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1.发明授权Co-administration of interleukin-3 mutants with colony stimulating factors 失效白细胞介素-3突变体与集落刺激因子的共同给药
公开(公告)号：US5997857A
公开(公告)日：1999-12-07
申请号：US470509
申请日：1995-06-06
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , A61P7/06 , C07K14/53 , C07K14/54 , C12N15/24 , C12P21/02
CPC分类号： C07K14/5403 , A61K38/1816 , A61K38/193 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
摘要翻译： 本发明涉及与其他集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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2.发明授权Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors 失效用于共同给予白细胞介素-3突变体和其他细胞因子和造血因子的组合物
公开(公告)号：US5772992A
公开(公告)日：1998-06-30
申请号：US191973
申请日：1994-02-04
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , A61P7/06 , C07K14/53 , C07K14/54 , C12N15/24 , C12P21/02 , A61K38/19
CPC分类号： C07K14/5403 , A61K38/1816 , A61K38/193 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The invention provides compositions comprising a human interleukin-3 (hIL-3) variant or mutant protein (mutein) and another colony stimulating factor, cytokine, lymphokine, interleukin, or hematopoietic growth factor. The compositions are useful for the therapeutic co-administration of the proteins, as for example in hematopoietic reconstitution. factors or IL-3 variants.
摘要翻译： 本发明提供包含人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）和另一种集落刺激因子，细胞因子，淋巴因子，白细胞介素或造血生长因子的组合物。 该组合物可用于治疗性共同给予蛋白质，例如在造血重建中。 因子或IL-3变体。
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3.发明授权
公开(公告)号：US6057133A
公开(公告)日：2000-05-02
申请号：US192325
申请日：1994-02-04
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A47B47/02 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , C07H21/04 , C07K20060101 , C07K14/52 , C07K14/53 , C07K14/54 , C07K19/00 , C12N1/21 , C12N15/24 , C12N15/26 , C12N15/27 , C12N15/62 , C12N15/63 , C12P21/02 , C12R1/19
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin, hematopoietic growth factor or IL-3 variant. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
摘要翻译： 本发明涉及由人白细胞介素-3（hIL-3）变体或与第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素，造血生长因子或IL-3功能性连接的突变蛋白（突变蛋白） 变体。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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公开(公告)号：US6132991A
公开(公告)日：2000-10-17
申请号：US469124
申请日：1995-06-06
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61P7/06 , C07K14/53 , C07K14/535 , C07K14/54 , C07K19/00 , C12N15/24 , C12P21/02 , A61K38/20
CPC分类号： C07K14/535 , C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
摘要翻译： 本发明涉及由功能性地连接到第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素或IL-3变体的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）组成的融合分子。 这些hIL-3变体含有氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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5.发明授权Ex vivo expansion of hematopoietic cells using interleukin-3 (IL-3) variant fusion proteins 失效使用白细胞介素-3（IL-3）变体融合蛋白体外扩增造血细胞
公开(公告)号：US6074639A
公开(公告)日：2000-06-13
申请号：US559267
申请日：1995-11-15
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61P7/06 , C07K14/53 , C07K14/535 , C07K14/54 , C07K19/00 , C12N15/24 , C12P21/02 , A61K38/20
CPC分类号： C07K14/535 , C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
摘要翻译： 本发明涉及由功能性地连接到第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素或IL-3变体的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）组成的融合分子。 这些hIL-3变体包含氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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6.发明授权Ex-vivo expansion of stem cells using combinations of interleukin-3 (IL-3) variants and other cytokines 失效使用白细胞介素-3（IL-3）变体和其他细胞因子的组合进行干细胞的离体扩增
公开(公告)号：US5997860A
公开(公告)日：1999-12-07
申请号：US559009
申请日：1995-11-15
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , A61P7/06 , C07K14/53 , C07K14/54 , C12N15/24 , C12P21/02 , A61K35/14
CPC分类号： C07K14/5403 , A61K38/1816 , A61K38/193 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
摘要翻译： 本发明涉及与其它集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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7.发明授权Therapeutic methods using fusion proteins between interleukin-3 (IL-3) variants and other hematopoietic factors 失效使用白细胞介素-3（IL-3）变体和其他造血因子之间的融合蛋白的治疗方法
公开(公告)号：US5858347A
公开(公告)日：1999-01-12
申请号：US470775
申请日：1995-06-06
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61P7/06 , C07K14/53 , C07K14/535 , C07K14/54 , C07K19/00 , C12N15/24 , C12P21/02 , A61K38/20 , C12N15/74
CPC分类号： C07K14/535 , C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
摘要翻译： 本发明涉及由功能性地连接到第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素或IL-3变体的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）组成的融合分子。 这些hIL-3变体含有氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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8.发明授权Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them 失效白细胞介素-3（IL-3）变体融合蛋白，其重组生产和包含它们的治疗组合物
公开(公告)号：US5738849A
公开(公告)日：1998-04-14
申请号：US192299
申请日：1994-02-04
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61P7/06 , C07K14/53 , C07K14/535 , C07K14/54 , C07K19/00 , C12N15/24 , C12P21/02 , A61K38/19 , A61K38/20 , C12N15/62
CPC分类号： C07K14/535 , C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
摘要翻译： 本发明涉及由功能性地连接到第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素或IL-3变体的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）组成的融合分子。 这些hIL-3变体含有氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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9.发明授权Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides 失效使用白细胞介素-3（IL-3）多重突变多肽的造血细胞离体扩增的方法公开(公告)号：US06440407B1
公开(公告)日：2002-08-27
申请号：US08764114
申请日：1996-12-09
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC分类号： C12N508
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
摘要翻译： 本发明涉及通过在包含多个氨基酸取代的人白细胞介素-3（hIL-3）的变体的生长培养基中培养造血细胞而造血细胞离体扩增的方法，其可以具有天然hIL的部分 -3分子删除。 本发明还涉及用于基因治疗的造血细胞的离体扩增。 此外，本发明涉及扩大的造血细胞用于治疗造血障碍的患者的用途。
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10.发明授权Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins 失效使用多变量IL-3造血嵌合体蛋白质造血细胞离体扩增的方法公开(公告)号：US06436387B1
公开(公告)日：2002-08-20
申请号：US08762227
申请日：1996-12-09
申请人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
发明人： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC分类号： A61K4500
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
摘要翻译： 本发明涉及通过在包含嵌合体蛋白质的生长培养基中培养造血细胞的造血细胞的离体扩增方法，所述嵌合体蛋白质包含含有多个氨基酸取代的人白细胞介素-3（hIL-3）的变体， 天然hIL-3分子缺失的部分和造血生长因子。 本发明还涉及用于基因治疗的造血细胞的离体扩增。 此外，本发明涉及扩大的造血细胞用于治疗造血障碍的患者的用途。
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