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公开(公告)号：US08252554B2
公开(公告)日：2012-08-28
申请号：US12505374
申请日：2009-07-17
申请人： S. Christopher Davis , Lisa Marie Newman , Vesna Gavrilovic , Gjalt W. Huisman , Richard John Fox , Emily C. Mundorff
发明人： S. Christopher Davis , Lisa Marie Newman , Vesna Gavrilovic , Gjalt W. Huisman , Richard John Fox , Emily C. Mundorff
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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公开(公告)号：US07588928B2
公开(公告)日：2009-09-15
申请号：US11266747
申请日：2005-11-02
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa Marie Newman
IPC分类号： C12N9/88
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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公开(公告)号：US07824898B2
公开(公告)日：2010-11-02
申请号：US10917179
申请日：2004-08-11
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US07541171B2
公开(公告)日：2009-06-02
申请号：US11067323
申请日：2005-02-23
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
IPC分类号： C12N9/88
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US20120208259A1
公开(公告)日：2012-08-16
申请号：US13349514
申请日：2012-01-12
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US20100167345A1
公开(公告)日：2010-07-01
申请号：US12573824
申请日：2009-10-05
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US08101395B2
公开(公告)日：2012-01-24
申请号：US12573824
申请日：2009-10-05
申请人： S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US07833767B2
公开(公告)日：2010-11-16
申请号：US12576195
申请日：2009-10-08
CPC分类号： C12N9/0006
摘要： The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
摘要翻译： 本发明涉及具有增强的酮还原酶活性和/或用于酮的立体特异性还原的热稳定性的变体多肽。 此外，本发明涉及编码酮还原酶多肽的多核苷酸，包括提供宿主细胞中增强表达的多核苷酸的密码子优化形式。 在另一方面，本发明涉及用本发明的多核苷酸转化的核苷酸构建体，载体和宿主细胞。
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公开(公告)号：US07629157B2
公开(公告)日：2009-12-08
申请号：US10916311
申请日：2004-08-11
CPC分类号： C12N9/0006
摘要： The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
摘要翻译： 本发明涉及具有增强的酮还原酶活性和/或用于酮的立体特异性还原的热稳定性的变体多肽。 此外，本发明涉及编码酮还原酶多肽的多核苷酸，包括提供宿主细胞中增强表达的多核苷酸的密码子优化形式。 在另一方面，本发明涉及用本发明的多核苷酸转化的核苷酸构建体，载体和宿主细胞。
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10.发明申请公开(公告)号：US20100028972A1
公开(公告)日：2010-02-04
申请号：US12576195
申请日：2009-10-08
CPC分类号： C12N9/0006
摘要： The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
摘要翻译： 本发明涉及具有增强的酮还原酶活性和/或用于酮的立体特异性还原的热稳定性的变体多肽。 此外，本发明涉及编码酮还原酶多肽的多核苷酸，包括提供宿主细胞中增强表达的多核苷酸的密码子优化形式。 在另一方面，本发明涉及用本发明的多核苷酸转化的核苷酸构建体，载体和宿主细胞。
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