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1.发明授权Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides 失效使用白细胞介素-3（IL-3）多重突变多肽的造血细胞离体扩增的方法公开(公告)号：US06440407B1
公开(公告)日：2002-08-27
申请号：US08764114
申请日：1996-12-09
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC: C12N508
CPC classification number: C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
Abstract translation: 本发明涉及通过在包含多个氨基酸取代的人白细胞介素-3（hIL-3）的变体的生长培养基中培养造血细胞而造血细胞离体扩增的方法，其可以具有天然hIL的部分 -3分子删除。 本发明还涉及用于基因治疗的造血细胞的离体扩增。 此外，本发明涉及扩大的造血细胞用于治疗造血障碍的患者的用途。
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2.发明授权Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins 失效使用多变量IL-3造血嵌合体蛋白质造血细胞离体扩增的方法公开(公告)号：US06436387B1
公开(公告)日：2002-08-20
申请号：US08762227
申请日：1996-12-09
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC: A61K4500
CPC classification number: C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
Abstract translation: 本发明涉及通过在包含嵌合体蛋白质的生长培养基中培养造血细胞的造血细胞的离体扩增方法，所述嵌合体蛋白质包含含有多个氨基酸取代的人白细胞介素-3（hIL-3）的变体， 天然hIL-3分子缺失的部分和造血生长因子。 本发明还涉及用于基因治疗的造血细胞的离体扩增。 此外，本发明涉及扩大的造血细胞用于治疗造血障碍的患者的用途。
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3.发明授权Co-administration of interleukin-3 mutants with colony stimulating factors 失效白细胞介素-3突变体与集落刺激因子的共同给药
公开(公告)号：US5997857A
公开(公告)日：1999-12-07
申请号：US470509
申请日：1995-06-06
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC: C12N15/09 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , A61P7/06 , C07K14/53 , C07K14/54 , C12N15/24 , C12P21/02
CPC classification number: C07K14/5403 , A61K38/1816 , A61K38/193 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
Abstract translation: 本发明涉及与其他集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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4.发明授权Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors 失效用于共同给予白细胞介素-3突变体和其他细胞因子和造血因子的组合物
公开(公告)号：US5772992A
公开(公告)日：1998-06-30
申请号：US191973
申请日：1994-02-04
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC: C12N15/09 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , A61P7/06 , C07K14/53 , C07K14/54 , C12N15/24 , C12P21/02 , A61K38/19
CPC classification number: C07K14/5403 , A61K38/1816 , A61K38/193 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The invention provides compositions comprising a human interleukin-3 (hIL-3) variant or mutant protein (mutein) and another colony stimulating factor, cytokine, lymphokine, interleukin, or hematopoietic growth factor. The compositions are useful for the therapeutic co-administration of the proteins, as for example in hematopoietic reconstitution. factors or IL-3 variants.
Abstract translation: 本发明提供包含人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）和另一种集落刺激因子，细胞因子，淋巴因子，白细胞介素或造血生长因子的组合物。 该组合物可用于治疗性共同给予蛋白质，例如在造血重建中。 因子或IL-3变体。
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5.发明授权Fusion proteins comprising multiply mutated interleukin-3 (IL-3) polypeptides and second growth factors 失效包含多重突变白细胞介素-3（IL-3）多肽和第二生长因子的融合蛋白
公开(公告)号：US6030812A
公开(公告)日：2000-02-29
申请号：US468609
申请日：1995-06-06
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan M. Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan M. Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC: C12N15/09 , A47B47/02 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , C07H21/04 , C07K20060101 , C07K14/52 , C07K14/53 , C07K14/54 , C07K19/00 , C12N1/21 , C12N15/24 , C12N15/26 , C12N15/27 , C12N15/62 , C12N15/63 , C12P21/02 , C12R1/19
CPC classification number: C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
Abstract translation: 本发明涉及与其他集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体融合的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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Patent Agency Ranking6.发明授权Treatment of hematopoietic disorders with fusion proteins comprising multiply mutated interleukin-3 (IL-3) polypeptides and second growth factors 失效用包含多重突变白细胞介素-3（IL-3）多肽和第二生长因子的融合蛋白治疗造血障碍
公开(公告)号：US6022535A
公开(公告)日：2000-02-08
申请号：US469318
申请日：1995-06-06
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helen Caparon , Alan M. Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helen Caparon , Alan M. Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC: C12N15/09 , A47B47/02 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , C07H21/04 , C07K20060101 , C07K14/52 , C07K14/53 , C07K14/54 , C07K19/00 , C12N1/21 , C12N15/24 , C12N15/26 , C12N15/27 , C12N15/62 , C12N15/63 , C12P21/02 , C12R1/19
CPC classification number: C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
Abstract translation: 本发明涉及与其他集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体融合的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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7.发明授权Enhanced protein production in bacteria by employing a novel ribosome binding site 失效通过使用新的核糖体结合位点增强细菌中的蛋白质产生
公开(公告)号：US5232840A
公开(公告)日：1993-08-03
申请号：US639458
申请日：1991-01-10
Applicant: Peter O. Olins
Inventor： Peter O. Olins
CPC classification number: C12N9/1085 , C07K14/61 , C07K14/65 , C12N15/70
Abstract: The present invention provides novel ribosome binding sites useful in enhancing protein production in bacteria. Methods, genes, vectors, bacteria and useful intermediates employing the novel ribosome binding sites of the present invention are also provided. A novel site of interaction different from a Shine-Dalgarno sequence between the 16S ribosomal RNA and messenger RNA is also provided.
Abstract translation: 本发明提供了可用于增强细菌中蛋白质生产的新型核糖体结合位点。 还提供了使用本发明的新型核糖体结合位点的方法，基因，载体，细菌和有用的中间体。 还提供了与16S核糖体RNA和信使RNA之间的Shine-Dalgarno序列不同的新的相互作用位点。
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8.发明授权Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production 失效将白细胞介素-3突变体多肽与CSFS共同给予多谱系造血细胞生产公开(公告)号：US06361976B1
公开(公告)日：2002-03-26
申请号：US08446871
申请日：1995-06-06
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
IPC: C12N2100
CPC classification number: C07K14/5403 , A61K38/00 , A61K38/18 , A61K38/1816 , A61K38/193 , A61K38/20 , A61K38/27 , C07K2319/00 , C07K2319/02 , A61K2300/00
Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
Abstract translation: 本发明涉及与其它集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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9.发明授权Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production 失效共同给予白细胞介素-3突变体多肽与CSF用于多系造血细胞生产
公开(公告)号：US6060047A
公开(公告)日：2000-05-09
申请号：US471045
申请日：1995-06-06
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John P. McKearn , Peter O. Olins , Kumnan Paik , John W. Thomas
CPC classification number: A61K45/00 , A61K38/1816 , A61K38/193 , C07K14/5403 , A61K38/00
Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
Abstract translation: 本发明涉及与其他集落刺激因子（CSF），细胞因子，淋巴因子，白介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。
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10.发明授权
公开(公告)号：US6057133A
公开(公告)日：2000-05-02
申请号：US192325
申请日：1994-02-04
Applicant: S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
Inventor： S. Christopher Bauer , Mark Allen Abrams , Sarah Ruth Braford-Goldberg , Maire Helena Caparon , Alan Michael Easton , Barbara Kure Klein , John Patrick McKearn , Peter O. Olins , Kumnan Paik , John Warren Thomas
IPC: C12N15/09 , A47B47/02 , A61K38/00 , A61K38/20 , A61K38/22 , A61K38/27 , A61P7/00 , C07H21/04 , C07K20060101 , C07K14/52 , C07K14/53 , C07K14/54 , C07K19/00 , C12N1/21 , C12N15/24 , C12N15/26 , C12N15/27 , C12N15/62 , C12N15/63 , C12P21/02 , C12R1/19
CPC classification number: C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02
Abstract: The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin, hematopoietic growth factor or IL-3 variant. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
Abstract translation: 本发明涉及由人白细胞介素-3（hIL-3）变体或与第二集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素，造血生长因子或IL-3功能性连接的突变蛋白（突变蛋白） 变体。 本发明还涉及含有该融合分子的药物组合物及其使用方法。
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