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1.发明申请METHODS OF MAKING HIV ATTACHMENT INHIBITOR PRODRUG COMPOUND AND INTERMEDIATES 有权制备HIV附着抑制剂制剂化合物和中间体的方法公开(公告)号：US20130030178A1
公开(公告)日：2013-01-31
申请号：US13359708
申请日：2012-01-27
Applicant: Jonathan Clive Tripp , Dayne Dustan Fanfair , Mitchell J. Schultz , Saravanababu Murugesan , Richard J. Fox , Chung-Pin H. Chen , Sabrina E. Ivy , Joseph Francis Payack , Wendel W. Doubleday
Inventor： Jonathan Clive Tripp , Dayne Dustan Fanfair , Mitchell J. Schultz , Saravanababu Murugesan , Richard J. Fox , Chung-Pin H. Chen , Sabrina E. Ivy , Joseph Francis Payack , Wendel W. Doubleday
IPC: C07F9/6561 , C07D471/04
CPC classification number: C07D471/04 , C07F9/6561
Abstract: A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.
Abstract translation: 制备式I化合物的方法使用烷基化，酰胺化，氯化和磷酸盐安装方法进行说明。
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公开(公告)号：US20090298125A1
公开(公告)日：2009-12-03
申请号：US12505374
申请日：2009-07-17
Applicant: S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa M. Newman
Inventor： S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa M. Newman
Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Abstract translation: 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US06869549B2
公开(公告)日：2005-03-22
申请号：US10228719
申请日：2002-08-27
Applicant: Scott Frederick Ansell , Michael W. Litwin , Gregory L. Berckmiller , Timothy P. Freeman , Richard J. Fox , Robert B. Phillips , Thomas R. Daniels , Richard F. Barbas , Gerald R. Krebsbach
Inventor： Scott Frederick Ansell , Michael W. Litwin , Gregory L. Berckmiller , Timothy P. Freeman , Richard J. Fox , Robert B. Phillips , Thomas R. Daniels , Richard F. Barbas , Gerald R. Krebsbach
CPC classification number: B29D11/0048 , B29C33/3842 , B29C33/40 , B29C33/44 , B29C45/2673 , B29C2045/2679 , B29D11/00125 , B29L2011/0041 , B29L2031/757 , Y10S425/808
Abstract: This invention provides a method and a mold for improving the release of a molded ophthalmic device from a mold. The method comprises the steps of: providing a first mold half and second mold half each having opposing top surfaces at least one of which has been hollowed out to define a cavity for forming said ophthalmic device and at least said first mold half further defining a boundary for a release element, said boundary is part of said cavity, said release element comprising a ramped surface, said cavity having a corresponding ramped surface, and said release element having its widest part near the top surface of said at least said first mold half that defines said release element therein. The mold of this invention has a hollowed-out portion as part of the cavity to provide a release element to the molded ophthalmic device.
Abstract translation: 本发明提供一种用于改进模制眼科装置从模具中释放的方法和模具。 该方法包括以下步骤：提供第一半模和第二半模，其具有相对的顶表面，其中至少一个已被挖空以形成用于形成所述眼科装置的空腔，并且至少所述第一半模进一步限定边界 所述释放元件包括倾斜表面，所述空腔具有相应的倾斜表面，并且所述释放元件具有靠近所述至少所述第一半模的上表面的最宽部分， 在其中限定所述释放元件。 本发明的模具具有作为空腔的一部分的中空部分，以向模制的眼科装置提供释放元件。
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公开(公告)号：US06419219B2
公开(公告)日：2002-07-16
申请号：US09835421
申请日：2001-04-16
Applicant: Karl P. Schaefer , Ingermar S. d'Agrella , Richard J. Fox
Inventor： Karl P. Schaefer , Ingermar S. d'Agrella , Richard J. Fox
IPC: B65H3900
CPC classification number: B65H29/40 , B65H2404/6591
Abstract: A delivery apparatus for sorting a single stream of signatures into two or more streams, the apparatus includes two counter-rotating bucket assemblies. Each bucket assembly includes a plurality of buckets spaced from one another along a common axis. The respective common axis of each bucket assembly is disposed parallel to the common axis of the other. Each of the buckets of one of the bucket assemblies is disposed adjacent to and in a respective common plane with a respective one of the buckets of the other of the bucket assemblies. Further, each of the buckets includes a plurality of blades, the tips of the blades of each bucket defining a circumference. A respective circumference of one bucket overlaps the circumference of the other bucket disposed in the common plane. Two neighboring blades have respective surfaces defining a slot therebetween. Each slot includes a first generally wedge-shaped portion defined by a first planar surface and a second planar surface disposed at a first angle from the first planar surface, and a second generally wedge-shaped portion defined by a third planar surface and a fourth planar surface disposed at a second angle from the third planar surface. The second angle is smaller than the first angle.
Abstract translation: 一种用于将单个签名流分类成两个或更多个流的递送装置，该装置包括两个反向旋转桶组件。 每个铲斗组件包括沿公共轴彼此间隔开的多个铲斗。 每个铲斗组件的相应公共轴线平行于另一个的公共轴线布置。 其中一个铲斗组件的每个铲斗都布置成与相应的公共平面相邻并且与另一个铲斗组件中的相应的一个铲斗相配合。 此外，每个铲斗包括多个叶片，每个铲斗的叶片的尖端限定圆周。 一个斗的相应圆周与设置在公共平面中的另一个铲斗的圆周重叠。 两个相邻的刀片具有限定它们之间的槽的相应表面。 每个狭槽包括由第一平坦表面和与第一平坦表面成第一角度设置的第二平坦表面限定的第一大致楔形部分和由第三平面和第四平面限定的第二大致楔形部分 表面以与第三平面相反的第二角度设置。 第二角度小于第一角度。
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5.发明授权System and method for the advanced prediction of weather impact on managerial planning applications 失效对管理规划应用的天气影响的高级预测的系统和方法
公开(公告)号：US5521813A
公开(公告)日：1996-05-28
申请号：US2847
申请日：1993-01-15
Applicant: Frederic D. Fox , Richard J. Fox , Michael A. Rhoads , Douglas R. Pearson , William R. Young
Inventor： Frederic D. Fox , Richard J. Fox , Michael A. Rhoads , Douglas R. Pearson , William R. Young
CPC classification number: G06Q10/06 , G06Q30/0201 , Y10S706/923 , Y10S706/925
Abstract: A computer-based system and method which incorporates long-range weather forecasts in a predictive model which quantifies historical weather impact relationships between datasets, and uses the long-range weather forecasts to predict future weather impact on managerial plans. The predictive model can use multiple regression or a neural network. In a retail application, the computer-based system and method has a weather impact predictive model based on correlations of historical weather and point-of-sale store transactions data. The weather impact model is coupled with long-range weather forecasts to adjust managerial plans for buying, distribution, financial budgeting, promotional and advertising applications. A graphical user interface provides easy assimilation of analysis for specific managerial planning applications.
Abstract translation: 一种基于计算机的系统和方法，其在预测模型中包含长距离天气预报，量化数据集之间的历史天气影响关系，并使用长距离天气预报来预测未来对管理计划的天气影响。 预测模型可以使用多元回归或神经网络。 在零售应用中，基于计算机的系统和方法具有基于历史天气和销售点商店交易数据的相关性的天气影响预测模型。 天气影响模型加上长距离天气预报，以调整购买，分销，财务预算，促销和广告应用的管理计划。 图形用户界面为特定的管理规划应用程序提供了轻松的同化分析。
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Patent Agency Ranking
公开(公告)号：US5319670A
公开(公告)日：1994-06-07
申请号：US918095
申请日：1992-07-24
Applicant: Richard J. Fox
Inventor： Richard J. Fox
IPC: H05B6/32
CPC classification number: H05B6/32
Abstract: A system for damping oscillatory and spinning motions induced in an electromagnetically levitated material. Two opposed field magnets are located orthogonally to the existing levitation coils for providing a DC quadrupole field (cusp field) around the material. The material used for generating the DC quadrupole field must be nonconducting to avoid eddy-current heating and of low magnetic permeability to avoid distorting the induction fields providing the levitation.
Abstract translation: 一种用于阻尼在电磁悬浮材料中引起的振荡和旋转运动的系统。 两个相对的磁场磁体与现有的悬浮线圈正交设置，用于在材料周围提供一个直流四极场（尖点场）。 用于产生直流四极场的材料必须是不导电的，以避免涡流加热和低磁导率，以避免扭曲提供悬浮的感应场。
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公开(公告)号：US08535910B2
公开(公告)日：2013-09-17
申请号：US13349514
申请日：2012-01-12
Applicant: S. Christopher Davis , Richard J. Fox , Vesna Mitchell , Gjalt W. Huisman , Lisa M. Newman
Inventor： S. Christopher Davis , Richard J. Fox , Vesna Mitchell , Gjalt W. Huisman , Lisa M. Newman
Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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公开(公告)号：US20100248312A1
公开(公告)日：2010-09-30
申请号：US11581946
申请日：2006-10-16
Applicant: Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Inventor： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
Abstract translation: 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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公开(公告)号：US20090312196A1
公开(公告)日：2009-12-17
申请号：US12483089
申请日：2009-06-11
Applicant: Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox
Inventor： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox
CPC classification number: C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
Abstract: The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
Abstract translation: 本公开涉及生成包含相对于参照多核苷酸的确定的核苷酸差异的多核苷酸变体文库的方法。
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公开(公告)号：US20080298042A1
公开(公告)日：2008-12-04
申请号：US11809210
申请日：2007-05-30
Applicant: Richard J. Fox, IV
Inventor： Richard J. Fox, IV
IPC: H02B1/01
CPC classification number: H04Q1/06 , H04Q1/09 , H05K9/0062
Abstract: A system and method are disclosed for providing an improved rack arm system wherein insulating material is utilized to guard against stray voltage. The system and method entail providing insulated rack arm systems for installation in new locations as well as a snap-on insulating piece for utilization with existing rack arm systems.
Abstract translation: 公开了一种用于提供改进的齿条臂系统的系统和方法，其中使用绝缘材料来防止杂散电压。 该系统和方法需要提供用于安装在新位置的绝缘齿条臂系统以及用于与现有机架臂系统一起使用的卡扣式绝缘件。
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