公开(公告)号：US10544096B2

公开(公告)日：2020-01-28

申请号：US16316539

申请日：2017-07-12

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Sivakumar Sreeramagiri ,  Deshmukh Sandesh Shivajirao ,  Samir Anapat ,  Vishal Keshaorao Karmore ,  Sanjay Katrekar ,  Alok Pal

IPC: C07D209/46 ,  C07D209/44 ,  C08G64/30 ,  C08G64/12

Abstract: A continuous method for the manufacture of a 2-aryl-3,3-bis(hydroxyaryl)phthalimidine comprising continuously heating an anhydride with a phenol in the presence of a catalyst and a first co-catalyst, to form a first reaction mixture comprising a phenolphthalein compound; precipitating the phenolphthalein compound; combining a primary arylamine with an acid catalyst and a second co-catalyst to form a second reaction mixture; adding the phenolphthalein compound to the second reaction mixture; continuously heating the second reaction mixture to provide a third reaction mixture comprising a crude phthalimidine; and treating the crude phthalimidine to remove aminophenol and purify the phthalimidine is provided.