sleeve is coupled to the bottom end. The sleeve is positioned within an interior of the bottle. A lid is movably coupled to the top end so the lid may be rotated. A screw is coupled to the lid such that the screw extends downwardly into the bottle. The screw engages the sleeve. Thus, the outer wall is collapsed when the lid is rotated to reduce a volume of the bottle, preserving the carbonation in the carbonated beverage.

摘要翻译： 可折叠的饮料容纳组件包括瓶子。 瓶子具有在瓶的顶端和底端之间延伸以容纳碳酸液体的外壁。 外壁的结构使得瓶子可折叠。 套筒连接到底端。 套筒位于瓶子的内部。 盖子可移动地联接到顶端，因此盖子可以旋转。 螺钉联接到盖上，使得螺钉向下延伸到瓶中。 螺钉接合套筒。 因此，当盖旋转以减小瓶的体积时，外壁被折叠，从而保持碳酸饮料中的碳酸化。