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1.发明授权Cyanide-free lytic reagent composition and method of use for hemoglobin and white blood cell measurement 有权无氰溶剂试剂组合物及血红蛋白和白细胞测定方法公开(公告)号：US07235404B2
公开(公告)日：2007-06-26
申请号：US11125395
申请日：2005-05-04
CPC分类号： G01N33/721 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25
摘要： A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition includes a quaternary ammonium surfactant to lyse red blood cells and release hemoglobin and a ligand to form a stable chromogen with the hemoglobin. The lytic reagent composition has a pH in a range of 3 to 10. The lytic reagent composition can also include a second quaternary ammonium surfactant. The ligand can be malic acid, malonic acid, ethylene diamine, N,N-diethylethylene diamine, N,N′-diethylethylene diamine, diethylene triamine, tetraethylene pentamine, 1,6-hexanediamine, 1,3-pentanediamine, 2-methylpentamethylenediamine, 1,2-diaminocyclohexane, 4-aminoacetophenone, bis-hexamethylenetriamine, pyridazine, or 3,6-dihyroxypyridazine.
摘要翻译： 公开了一种无氰溶解试剂组合物和用于测量血液样品中总血红蛋白浓度和白细胞的方法。 溶解试剂组合物包括季铵表面活性剂以溶解红细胞并释放血红蛋白和配体以与血红蛋白形成稳定的色原体。 溶解试剂组合物的pH值在3至10的范围内。裂解试剂组合物还可包括第二季铵表面活性剂。 配体可以是苹果酸，丙二酸，乙二胺，N，N-二乙基乙二胺，N，N'-二乙基乙二胺，二亚乙基三胺，四亚乙基五胺，1,6-己二胺，1,3-戊二胺，2-甲基戊二胺， 1,2-二氨基环己烷，4-氨基苯乙酮，双六亚甲基三胺，哒嗪或3,6-二羟基哒嗪。
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2.发明申请REACTIVITY OF HYDROXYMETHYLGLUTARYL COENZYME A (HMG-COA) REDUCTASE INHIBITORS CONTAINING CONJUGATED DIENES WITH PHENOLIC ANTIOXIDANTS IN THE SOLID-STATE 审中-公开含有固体二氧化锰的羟基甲基丙烯酸缩水甘油A（HMG-COA）还原酶抑制剂与酚醛类抗生素的反应性公开(公告)号：US20120232290A1
公开(公告)日：2012-09-13
申请号：US13437330
申请日：2012-04-02
申请人： Russell F. Lang
发明人： Russell F. Lang
IPC分类号： C07D309/30
CPC分类号： C07D311/30 , C07D309/30
摘要： The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.
摘要翻译： 本发明的目的是探测没有自由基引发剂的洛伐他汀，辛伐他汀，普伐他汀和美伐他汀在固态中的反应性，以确定提供他汀类药物最佳稳定性的抗氧化剂。 评估酚类抗氧化剂。
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3.发明申请Reactivity of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Containing Conjugated Dienes with Phenolic Antioxidants in the Solid-State 审中-公开羟基甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂在固态中含有酚类抗氧化剂的共轭二烯的反应性公开(公告)号：US20080312458A1
公开(公告)日：2008-12-18
申请号：US12139222
申请日：2008-06-13
申请人： Russell F. Lang
发明人： Russell F. Lang
IPC分类号： C07D311/72 , C07C43/23 , C07C69/88
CPC分类号： C07D311/30
摘要： The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.
摘要翻译： 本发明的目的是探测没有自由基引发剂的洛伐他汀，辛伐他汀，普伐他汀和美伐他汀在固态中的反应性，以确定提供他汀类药物最佳稳定性的抗氧化剂。 评估酚类抗氧化剂。
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公开(公告)号：US06706526B2
公开(公告)日：2004-03-16
申请号：US10056617
申请日：2002-01-24
IPC分类号： G01N3100
CPC分类号： G01N33/5094 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/202499 , Y10T436/2525
摘要： A low formaldehyde containing aqueous blood diluent contains an effective amount of ethylenediamine tetraacetic acid, ethylenediamine tetraacetic acid derivative, or combinations thereof; an effective amount of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one; and an effective amount of 5-bromo-5-nitro-1,3-dioxane. Advantageously, less than about 1 parts per million of formaldehyde is produced in this multipurpose diluent. A method of analyzing a blood sample containing blood cells is conducted by forming a diluted blood sample by mixing a blood sample containing blood cells with this diluent and analyzing the diluted blood sample to determine a physical parameter of the blood cells.
摘要翻译： 低含甲醛的含水稀释剂含有有效量的乙二胺四乙酸，乙二胺四乙酸衍生物或其组合; 有效量的5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮; 和有效量的5-溴-5-硝基-1,3-二恶烷。 有利的是，在该多用途稀释剂中产生少于约1ppm的甲醛。 通过将含有血细胞的血液样品与该稀释剂混合并分析稀释的血液样品来确定血细胞的物理参数，通过形成稀释的血液样品来进行含有血细胞的血液样品的分析方法。
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